Results 161 to 170 of about 549,355 (294)

Multi‐omic analysis of biological aging biomarkers in long‐term calorie restriction and endurance exercise practitioners: A cross‐sectional study

open access: yesAging Cell, Volume 24, Issue 4, April 2025.
We observed lower biomarkers of biological aging in individuals practicing calorie restriction (CR) and endurance exercise runners (EX) compared to sedentary controls following a Western diet (WD), based on multiple omic analyses. These findings support recent epidemiological findings about the beneficial effect of CR and EX, suggest potential tissue ...
Giovanni Fiorito   +11 more
wiley   +1 more source

Reproductive‐Triggered Sterol Competition Exacerbates Age‐Related Intestinal Barrier Damage in Drosophila Females

open access: yesAging Cell, EarlyView.
Dietary sterols are essential nutrients for maintaining intestinal barrier integrity. Sterol competition caused by female reproduction exacerbates intestinal barrier damage during aging, thereby shortening female lifespan. ABSTRACT The trade‐off between reproduction and lifespan has been documented across a wide array of organisms, ranging from ...
Guixiang Yu   +3 more
wiley   +1 more source

Age‐Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice

open access: yesAging Cell, EarlyView.
The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai   +7 more
wiley   +1 more source

Extensions of Bicomplex Hypergeometric Functions and Riemann–Liouville Fractional Calculus in Bicomplex Numbers

open access: yesFractal and Fractional
In this paper, we present novel advancements in the theory of bicomplex hypergeometric functions and their applications. We extend the hypergeometric function to bicomplex parameters, analyse its convergence region, and define its integral and derivative
Ahmed Bakhet   +4 more
doaj   +1 more source

Pyrroloquinoline Quinone Reprograms the Single‐Cell Landscape of Immune Aging in Hematopoietic Immune System

open access: yesAging Cell, EarlyView.
This study demonstrates that aging induces oxidative stress and inflammation in the hematopoietic immune system, resulting in immune homeostasis dysfunction, including alterations in B cells and hematopoietic stem cells, senescent cells (SnCs) accumulation, and senescence‐associated secretory phenotypes (SASPs) production. Notably, the study highlights
Xiuxing Liu   +11 more
wiley   +1 more source

On bounds involving k-Appell's hypergeometric functions. [PDF]

open access: yesJ Inequal Appl, 2017
Awan MU, Noor MA, Mihai MV, Noor KI.
europepmc   +1 more source

Single‐Cell RNA‐Seq Reveals Aging‐Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury

open access: yesAging Cell, EarlyView.
Microglia engage with apoptotic cells via cell‐surface receptors, such as proto‐oncogene tyrosine‐protein kinase MER (MerTK) and Axl; these receptors interact with the bridging molecule growth arrest‐specific 6 (Gas6) on apoptotic cells. Young microglia demonstrate efficient efferocytosis of apoptotic cells, but this process is impaired in aged ...
Pan Liu   +10 more
wiley   +1 more source

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