Results 101 to 110 of about 38,611 (276)

From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

open access: yesAdvanced Science, EarlyView.
ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao   +14 more
wiley   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen   +17 more
wiley   +1 more source

Hybrid Algorithm via Reciprocal-Argument Transformation for Efficient Gauss Hypergeometric Evaluation in Wireless Networks

open access: yesMathematics
The rapid densification of wireless networks demands efficient evaluation of special functions underpinning system-level performance metrics.
Jianping Cai, Zuobin Ying
doaj   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

open access: yesAdvanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta   +4 more
wiley   +1 more source

Comments on the multi-spin solution to the Yang-Baxter equation and basic hypergeometric sum/integral identity

open access: yes, 2017
We present a multi-spin solution to the Yang-Baxter equation. The solution corresponds to the integrable lattice spin model of statistical mechanics with positive Boltzmann weights and parameterized in terms of the basic hypergeometric functions.
Gahramanov, Ilmar, Jafarzade, Shahriyar
core  

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

open access: yesAdvanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai   +15 more
wiley   +1 more source

An identity for simplifying certain generalized hypergeometric functions [PDF]

open access: yesMathematics of Computation, 1975
In this paper, an identity is proved in which certain generalized hypergeometric functions N P F N Q + N − 1 _{NP}{F_{NQ + N - 1 ...
openaire   +2 more sources

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