Results 101 to 110 of about 1,745,713 (225)

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

open access: yesCytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith   +9 more
wiley   +1 more source

Transcriptome and proteome analyses reveal divergent adaptive strategies in nasopharyngeal epithelial cells and nasopharyngeal carcinoma cells under ultra‐low background radiation

open access: yesDeep Underground Science and Engineering, EarlyView.
This study demonstrates that the ultra‐low background radiation environment in deep underground laboratories significantly inhibits the proliferation of both normal nasopharyngeal epithelial cells (HNEPC) and nasopharyngeal carcinoma cells (HNE‐1) cells, with malignant cells exhibiting higher sensitivity.
Yuhao Zou   +15 more
wiley   +1 more source

Human pressure, habitat heterogeneity and species traits jointly determine the level of dark diversity in coastal fish communities

open access: yesEcography, EarlyView.
Understanding how anthropogenic pressures and environmental gradients shape coastal fish communities is a central question in biogeography and marine conservation. Yet, the set of species expected to occur at a site given ecological conditions but being absent – the so‐called dark diversity – has received far less attention than observed species, even ...
Loïc Sanchez   +23 more
wiley   +1 more source

New hypergeometric transformations

open access: yes, 1998
The elementary manipulation of series is applied to obtain a quite general transformation involving hypergeometric functions. Hypergeometric identities not previously recorded in the literature are then deduced by means of Gauss's summation theorem and ...
Exton, H.
core   +1 more source

Shared molecular pathways in pediatric genetic epilepsies: Insights from a single‐center cohort of 80 patients

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Genetic epilepsies in childhood are highly heterogeneous, and approaches to identify shared biological mechanisms across distinct genetic etiologies remain limited. We aimed to investigate whether genes associated with pediatric genetic epilepsies in our heterogeneous cohort converge on common functional pathways.
Laura Hecher   +11 more
wiley   +1 more source

Legendre inversions and Ultra-hypergeometric series identities [PDF]

open access: yes, 2019
In this paper, we extension of hypergeometric series to obtain a new α-hypergeometric series, we establish three terminating Ultra-hypergeometric series identities, by means of Legendre inverse series relations.
., Wuyungaowa, ., Basen
core   +2 more sources

System‐Local Axes and Metabolic Reprogramming From Health to Response in House Dust Mite‐Specific Subcutaneous Immunotherapy for Allergic Rhinitis

open access: yesiMetaMed, EarlyView.
This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang   +13 more
wiley   +1 more source

A Cross‐Species Hormone Knowledge Base With Multi‐Dimensional Data Integration and Intelligent Query Assistance

open access: yesiMetaMed, EarlyView.
AHormoneDB is a no‐code platform that combines DOID‐standardized hormone–disease associations, regulatory prediction, and retrieval‐augmented generation‐based querying. In acromegaly, it nominated PTPN1 as a previously underappreciated candidate, demonstrating its capacity to accelerate mechanistic discovery.
Xingxing Huang   +6 more
wiley   +1 more source

A multi-dimensional extension of Sylvester’s identity

open access: yes, 2017
We obtain by combinatorial means, a multi-dimensional extension of Sylvester’s famous identity of 1882 that generalized Euler’s Pentagonal Numbers Theorem. We also provide a purely [Formula: see text]-hypergeometric proof.
Krishnaswami Alladi
core   +1 more source

Butyrate ameliorates acute‐on‐chronic liver failure by regulating macrophage polarization

open access: yesiMetaOmics, EarlyView.
Multi‐omics profiling identifies progressive microbiota‐metabolism‐immunity axis dysfunction in acute‐on‐chronic liver failure (ACLF), characterized by gut dysbiosis, reduced butyrate production, intestinal barrier disruption, microbial translocation, and pro‐inflammatory macrophage polarization, thereby exacerbating hepatic inflammation and fibrosis ...
Jing Xiao   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy