Results 171 to 180 of about 9,846 (249)

Superenhancers shape the landscape and repair dynamics of transcription-associated DNA breaks in cancer. [PDF]

Sci Adv
Hidmi O, Shatleh D, Flayshman SO, Monin J, Aqeilan RI.   +4 more
europepmc   +1 more source

Salvianolic Acid B Alleviates MAFLD by Targeting PPAR‐α: Mechanistic Insights From Network Pharmacology and Lipidomics

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Salvianolic acid B (SALB) is the major water‐soluble bioactive constituent of Salvia miltiorrhiza Bunge, a traditional Asian health‐promoting food, while its therapeutic potential and molecular mechanisms in the pathogenesis of MAFLD remain largely unclear.
Fengyan Huang, Chen Qiu, Danna Wang, Yuanying Ni, Zhuotao Fu, Linchun Fu, Chao Liang, Shangyi Huang, Zhitong Deng   +8 more
wiley   +1 more source

Trans‐Omics Integration Reveals That the Kidney Contributes to Systemic Aging via Sexually Dimorphic Accumulation of Glycosphingolipids

MedComm, Volume 7, Issue 3, March 2026.
Female‐specific renal GluCer accumulation disrupts mitochondrial quality control via a conserved purine‐mTORC1 pathway, triggering a wave of uremic toxins into the systemic circulation that constitutes a female‐biased vulnerability toward renal‐driven multiorgan senescence.
Zhen Ni, Chenyin Cao, Yanlin Tian, Jinming Mu, He Tian, Zehua Wang, Shaohua Zhang, Mingjun Cao, Yuntian Yang, Wei Ling Florence Lim, Jingkang Cui, Huan Sun, Huan Miao, Yuan Wang, Jie Du, Timothy Kwok, Huan Chen, Sin Man Lam, Guanghou Shui   +18 more
wiley   +1 more source

Highly Recurrent Multinucleotide Mutations in SARS-CoV-2. [PDF]

Mol Biol Evol
De Maio N, Anoufa O, Smith K, Turakhia Y, Goldman N.   +4 more
europepmc   +1 more source

Truncated FOS impairs osteogenic differentiation and induces prostaglandin and NFκB signalling in an in vitro cell‐of‐origin model for osteoid osteoma and osteoblastoma

The Journal of Pathology, Volume 268, Issue 3, Page 263-275, March 2026.
Abstract Osteoid osteoma and osteoblastoma are non‐malignant bone‐forming tumours of the skeleton, characterised by the presence of irregular trabeculae of woven bone. Rearrangements in FOS, and less frequently FOSB, have recently been identified in osteoid osteoma and osteoblastoma.
Suk Wai Lam, Tatiana Belova, Natasja Franceschini, Brendy van den Akker, David GP van IJzendoorn, Harald MM Mikkers, Hailiang Mei, Anne‐Marie Cleton‐Jansen, Marieke L Kuijjer, Karoly Szuhai, Judith VMG Bovée   +10 more
wiley   +1 more source

WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity. [PDF]

Nat Commun
Wang D, Shi X, Xie J, Zhao L, Wu B, Dong Q, Huang Y, Suo J, Wang X, He B, Yan S, Xue H, Shi Y, Liu Y, Wang J, Chen Y, Li Y.   +16 more
europepmc   +1 more source

A comprehensive review of cluster methods for drug–drug interaction network

Quantitative Biology, Volume 14, Issue 1, March 2026.
Abstract The detection of drug–drug interaction (DDI) is crucial to the rational use of drug combinations. Experimentally, DDI detection is time‐consuming and laborious. Currently, researchers have developed a variety of computational methods to predict DDI.
Shuyuan Cao, Guixia Liu, Xiangrun Zhou, Ji Lv   +3 more
wiley   +1 more source

Spatial joint profiling of DNA methylome and transcriptome in tissues. [PDF]

Nature
Lee CN, Fu H, Cardilla A, Zhou W, Deng Y.   +4 more
europepmc   +1 more source

The mirage of DNA methylation in transcriptional regulation of plants

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract “Cytosine methylation plays an important role in the regulation of gene expression in plants.” Some iteration of this statement can be found in most papers centered on plant epigenetics and has become a widely accepted textbook claim. However, our generalized understanding of how DNA methylation exerts control over transcription is now ...
Peter Civan, Iris Sammarco, Meriem Banouh   +2 more
wiley   +1 more source