Results 151 to 160 of about 1,745,713 (225)

A Three Amino Acid Sequence Gates Protein Stability Control of bHLH104 and Iron Uptake in Arabidopsis thaliana

open access: yesPlant, Cell &Environment, Volume 49, Issue 12, Page 10421-10441, December 2026.
ABSTRACT Iron (Fe) homeostasis is regulated to prevent iron imbalance, with the help of redundant basic helix‐loop‐helix (bHLH) IVc transcription factors that can be controlled by Fe‐binding E3 ligases such as BRUTUS (BTS) in Arabidopsis thaliana.
Dibin Baby   +5 more
wiley   +1 more source

c‐MET Inhibition Is Accompanied by PD‐L1 Upregulation and Immunosuppression‐Related Tumor Microenvironment Changes in Esophageal Squamous Cell Carcinoma, With Enhanced Antitumor Activity in Combination With Anti‐PD‐1 Therapy

open access: yesCancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background c‐MET is implicated in ESCC progression, but whether c‐MET inhibition reshapes immune checkpoint expression and the tumor immune microenvironment remains unclear. Methods ESCC cell lines were treated with Tepotinib, and c‐MET and PD‐L1 expression were examined by Western blotting and immunofluorescence.
Chuan Song   +7 more
wiley   +1 more source

Plasma Lipidomic Features of Adolescent Major Depressive Disorder and Lipid Changes After Fluoxetine Treatment

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Dysregulated plasma lipid homeostasis with aberrant triglycerides, lysophospholipids, and membrane sphingolipids represents a core pathological feature of adolescent major depressive disorder. Eight‐week fluoxetine treatment remodels lipid profiles including bile acid metabolites and modulates key signaling pathways, supporting novel lipid‐based ...
Chenxi Liu   +16 more
wiley   +1 more source

A Multi‐Tissue Transcriptomic Resource for the Brahminy Blindsnake Indotyphlops braminus (Squamata: Typhlopidae)

open access: yesEcology and Evolution, Volume 16, Issue 11, November 2026.
We analyzed multi‐tissue expression patterns in the all‐female, parthenogenetic, and triploid Brahminy blindsnake (Indotyphlops braminus) using PacBio and Illumina RNA‐seq to better understand polyploidy and asexual reproduction in vertebrates. By characterizing differential expression and co‐expression networks across the ovary, heart, liver, skin ...
Kexin Sun   +5 more
wiley   +1 more source

Explicit minimisers for anisotropic Riesz energies. [PDF]

open access: yesCalc Var Partial Differ Equ
Frank RL   +5 more
europepmc   +1 more source

Molecular Adaptations and Sex‐Biased Regulatory Pathways in Multi‐Year Diapause of the Cabbage Beetle Colaphellus bowringi: A Duration‐Resolved Transcriptomic Analysis

open access: yesEcology and Evolution, Volume 16, Issue 11, November 2026.
This study presents the first multi‐duration, sex‐stratified transcriptomic analysis of prolonged diapause in Colaphellus bowringi, revealing that extended dormancy is maintained by coordinated metabolic suppression and sustained activation of cytoprotective pathways (e.g., glutathione metabolism, autophagy).
Lili Huang   +5 more
wiley   +1 more source

Salicylic Acid as a Food‐Derived Bioactive Constituent of Tiaoqi Daozhi Decoction: A Potential Functional Food Ingredient to Restoring Gut Barrier Function in Constipation‐Predominant IBS

open access: yesFood Science &Nutrition, Volume 14, Issue 11, November 2026.
Tiaoqi Daozhi Decoction (TQDZD) is a classic formulation composed of eight medicine‐food homologous botanicals. UPLC‐MS/MS profiling identified 1962 non‐redundant compounds in its aqueous extract, predominantly phenolic acids and flavonoids, of which 107 metabolites were systemically bioavailable.
Min Duan   +4 more
wiley   +1 more source

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