Results 181 to 190 of about 283,047 (289)

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Hyperglycemia-Induced Loss of Astrocytic Kir4.1 Is Associated with Increased DNMT1 Activity and Altered AMPK/SIRT1 Signaling. [PDF]

Cells
Colón-Vázquez J, Hernández-Santiago Y, Malpica-Nieves CJ, Rosado-Rivera NM, Navedo-Jackson JJ, Angueira-Laureano AA, Méndez-González MP, Kucheryavykh Y, Eaton MJ, Skatchkov SN, Rivera-Aponte DE.   +10 more
europepmc   +1 more source

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source

Hyperglycemia 72 h before necrotizing enterocolitis onset and mortality among premature and term infants in Kenya. [PDF]

PeerJ
Muhia M, Ochieng R, Migowa A.
europepmc   +1 more source

Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis

iNew Medicine, EarlyView.
This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang, Rongyu Guo, Xiaojun Feng, Liqin Tang   +3 more
wiley   +1 more source

Hepatocyte‐Centered Regulation of MASH Fibrosis: From Animal Models to Molecular Mechanisms and Targeted Therapies

iNew Medicine, EarlyView.
This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley   +1 more source

Putative Novel miR-1133 Is Associated with Oxidative Stress in Hyperglycemia-Induced Endothelial Cells. [PDF]

Biomedicines
Othman NS, Aminuddin A, Hamid AA, Abidin SZ, Syafruddin SE, Ahmad MF, Jaffar FHF, Othman Basri NA, Ugusman A.   +8 more
europepmc   +1 more source

Protective Effects of Imeglimin Against Oxaliplatin‐Induced Peripheral Neurotoxicity: Evidence From In Vitro and In Vivo Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Oxaliplatin is a platinum‐based anticancer agent widely used for gastrointestinal malignancies; however, it is known to cause dose‐dependent peripheral neuropathy (OIPN), a characteristic adverse effect. OIPN results in a reduced quality of life and often necessitates dose reduction or discontinuation of oxaliplatin; however, effective ...
Yusuke Koura, Kano Kinjo, Keisuke Mine, Yusuke Mori, Mami Ueda, Risa Kaneko, Yuna Kamiya, Taiga Sonoda, Haruka Mimata, Shunsuke Fujita, Takehiro Kawashiri, Daisuke Kobayashi   +11 more
wiley   +1 more source

Epigallocatechin-3-gallate Modulates Hyperglycemia-Triggered Macrophage Autophagy Through miR-204-5p Suppression: Implication for Acute Cardiometabloic Injury. [PDF]

J Acute Med
Lin CM, Wang BW, Fang WJ, Pan CM, Shyu KG.   +4 more
europepmc   +1 more source

Liver Proteomic Alterations Induced by Chronic Fluoride Exposure in Type 2 Diabetic Mice: An Exploratory Study

Journal of Applied Toxicology, EarlyView.
ABSTRACT Water fluoridation is recognized as one of the major public health achievements of the 20th century due to its effectiveness in reducing dental caries. Recommended fluoride concentrations in drinking water (0.7–1.5 mgF/L) aim to maximize dental benefits while minimizing adverse effects.
Laura Ribeiro, Heloisa Aparecida Barbosa da Silva Pereira, Juliana Sanches Trevizol, Aislan Quintiliano Delgado, Aline Dionízio, Tamara Teodoro Araujo, Tânia Mary Cestari, José Roberto Bosqueiro, Marília Afonso Rabelo Buzalaf   +8 more
wiley   +1 more source