Results 231 to 240 of about 367,425 (291)

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

open access: yesInterdisciplinary Medicine, EarlyView.
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen   +5 more
wiley   +1 more source

Endothelial derived microvesicles modulate cerebrovascular and brain aging via MiR‐17‐5p and the biomarker potential in vascular aging

open access: yesInterdisciplinary Medicine, EarlyView.
Y.EMVs released from young endothelial cells (ECs) prevented vascular aging by ameliorating ECs senescence and dysfunction via regulating miR‐17‐5p, and subsequently inhibited brain aging. O.EMVs released from the senescent ECs played the opposite roles, accompanied with a significant increase of EMVs level and downregulation of miR‐17‐5p encapsulated ...
Huiting Zhang   +9 more
wiley   +1 more source

Light‐Mediated Insulin and Amylin Secretion: Influence of Irradiation Parameters in Optogenetically Modified Mouse‐Pancreatic β Cells

open access: yesJournal of Biophotonics, EarlyView.
This study demonstrates variation in photo‐induced secretion of insulin and amylin from Channelrhodopsin‐2 expressing MIN6 cells under different irradiation conditions. For the first time, an alteration in the relative ratio of amylin: insulin is observed with varying irradiation conditions.
Nidhi Maharwal   +3 more
wiley   +1 more source

LLM-Powered Prediction of Hyperglycemia and Discovery of Behavioral Treatment Pathways from Wearables and Diet. [PDF]

open access: yesSensors (Basel)
Mamun A   +6 more
europepmc   +1 more source

Evaluation of the Pharmacokinetics, Disposition, and Metabolism of Miricorilant, a Novel Glucocorticoid Receptor Modulator for the Treatment of Metabolic Dysfunction‐Associated Steatohepatitis in Nonclinical and Clinical Studies

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Miricorilant is a novel selective glucocorticoid receptor (GR) modulator with mixed agonist/antagonist effects at the GR and modest antagonism at the mineralocorticoid receptor that is being developed for the treatment of metabolic dysfunction‐associated steatohepatitis.
Hazel J. Hunt   +3 more
wiley   +1 more source

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