Results 61 to 70 of about 12,908 (219)

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

Role of video-assisted thoracoscopic sympathectomy in the treatment of primary hyperhidrosis

São Paulo Medical Journal
CONTEXT: Essential hyperhidrosis is a frequent disorder causing significant functional impairment. The advent and development of video-assisted thoracoscopic techniques now allows thoracic sympathectomy to be carried out precisely and safety with good ...
Luiz Eduardo Villaça Leão, Renato de Oliveira, Renuzza Szulc, Jair de Jesus Mari, Pedro Luis Reis Crotti, José Julio Saraiva Gonçalves   +5 more
doaj   +1 more source

Safety and Efficacy Findings From a Phase Ib/II Study of ASP‐1929 Photoimmunotherapy With Pembrolizumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma

Head &Neck, Volume 48, Issue 1, Page 160-174, January 2026.
ABSTRACT Background ASP‐1929 photoimmunotherapy—cetuximab conjugated to IRDye 700DX and red light (690 nm) for localized drug activation—results in rapid, selective cell killing. Methods This phase Ib/II open‐label study evaluated ASP‐1929 photoimmunotherapy plus pembrolizumab in patients with recurrent/metastatic HNSCC (≥ 1 accessible lesion, PD‐L1 ...
David M. Cognetti, Joseph M. Curry, Jennifer Johnson, Michael Kwon, Shirley Y. Su, Francisco Civantos, Coral Olazagasti, Joseph Valentino, Susanne M. Arnold, R. Bryan Bell, Michael K. Gibson, Kyle Mannion, Kathryn M. Van Abel, Katharine A. Price, Haiying Dong, Amy H. Thorne, Toshiaki Suzuki, Ann M. Gillenwater   +17 more
wiley   +1 more source

Decreased work productivity due to primary palmar hyperhidrosis. What is the cost?

Skin Health and Disease, 2021
J. K. Kristensen, C. Nielsen
doaj   +1 more source

Is gender a predictive factor for satisfaction among patients undergoing sympathectomy to treat palmar hyperhidrosis?

Clinics, 2010
Video-assisted thoracic sympathectomy (VATS) is currently the procedure of choise for the definitive treatment of primary hyperhidrosis because it is an effective, safe, and minimally invasive method.
Nelson Wolosker, Marco Antonio Soares Munia, Paulo Kauffman, José Ribas Milanez de Campos, Guilherme Yazbek, Pedro Puech-Leão   +5 more
doaj   +1 more source

Genetic and Environmental Associations Among Pain, Sleep Disturbances, and Substance Use Intent in Early Adolescence

Journal of Adolescence, Volume 98, Issue 1, Page 228-236, January 2026.
ABSTRACT Purpose Pain, sleep disturbances, and substance use are common in adolescence, with research indicating that genetic and environmental factors account for variation in each of these behavioral and health outcomes. Moreover, pain, sleep disturbances, and substance use often co‐occur during adolescence. However, research has not examined whether
Kit K. Elam, Angel Trevino, Jodi Kutzner, Jinni Su, Patrick D. Quinn   +4 more
wiley   +1 more source

Topical anticholinergic medications for primary hyperhidrosis: A protocol for systematic review and meta-analysis [PDF]

, 2022
Dongyang Gao, yuanyuan shi
openalex   +1 more source

Efficacy and safety of zuranolone in Japanese adults with major depressive disorder: A double‐blind, randomized, placebo‐controlled, Phase 3 clinical trial

Psychiatry and Clinical Neurosciences, Volume 80, Issue 1, Page 76-86, January 2026.
Aim To evaluate the efficacy and safety of oral zuranolone for 14 days, compared with placebo, in Japanese patients with major depressive disorder (MDD). Methods This multicenter, Phase 3 study was conducted in two parts (70 sites; Japan) including a randomized, double‐blind, placebo‐controlled, parallel‐group part presented herein.
Masaki Kato, Kazuyuki Nakagome, Takamichi Baba, Takuhiro Sonoyama, Hiroki Fukuju, Ryosuke Shimizu, Juan Carlos Gomez, Tomoko Motomiya, Takeshi Inoue   +8 more
wiley   +1 more source

Botulinum Toxin A and B for Palmoplantar Hyperhidrosis

Dermatology and Therapy
Introduction Hyperhidrosis is characterized by unpredictable, uncontrollable and excessive sweating. It occurs at rest and is not related to temperature. Hyperhidrosis is a common disorder that has a negative impact on quality of life (QoL).
Trond Eilertsen, Bjørn Øivind Kvammen, Øystein Grimstad   +2 more
doaj   +1 more source

A Pilot Study, to Evaluate the Safety and Efficacy of Topically Applied Onabotulinum Toxin A Delivered through a Novel Iontophoresis Device in Subjects with Axillary Hyperhidrosis

, 2022
Mark S. Nestor, Haowei Han, Anita Gade, Francesca Ceci, Alec Lawson, Austin Dunn, Faraz Yousefian, Ciaran Smythe   +7 more
openalex   +2 more sources