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The antidepressant mechanism of Hypericum perforatum
Life Sciences, 2004Clinical data indicate that hydroalcoholic extracts of Hypericum perforatum might be as valuable as conventional antidepressants in mild-to-moderate depression, with fewer side effects. One clinical trial using two extracts with different hyperforin contents indicated it as the main active principle responsible for the antidepressant activity ...
Tiziana, Mennini, Marco, Gobbi
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Flavour and Fragrance Journal, 2006 The composition of the essential oils of the Hypericum perforatum L., Hypericum tetrapterum Fries and Hypericum olympicum L. is reported. GC-MS analyses showed α-pinene (21.0%) and 2-methyl-octane (12.6%) as the most abundant components of H. perforatum,
Pavlović, M. +3 more
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Final Report on the Safety Assessment of Hypericum Perforatum Extract and Hypericum Perforatum Oil
International Journal of Toxicology, 2001Hypericum Perforatum Extract is an extract of the capsules, flowers, leaves, and stem heads of Hypericum perforatum, commonly called St. John's Wort. Hypericum Perforatum Oil is the fixed oil from H. perforatum. Techniques for preparing Hypericum Perforatum Extract include crushing in stabilized olive oil, gentle maceration over a period of weeks ...
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Phenolic Compounds from Hypericum perforatum
Planta Medica, 2002During a re-investigation of phenolic compounds from the dried crude drug material of St. John's wort (Hypericum perforatum L.) 22 phenolic compounds were detected by HPLC; 14 of them were quantified using the same system. Twelve phenolic compounds were isolated from the plant material and their structures identified mainly by spectroscopic methods ...
Guido, Jürgenliemk, Adolf, Nahrstedt
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Xanthones from calli ofHypericum Perforatumsubsp.Perforatum
Natural Product Research, 2005Two new xanthone derivatives, 1-hydroxy-5,6,7-trimethoxyxanthone and 3-O-methylpaxanthone were isolated from callus of Hypericum perforatum subsp. perforatum together with the known paxanthone, cadensin G, 1-hydroxy-6,7-dimethoxyxanthone, 1,3,6,7-tetrahydroxyxanthone, and 1,3,5,6-tetrahydroxyxanthone.
Franco Ferrari +4 more
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Induction of imatinib metabolism by hypericum perforatum
Blood, 2004Hypericum perforatum (St John Wort) is an herbal preparation commonly used by cancer patients for mood elevation and is known to induce intestinal and hepatic cytochrome P450 3A4 (CYP3A4) and P-glycoprotein.[1][1] CYP3A4 is the major isoenzyme responsible for imatinib metabolism, making ...
Patrick F, Smith +5 more
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Hypericum perforatum - a Review of Clinical Studies
Pharmacopsychiatry, 2001St. John's wort (Hypericum perforatum) has been used as a medicinal herb for over 2000 years. Over the past 2 decades, its application as a plant extract for treating depression has undergone rigorous scientific investigation, and its effectiveness has been shown in studies comparing it with placebo and preference antidepressants.
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Hypericum perforatum, a Source of Neuroactive Lead Structures
Current Topics in Medicinal Chemistry, 2003Although St. John's wort has been known for thousands of years and has been used for a variety of medicinal purposes, understanding of its activity and mechanisms of action is relatively new and not well understood. While researchers originally thought the naphthodianthrone hypericin was responsible for Hypericum's antidepressant activity, it is now ...
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