Hypericin enhances β-lactam antibiotics activity by inhibiting sarA expression in methicillin-resistant Staphylococcus aureus [PDF]
Acta Pharmaceutica Sinica B, 2019 Bacteremia is a life-threating syndrome often caused by methicillin-resistant Staphylococcus aureus (MRSA). Thus, there is an urgent need to develop novel approaches to successfully treat this infection.
Genzhu Wang +8 more
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Hypericin Inhibit Alpha-Coronavirus Replication by Targeting 3CL Protease
Viruses, 2021 The porcine epidemic diarrhea virus (PEDV) is an Alphacoronavirus (α-CoV) that causes high mortality in infected piglets, resulting in serious economic losses in the farming industry. Hypericin is a dianthrone compound that has been shown as an antiviral
Yue Zhang, Huijie Chen, Ruili Zhang
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Hypericin alleviates cerebral ischemia/reperfusion injury by modulating endoplasmic reticulum stress [PDF]
Frontiers in PharmacologyIntroductionCerebral ischemia/reperfusion (I/R) injury remains a leading cause of neurological disability and is characterized by oxidative stress, calcium overload, inflammation, and endoplasmic reticulum (ER) stress following reperfusion.
Tingting Li, Chao Wang
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Hypericin in the Light and in the Dark: Two Sides of the Same Coin
Frontiers in Plant Science, 2016 Hypericin (4,5,7,4',5',7'-hexahydroxy-2,2'-dimethylnaphtodiantrone) is a naturally occurring chromophore found in plants of the genus Hypericum, especially Hypericum perforatum L. (St.
Rastislav Jendželovský +1 more
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Inhibition of dengue virus type 2 by hypericin mediated through viral envelope protein interaction [PDF]
Virology JournalBackground Dengue fever continues to exert significant global impact, affecting populations worldwide with considerable public health and economic consequences. There is no antiviral drug for dengue. This study focuses on hypericin, a naturally occurring
Lianxin Qi +6 more
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Detection of a Water-Soluble Hypericin Formulation in Glioblastoma Tissue with Fluorescence Lifetime and Intensity Using a Dual-Tap CMOS Camera System [PDF]
DiagnosticsBackground: High hypericin-loaded polyvinylpyrrolidone (HHL-PVP) constitutes a novel approach to utilize the promising characteristics of hypericin for photodynamic diagnosis (PDD) and therapy (PDT) of brain tumors in an orally bioavailable formulation ...
Mario Mischkulnig +15 more
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Foliar application of yeast extract mitigates water deficit stress and elicits hypericin and phenolic production in Hypericum perforatum L [PDF]
Scientific ReportsYeast extract has emerged as a bio-elicitor capable of modulating secondary metabolism and stress tolerance in plants, but its impact on St John’s Wort (Hypericum perforatum L.) remains unexplored.
Rayhaneh Amooaghaie, Nafiseh Rajaie
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Inhibition Effect and Molecular Mechanism of Hypericin on Xanthine Oxidase
Shipin gongye ke-ji, 2022 Dietary flavonoid has been reported to possess a high potential for inhibition xanthine oxidase (XOD). Herein, hypericin was investigated for its inhibition effect and interaction mechanism on XOD by enzyme inhibition kinetics, multi-spectroscopy and ...
Min WANG +4 more
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St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death. [PDF]
PLoS ONE, 2014 Hypericin, an extract from St John's Wort (Hypericum perforatum L.), is a promising photosensitizer in the context of clinical photodynamic therapy due to its excellent photosensitizing properties and tumoritropic characteristics.
Britta Kleemann +4 more
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Inhibitory Activity and Mechanism Investigation of Hypericin as a Novel α-Glucosidase Inhibitor
Molecules, 2021 α-glucosidase is a major enzyme that is involved in starch digestion and type 2 diabetes mellitus. In this study, the inhibition of hypericin by α-glucosidase and its mechanism were firstly investigated using enzyme kinetics analysis, real-time ...
Qi Dong, Na Hu, Huilan Yue, Honglun Wang
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