Results 1 to 10 of about 5,778 (206)

Hypericin Inhibit Alpha-Coronavirus Replication by Targeting 3CL Protease [PDF]

Viruses, 2021
The porcine epidemic diarrhea virus (PEDV) is an Alphacoronavirus (α-CoV) that causes high mortality in infected piglets, resulting in serious economic losses in the farming industry. Hypericin is a dianthrone compound that has been shown as an antiviral
Yue Zhang, Ruili Zhang, Guangxing Li
exaly   +5 more sources

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response. [PDF]

Cancer Sci
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Ma S, Xu Q, Zhu M, Ge X, Xu J, Pan Y, Wang M, Zhu Y, Xu A, Liu H, Xiang G, Gong W, Zhao B.   +12 more
europepmc   +2 more sources

Hypericin alleviates cerebral ischemia/reperfusion injury by modulating endoplasmic reticulum stress. [PDF]

Front Pharmacol
IntroductionCerebral ischemia/reperfusion (I/R) injury remains a leading cause of neurological disability and is characterized by oxidative stress, calcium overload, inflammation, and endoplasmic reticulum (ER) stress following reperfusion.
Li T, Wang C.
europepmc   +2 more sources

Natural Photosensitizers in Cancer Therapy: A Chemo-Biodiversity Perspective on Light-Activated Natural Compounds. [PDF]

Chem Biodivers
Natural photosensitizers, shaped by chemo‐biodiversity and evolution, offer diverse photoactive scaffolds for PDT. This review highlights their structure–activity relationships, photophysical properties, and nanotechnology‐based strategies to enhance efficacy, while addressing translational challenges and demonstrating how nature's molecular diversity ...
Baidoo I, Abrahamse H, George BP.
europepmc   +2 more sources

Hypericin-Mediated Antimicrobial Photodynamic Therapy in Dentistry: A Systematic Review of Applications Against Oral Biofilms and Infections. [PDF]

Pharmaceutics
Background: Oral biofilms are a major etiological factor in dental caries, periodontal disease, peri-implantitis, and endodontic infections. Increasing antimicrobial resistance and the limitations of conventional therapies have intensified interest in ...
Turski R, Dobrzyński M, Warakomska A, Pietrzko M, Gregorczyk-Maga I, Skaba D, Wiench R.   +6 more
europepmc   +2 more sources

Analysis of the Uptake of Hypericin by <i>Candida albicans</i> Yeast Cells Using Fluorescence Methods and Comparison of the Dynamics of This Process over Time. [PDF]

Pharmaceutics
Background: Hypericin is a natural photosensitizer with promising antifungal potential, but its uptake kinetics in Candida (C.) albicans are not well defined. Objective: To characterize the time-dependent uptake of hypericin by C. albicans in vitro using
Turski R, Fiegler-Rudol J, Hüpsch-Marzec H, Skaba D, Wiench R.   +4 more
europepmc   +2 more sources

Inhibition of dengue virus type 2 by hypericin mediated through viral envelope protein interaction. [PDF]

Virol J
Background Dengue fever continues to exert significant global impact, affecting populations worldwide with considerable public health and economic consequences. There is no antiviral drug for dengue. This study focuses on hypericin, a naturally occurring
Qi L, Tang M, Liu L, Cheng J, Xiao Q, Qiu J, Wu J.   +6 more
europepmc   +2 more sources

Foliar application of yeast extract mitigates water deficit stress and elicits hypericin and phenolic production in Hypericum perforatum L. [PDF]

Sci Rep
Yeast extract has emerged as a bio-elicitor capable of modulating secondary metabolism and stress tolerance in plants, but its impact on St John’s Wort (Hypericum perforatum L.) remains unexplored.
Amooaghaie R, Rajaie N.
europepmc   +2 more sources

Inhibition Effect and Molecular Mechanism of Hypericin on Xanthine Oxidase

Shipin gongye ke-ji, 2022
Dietary flavonoid has been reported to possess a high potential for inhibition xanthine oxidase (XOD). Herein, hypericin was investigated for its inhibition effect and interaction mechanism on XOD by enzyme inhibition kinetics, multi-spectroscopy and ...
Min WANG, Guohui XU, Yiling ZHAO, Gangqiang WANG, Ganhui HUANG   +4 more
doaj   +1 more source

St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death. [PDF]

PLoS ONE, 2014
Hypericin, an extract from St John's Wort (Hypericum perforatum L.), is a promising photosensitizer in the context of clinical photodynamic therapy due to its excellent photosensitizing properties and tumoritropic characteristics.
Britta Kleemann, Benjamin Loos, Thomas J Scriba, Dirk Lang, Lester M Davids   +4 more
doaj   +1 more source