Results 1 to 10 of about 345 (114)
Hypericin Inhibit Alpha-Coronavirus Replication by Targeting 3CL Protease
Viruses, 2021 The porcine epidemic diarrhea virus (PEDV) is an Alphacoronavirus (α-CoV) that causes high mortality in infected piglets, resulting in serious economic losses in the farming industry. Hypericin is a dianthrone compound that has been shown as an antiviral
Yue Zhang +9 more
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Inhibition Effect and Molecular Mechanism of Hypericin on Xanthine Oxidase
Shipin gongye ke-ji, 2022 Dietary flavonoid has been reported to possess a high potential for inhibition xanthine oxidase (XOD). Herein, hypericin was investigated for its inhibition effect and interaction mechanism on XOD by enzyme inhibition kinetics, multi-spectroscopy and ...
Min WANG +4 more
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St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death. [PDF]
PLoS ONE, 2014 Hypericin, an extract from St John's Wort (Hypericum perforatum L.), is a promising photosensitizer in the context of clinical photodynamic therapy due to its excellent photosensitizing properties and tumoritropic characteristics.
Britta Kleemann +4 more
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Inhibitory Activity and Mechanism Investigation of Hypericin as a Novel α-Glucosidase Inhibitor
Molecules, 2021 α-glucosidase is a major enzyme that is involved in starch digestion and type 2 diabetes mellitus. In this study, the inhibition of hypericin by α-glucosidase and its mechanism were firstly investigated using enzyme kinetics analysis, real-time ...
Qi Dong, Na Hu, Huilan Yue, Honglun Wang
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Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy. [PDF]
PLoS ONE, 2011 The perihydroxylated perylene quinone hypericin has been reported to possess potent anti-metastatic and antiangiogenic activities, generated by targeting diverse crossroads of cancer-promoting processes via unique mechanisms.
Tilda Barliya +4 more
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Hypericin in the light and in the dark: Two sides of the same coin
Frontiers in Plant Science, 2016 Hypericin (4,5,7,4',5',7'-hexahydroxy-2,2'-dimethylnaphtodiantrone) is a naturally occurring chromophore found in plants of the genus Hypericum, especially Hypericum perforatum L. (St.
Zuzana eJendzelovska +3 more
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Acta Medica, 2001 Cultivation with 4-8 μmol/l hypericin (specific proteinkinase C inhibitor) activated by light induced high inhibition of the rate of HL-60 cell growth.
Martina Mareková +3 more
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Molecules, 2023 Hypericin, one of the major antidepressant constituents of St. John’s wort, was shown to exert antidepressant effects by affecting cerebral CYP enzymes, serotonin homeostasis, and neuroinflammatory signaling pathways.
Chunguang Lei +3 more
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Retrovirology, 2019 Background Adult T-cell leukemia (ATL) is an aggressive neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1). ATL carries a poor prognosis due to chemotherapy resistance. Thus, it is urgent to develop new treatment strategies. Hypericin (HY) is
Lingling Xu +8 more
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Van Tıp Dergisi, 2018 INTRODUCTION: Inflammation is an innate immune response that protects host organism from external injuries and pathogens. The increased inflammatory response in organism can cause many diseases, especially cancer.
Mehmet Berköz +2 more
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