Results 31 to 40 of about 2,331 (162)
Photodiagnosis and Photodynamic TherapyPhotodynamic therapy (PDT) is a minimally invasive therapy for treating cancers, infectious diseases and several other conditions. It uses light as an activator and component called photosensitizer. Hypericin is a natural photosensitizer which garnered a
Monosha Priyadarshini +1 more
doaj +1 more source
Hypericin-Induced Cell Photosensitization Involves an Intracellular pH Decrease
, 2016 Snarf-1-AM (Seminaphthorhodafluor-1-acetoxymethylester) being used as a fluorescent pH probe, confocal laser microspectrofluorometric measurements allowed intracellular pH to be assessed within 3T3 mouse fibroblasts in the presence or in the absence of ...
F. Sureau (2997810) +3 more
core +1 more source
Antimicrobial photodynamic therapy in Candida spp. biofilms: In vitro and in vivo protocols
Photochemistry and Photobiology, EarlyView.This review addresses the critical challenges in translating in vitro antimicrobial photodynamic therapy protocols to in vivo models, with a particular focus on the hurdles of standardization. The vast diversity in photosensitizers and light parameters across different target cells and models requires a rigorous optimization process.
Lívia Mara Alves Figueiredo‐Godoi +2 more
wiley +1 more source
Molecules, 2020 Hypericum perforatum and related species (Hypericaceae) are a reservoir of pharmacologically important secondary metabolites, including the well-known naphthodianthrone hypericin.
Bharadwaj Revuru +4 more
doaj +1 more source
Molecules, 2021 Naphthodianthrones such as fagopyrin and hypericin found mainly in buckwheat (Fagopyrum spp.) and St. John’s wort (SJW) (Hypericum perforatum L.) are natural photosensitizers inside the cell.
Oksana Sytar +11 more
doaj +1 more source
The effect of photodynamic therapy in head and neck cancer: A comprehensive review of in vivo models
Photochemistry and Photobiology, EarlyView.This review evaluates Photodynamic Therapy (PDT) in in vivo head and neck cancer models. PDT effectively generates ROS, reducing tumor growth, cell proliferation and angiogenesis while enhancing survival and immune responses. However, methodological heterogeneity highlights the urgent need for standardized dosimetric protocols to ensure reproducibility
Bibiana Padilha de Menezes da Silva +5 more
wiley +1 more source
Hypericin-Loaded Carbon Nanohorn Hybrid for Combined Photodynamic and Photothermal Therapy in Vivo
, 2019 Photodynamic therapy (PDT) of hypericin (Hyp) is hampered by poor water solubility and photostability. Incorporation of photosensitizers into nanocarriers has been designed to solve these issues.
Cunji Gao (785417) +6 more
core +1 more source
Cancer Science, Volume 117, Issue 9, Page 2567-2585, September 2026.Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma +12 more
wiley +1 more source
DiagnosticsBackground: High hypericin-loaded polyvinylpyrrolidone (HHL-PVP) constitutes a novel approach to utilize the promising characteristics of hypericin for photodynamic diagnosis (PDD) and therapy (PDT) of brain tumors in an orally bioavailable formulation ...
Mario Mischkulnig +15 more
doaj +1 more source
Seasonal Variation of Hypericin and Pseudohypericin Contents in L. Growing Wild in Turkey
Natural Product Communications, 2008 The present study was conducted to determine ontogenetic and morphogenetic variations of hypericin and pseudohypericin contents in Hypericum scabrum growing in Turkey.
Ali Kemal Ayan +2 more
doaj +1 more source