Results 11 to 20 of about 2,331 (162)

Isolation and functional analysis of cDNAs similar to Hyp-1 involved in hypericin biosynthesis from Hypericum erectum

Biologia Plantarum, 2010
Hypericin, a naphthodianthrone, has been identified as the principal active compound found in St. John's wort (Hypericum perforatum L.). To generate a gene resource for hypericin and other valuable metabolites, we generated expressed sequence tags (ESTs)
M. L. Jin, J. C. Ahn, B. Hwang, H. -S. Park, H. S. Lee, D. -W. Choi   +5 more
doaj   +2 more sources

Hypericin enhances superlubricity of glycerol by acting as graphene precursor

Friction
Hypericin (C30H16O8) is a naturally occurring substance, an anthraquinone derived from St. John’s wort, possessing outstanding antiviral, antitumor, antibacterial, and antioxidant properties.
Paul Marie Zubieta-Laborde, Yun Long, Thomas Lubrecht, Graham L. W. Cross, Frédéric Dubreuil, Jean Michel Martin, Maria Isabel De Barros Bouchet   +6 more
doaj   +2 more sources

Hypericin-bearing magnetic iron oxide nanoparticles for selective drug delivery in photodynamic therapy

International Journal of Nanomedicine, 2015
Harald Unterweger,1 Daniel Subatzus,1 Rainer Tietze,1 Christina Janko,1 Marina Poettler,1 Alfons Stiegelschmitt,2 Matthias Schuster,3 Caroline Maake,4 Aldo R Boccaccini,5 Christoph Alexiou11ENT Department, Section of Experimental Oncology and ...
Unterweger H, Subatzus D, Tietze R, Janko C, Poettler M, Stiegelschmitt A, Schuster M, Maake C, Boccaccini AR, Alexiou C   +9 more
doaj   +1 more source

Lipid-Mediated Preferential Localization of Hypericin in Lipid Membranes [PDF]

, 2010
Subcellular localization of a photosensitizer is critical to its therapeutic outcome during photodynamic therapy (PDT). We delineated the distribution of hypericin, a new generation photosensitizer, in model membrane systems to identify the operating ...
何藴芳;吳明煌;陳雅雯;施明智, HO, YUNN-FANG;WU, MING-HUANG;CHEN, YA-WEN;SHIH, MING-CHIH   +1 more
core   +3 more sources

Fluorescence lifetime imaging unravels the pathway of glioma cell death upon hypericin-induced photodynamic therapy [PDF]

, 2023
Malignant primary brain tumors are a group of highly aggressive and often infiltrating tumors that lack adequate therapeutic treatments to achieve long time survival. Complete tumor removal is one precondition to reach this goal.
Marc, Brecht, Tim, Rammler, Rainer, Ritz, Marcus, Scheele, Frank, Wackenhut, Miriam, Bassler, Philipp, Frech, Kai, Braun, Jonas, Hiller, Christoph, Kertzscher, Sven, zur Oven-Krockhaus, Felix, Schmidt, Alfred, J. Meixner   +12 more
core   +2 more sources

Quantitative Proteome Analysis of Leishmania donovani under Spermidine Starvation. [PDF]

PLoS ONE, 2016
We have earlier reported antileishmanial activity of hypericin by spermidine starvation. In the current report, we have used label free proteome quantitation approach to identify differentially modulated proteins after hypericin treatment. A total of 141
Shalini Singh, Vikash Kumar Dubey
doaj   +1 more source

Autophagy and Apoptosis Induced in U87 MG Glioblastoma Cells by Hypericin-Mediated Photodynamic Therapy Can Be Photobiomodulated with 808 nm Light

Biomedicines, 2021
Glioblastoma is one of the most aggressive types of tumors. Although few treatment options are currently available, new modalities are needed to improve prognosis. In this context, photodynamic therapy (PDT) is a promising adjuvant treatment modality. In
Viktoria Pevna, Georges Wagnières, Veronika Huntosova   +2 more
doaj   +1 more source

Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio

Bioscience Reports, 2015
Insulinomas cause neuroglycopenic symptoms, permanent neurological damage and even death. Current available therapies cannot satisfactorily treat malignant insulinomas and some benign insulinomas.
Jingwen Yi, Xiaoguang Yang, Lihua Zheng, Guang Yang, Luguo Sun, Yongli Bao, Yin Wu, Yanxin Huang, Chunlei Yu, Shao‑Nian Yang, Yuxin Li   +10 more
doaj   +1 more source

A Double Payload Complex between Hypericin and All-trans Retinoic Acid in the β-Lactoglobulin Protein

Antibiotics, 2022
Combined therapies are usually used to treat acne vulgaris since this approach can tackle various foci simultaneously. Using a combination of spectroscopic, computational, and microbiological techniques and methods, herein we report on the use of β ...
Beatriz Rodríguez-Amigo, Cormac Hally, Núria Roig-Yanovsky, Pietro Delcanale, Stefania Abbruzzetti, Montserrat Agut, Cristiano Viappiani, Santi Nonell   +7 more
doaj   +1 more source

Evolutionary Aspects of Hypericin Productivity and Endogenous Phytohormone Pools Evidenced in Hypericum Species In Vitro Culture Model

Plants, 2022
Shoot cultures of hypericin non-producing H. calycinum L. (primitive Ascyreia section), hypericin-producing H. perforatum L., H. tetrapterum Fries (section Hypericum) and H. richeri Vill.
Kalina Danova, Vaclav Motyka, Antoaneta Trendafilova, Petre I. Dobrev, Viktorya Ivanova, Ina Aneva   +5 more
doaj   +1 more source