Results 11 to 20 of about 8,749 (218)
A Chemiluminescence-Activated Photodynamic Platform to Penetrate MRSA Biofilms and Counteract H<sub>2</sub>S-Mediated Defense. [PDF]
Small SciA chemiluminescence‐activated photodynamic system is developed to eradicate methicillin‐resistant Staphylococcus aureus (MRSA) biofilms without external light or antibiotics. CO2 generated in situ disrupts biofilms and propels nanocarriers for deep penetration, while hypericin generates reactive oxygen species and suppresses H2S‐mediated defenses. This
Ren W +9 more
europepmc +2 more sources
Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy. [PDF]
PLoS ONE, 2011 The perihydroxylated perylene quinone hypericin has been reported to possess potent anti-metastatic and antiangiogenic activities, generated by targeting diverse crossroads of cancer-promoting processes via unique mechanisms.
Tilda Barliya +4 more
doaj +1 more source
Acute mania and psychosis potentially triggered by St John's wort. [PDF]
PCN RepAbstract Background St John's wort (SJW) is widely used as an herbal supplement for depressive symptoms and is generally regarded as safe. However, although extremely rare, manic and psychotic reactions have been reported, typically in individuals taking high doses, using psychotropic agents, or having a psychiatric history. Case Presentation We report
Yoshioka D, Yamanashi T, Iwata M.
europepmc +2 more sources
Molecules, 2023 Hypericin, one of the major antidepressant constituents of St. John’s wort, was shown to exert antidepressant effects by affecting cerebral CYP enzymes, serotonin homeostasis, and neuroinflammatory signaling pathways.
Chunguang Lei +3 more
doaj +1 more source
Acta Medica, 2001 Cultivation with 4-8 μmol/l hypericin (specific proteinkinase C inhibitor) activated by light induced high inhibition of the rate of HL-60 cell growth.
Martina Mareková +3 more
doaj +1 more source
Effect of photosensitizers photosens, photodithazine and hypericin on glioma cells and primary neuronal cultures : a comparative analysis [PDF]
, 2019 The aim of the study was to compare the effect of photosensitizers photosens, photodithazine, and hypericin on primary brain cell cultures, and assess their toxic effect on tumor and normal nervous cells in order to choose the optimal photodynamic agent ...
Alzeibak, Rozan +6 more
core +2 more sources
Retrovirology, 2019 Background Adult T-cell leukemia (ATL) is an aggressive neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1). ATL carries a poor prognosis due to chemotherapy resistance. Thus, it is urgent to develop new treatment strategies. Hypericin (HY) is
Lingling Xu +8 more
doaj +1 more source
Plants, 2022 Shoot cultures of hypericin non-producing H. calycinum L. (primitive Ascyreia section), hypericin-producing H. perforatum L., H. tetrapterum Fries (section Hypericum) and H. richeri Vill.
Kalina Danova +5 more
doaj +1 more source
DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown [PDF]
, 2011 Damage-associated molecular patterns (DAMPs) or cell death associated molecular patterns (CDAMPs) are a subset of endogenous intracellular molecules that are normally hidden within living cells but become either passively released by primary and ...
Agostinis, Patrizia +3 more
core +1 more source
Quantitative Proteome Analysis of Leishmania donovani under Spermidine Starvation. [PDF]
PLoS ONE, 2016 We have earlier reported antileishmanial activity of hypericin by spermidine starvation. In the current report, we have used label free proteome quantitation approach to identify differentially modulated proteins after hypericin treatment. A total of 141
Shalini Singh, Vikash Kumar Dubey
doaj +1 more source