Results 21 to 30 of about 5,778 (206)

Inhibitory Activity and Mechanism Investigation of Hypericin as a Novel α-Glucosidase Inhibitor

Molecules, 2021
α-glucosidase is a major enzyme that is involved in starch digestion and type 2 diabetes mellitus. In this study, the inhibition of hypericin by α-glucosidase and its mechanism were firstly investigated using enzyme kinetics analysis, real-time ...
Qi Dong, Na Hu, Huilan Yue, Honglun Wang
doaj   +1 more source

Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy. [PDF]

PLoS ONE, 2011
The perihydroxylated perylene quinone hypericin has been reported to possess potent anti-metastatic and antiangiogenic activities, generated by targeting diverse crossroads of cancer-promoting processes via unique mechanisms.
Tilda Barliya, Mathilda Mandel, Tami Livnat, Dov Weinberger, Gad Lavie   +4 more
doaj   +1 more source

Light-Induced Photoactivation of Hypericin Inhibits Cellular Growth in Pituitary Adenoma Cell Line AtT20/D16v-F2 (Hypericin Inhibits Cellular Growth of AtT20/D16v-F2)

Acta Medica, 2001
Cultivation with 4-8 μmol/l hypericin (specific proteinkinase C inhibitor) activated by light induced high inhibition of the rate of HL-60 cell growth.
Martina Mareková, Jiřina Vávrová, Doris Vokurková, Jaroslav Cerman   +3 more
doaj   +1 more source

Hypericin Ameliorates Depression-like Behaviors via Neurotrophin Signaling Pathway Mediating m6A Epitranscriptome Modification

Molecules, 2023
Hypericin, one of the major antidepressant constituents of St. John’s wort, was shown to exert antidepressant effects by affecting cerebral CYP enzymes, serotonin homeostasis, and neuroinflammatory signaling pathways.
Chunguang Lei, Ningning Li, Jianhua Chen, Qingzhong Wang   +3 more
doaj   +1 more source

Hypericin-photodynamic therapy inhibits the growth of adult T-cell leukemia cells through induction of apoptosis and suppression of viral transcription

Retrovirology, 2019
Background Adult T-cell leukemia (ATL) is an aggressive neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1). ATL carries a poor prognosis due to chemotherapy resistance. Thus, it is urgent to develop new treatment strategies. Hypericin (HY) is
Lingling Xu, Xueqing Zhang, Wenzhao Cheng, Yong Wang, Kaining Yi, Zhilong Wang, Yiling Zhang, Linxiang Shao, Tiejun Zhao   +8 more
doaj   +1 more source

Investigation of the effect of hyperforin and hypericin on inflammatory response in RAW 264.7 macrophages

Van Tıp Dergisi, 2018
INTRODUCTION: Inflammation is an innate immune response that protects host organism from external injuries and pathogens. The increased inflammatory response in organism can cause many diseases, especially cancer.
Mehmet Berköz, Oruc Allahverdiyev, Metin Yıldırım   +2 more
doaj   +1 more source

Quantitative Proteome Analysis of Leishmania donovani under Spermidine Starvation. [PDF]

PLoS ONE, 2016
We have earlier reported antileishmanial activity of hypericin by spermidine starvation. In the current report, we have used label free proteome quantitation approach to identify differentially modulated proteins after hypericin treatment. A total of 141
Shalini Singh, Vikash Kumar Dubey
doaj   +1 more source

Autophagy and Apoptosis Induced in U87 MG Glioblastoma Cells by Hypericin-Mediated Photodynamic Therapy Can Be Photobiomodulated with 808 nm Light

Biomedicines, 2021
Glioblastoma is one of the most aggressive types of tumors. Although few treatment options are currently available, new modalities are needed to improve prognosis. In this context, photodynamic therapy (PDT) is a promising adjuvant treatment modality. In
Viktoria Pevna, Georges Wagnières, Veronika Huntosova   +2 more
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Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio

Bioscience Reports, 2015
Insulinomas cause neuroglycopenic symptoms, permanent neurological damage and even death. Current available therapies cannot satisfactorily treat malignant insulinomas and some benign insulinomas.
Jingwen Yi, Xiaoguang Yang, Lihua Zheng, Guang Yang, Luguo Sun, Yongli Bao, Yin Wu, Yanxin Huang, Chunlei Yu, Shao‑Nian Yang, Yuxin Li   +10 more
doaj   +1 more source

A Double Payload Complex between Hypericin and All-trans Retinoic Acid in the β-Lactoglobulin Protein

Antibiotics, 2022
Combined therapies are usually used to treat acne vulgaris since this approach can tackle various foci simultaneously. Using a combination of spectroscopic, computational, and microbiological techniques and methods, herein we report on the use of β ...
Beatriz Rodríguez-Amigo, Cormac Hally, Núria Roig-Yanovsky, Pietro Delcanale, Stefania Abbruzzetti, Montserrat Agut, Cristiano Viappiani, Santi Nonell   +7 more
doaj   +1 more source