Results 41 to 50 of about 2,331 (162)

Natural Photosensitizers in Cancer Therapy: A Chemo‐Biodiversity Perspective on Light‐Activated Natural Compounds

open access: yesChemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Natural photosensitizers, shaped by chemo‐biodiversity and evolution, offer diverse photoactive scaffolds for PDT. This review highlights their structure–activity relationships, photophysical properties, and nanotechnology‐based strategies to enhance efficacy, while addressing translational challenges and demonstrating how nature's molecular diversity ...
Isaac Baidoo   +2 more
wiley   +1 more source

Theoretical and Experimental Evidence of Two‐Step Tautomerization in Hypericin

open access: yesAdvanced Photonics Research, 2021
Hypericin has large potential in modern medicine and exhibits fascinating structural dynamics, such as multiple conformations and tautomerization. However, it is difficult to study individual conformers/tautomers, as they cannot be isolated due to the ...
Quan Liu   +7 more
doaj   +1 more source

The Role of γδ T Cells in Ischemic Stroke: Insights From the Perspective of the Brain–Gut Axis

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
γδ T cells are pivotal in ischemic stroke, directly promoting brain inflammation and indirectly amplifying injury via the brain–gut axis. Through IL‐17 release, they disrupt the intestinal barrier, facilitating a harmful crosstalk that worsens stroke outcomes. Targeting this brain–gut immune axis presents a promising therapeutic strategy.
Yilin Li   +6 more
wiley   +1 more source

Photodynamic therapy – hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity

open access: yesDrug Delivery, 2019
Photodynamic therapy (PDT) is an established noninvasive tumor treatment. The hydrophobic natural occurring pigment hypericin shows a lot of attractive properties for the application in PDT.
Nikola Plenagl   +7 more
doaj   +1 more source

A New UHPLC Analytical Method for St. John’s Wort (Hypericum perforatum) Extracts

open access: yesSeparations, 2023
Commonly used to treat mood disorders, St. John’s Wort (Hypericum perforatum) is a popular herb in the natural health products industry. The potency of its active ingredients can be determined using a number of different analytical methods, but it is ...
Lisa Wang   +3 more
doaj   +1 more source

Hypericin: Source, Determination, Separation, and Properties

open access: yes, 2020
Hypericin is a naturally occurring compound synthesized by certain species of the genus Hypericum, with various pharmacological effects. It is used as a natural photosensitizing agent with great potential in photodynamic therapy.
Zhang, Jie (author)   +13 more
core   +2 more sources

Hypericin- A Napthodianthrone from Hypericum perforatum [PDF]

open access: yes, 2003
Hypericin is a substance isolated from a medicinal herb Hypericum perforatum, commonly known as St.John’s Wort.1 Hypericin belongs to group of compound known as napthodianthrones.
Singh, Amrit Pal
core   +1 more source

Prediction of hypericin content in Hypericum perforatum L. in different ecological habitat using artificial neural networks

open access: yesPlant Methods, 2021
Background Hypericum is an important genus in the family Hypericaceae, which includes 484 species. This genus has been grown in temperate regions and used for treating wounds, eczema and burns.
Maryam Saffariha   +3 more
doaj   +1 more source

In Silico and In Vitro Identification of Pan-Coronaviral Main Protease Inhibitors from a Large Natural Product Library

open access: yesPharmaceuticals, 2022
The main protease (Mpro or 3CLpro) in coronaviruses represents a promising specific drug target as it is essential for the cleavage of the virus polypeptide and has a unique cleavage site that does not exist in human host proteases.
Nasim Shahhamzehei   +2 more
doaj   +1 more source

Multi‐Induction Strategies in Crops: Mechanisms, Synergistic Effects, and Sustainable Applications for Enhanced Secondary Metabolite Production

open access: yesFood Frontiers, Volume 7, Issue 4, July 2026.
This review analyzes single/combined abiotic (light, water, nutrients, hormones) and biotic (microbes, yeast) elicitors regulating signaling, gene expression, and metabolism to boost plant secondary metabolites. It highlights synergistic multielicitor strategies for crop quality and functional foods, while critically addressing current limitations and ...
Yifei Sun   +6 more
wiley   +1 more source

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