Results 61 to 70 of about 2,331 (162)
Vacuolization as a Novel Approach to Cancer Therapy
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak +9 more
wiley +1 more source
Spectroscopic characterization of hypericin and related compounds
, 1994 Absorbance and fluorescence spectra of hypericin were studied in a variety of solvents. Hypericin was found to be monomeric in most polar organic solvents, aggregated in non-polar solvents and water, and protonated in acidic solvents.
Wynn, Jeanne
core +1 more source
Clinical Medicine Insights: Case Reports, 2023 This case report describes the sudden presentation and successful cessation of psychiatric symptoms following the first administration of the Moderna mRNA vaccine against the SARS-CoV-2 virus during early 2021.
Daniel S Helman
doaj +1 more source
Advancements in Inorganic Chiral Nanomaterials for Anti‐Tumor Immunotherapy
Cancer Science, Volume 117, Issue 6, Page 1543-1553, June 2026.Schematic illustration of how inorganic chiral nanomaterials enhance immune activation to promote tumor cell elimination through targeted delivery, immunogenic cell death, and immune microenvironment modulation. ABSTRACT While the past decade has witnessed unprecedented technological advancements, cancer remains a major health threat, with conventional
Siyu Chen +9 more
wiley +1 more source
Hypericin: Single Molecule Spectroscopy of an Active Natural Drug
, 2020 Hypericin is one of the most efficient photosensitizers used in photodynamic tumor therapy (PDT). The reported treatments of this drug reach from antidepressive, antineoplastic, antitumor and antiviral activity.
Marc Brecht (1311258) +8 more
core +2 more sources
Variation in quantitative yield and hypericin content of St. John’s wort., Hypericum perforatum L.
Journal of Medicinal Plants, 2004 St John’s wort, Hypericum Perforatum L. (Culsiaceae) is an important medicinal plant, which has different bioactive constituents and hypericin (a naphtodianthrone) is one of this compounds.
H Naghdi Badi +6 more
doaj
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.Nitidine synergises with osimertinib in EGFR‐mutant NSCLC. Nitidine and osimertinib converge on HIF‐1α/FUNDC1‐mediated mitophagy. ABCB6 is required for the nitidine‐associated HIF‐1α/FUNDC1 response. Adaptive FUNDC1 downregulation sensitises osimertinib‐resistant cells to nitidine monotherapy.
Fan Xu +9 more
wiley +1 more source
Nano Select, Volume 7, Issue 5, May 2026.An all‐in‐one organic/inorganic hybrid theranostic nanosystem of PpIX + iron oxide nanoparticles combining synergistic PDT and PTT properties as well as optical and magnetic resonance imaging (MRI) T2 capabilities for image guided therapy is designed, characterized and evaluated in vitro.
Yiqian Wang +15 more
wiley +1 more source
Hypericin alleviates cerebral ischemia/reperfusion injury by modulating endoplasmic reticulum stress
Frontiers in PharmacologyIntroductionCerebral ischemia/reperfusion (I/R) injury remains a leading cause of neurological disability and is characterized by oxidative stress, calcium overload, inflammation, and endoplasmic reticulum (ER) stress following reperfusion.
Tingting Li, Chao Wang
doaj +1 more source
Comparative transcriptome reconstruction of four Hypericum species focused on hypericin biosynthesis
Frontiers in Plant Science, 2016 Next generation sequencing technology (NGS) rapidly developed research applications in thefield of plant functional genomics. Several Hypericum spp. with an aim to generate andenhance gene annotations especially for genes coding the enzymes supposedly ...
Miroslav Soták +6 more
doaj +1 more source