Results 131 to 140 of about 19,107 (290)

Atherectomy With Multimodal Embolic Protection for Severely Calcified Femoropopliteal Lesions

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Severe calcification in femoropopliteal lesions remains a clinical challenge to achieve both the technical and long‐term success in endovascular therapy. Although atherectomy is an effective treatment for calcified lesions, it is associated with the risk of distal embolization, even with the use of embolic protection devices (EPDs), and ...
Daichi Yoshii, Osamu Iida, Taku Toyoshima, Yoshiteru Okina   +3 more
wiley   +1 more source

Feasibility and Safety of the ETcath200 Robotic PCI System for Complex Coronary Lesions: A Prospective Single‐Center Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background International robotic‐assisted PCI platforms such as CorPath 200 and CorPath GRX have demonstrated procedural safety and efficacy but are limited by the absence of real‐time tactile feedback and cumbersome device exchange. The ETcath200, the first domestically developed robotic PCI system in China, introduces guidewire force‐sensing
Jing Yang, Yuqi Fang, Yizhu Yan, Zijing Liu, Jing Xie, Ge Zhang, Zhicheng Zhang, Tienan Sun, Guangyao Zhai   +8 more
wiley   +1 more source

Exploring the Anti‐Diabetic Potential of Anthocyanins: From Biochemical Pathways to Human Trials

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Diabetes mellitus (DM) is a global health challenge with increasing prevalence rates, particularly in low‐ and middle‐income countries. Anthocyanins (ACs) are potential bioactive compounds found in various fruits and vegetables, attracting the attention of researchers due to their possible role in managing diabetes and its complications ...
Lakshay Panchal, Sangeeta Yadav, Akash Kumar, Tanbeer Kaur, Yashna Bawa, Sarvesh Rustagi, Rahul Mehra   +6 more
wiley   +1 more source

Dose-Dependent Cholesterolemic Activity of Tocotrienols and α-Tocopherol [PDF]

, 2002
Tocotrienols and tocopherols are isoforms of vitamin E. Vitamin E may exhibit antioxidant, prooxidant and non-antioxidant activities depending upon circumstances.
Rajendran, Raajeswari, Teik, Khor Hun, Theng , Ng Theng   +2 more
core  

Molecular mechanism and rule of TCM prescriptions containing Alismatis Rhizoma in the clinical treatment of hyperlipidemia based on data mining and network pharmacology

, 2022
Ruohong JIANG, Xiangyue WEN, Yaming ZHANG, Xuehua Lu, XU Xiao-mei, Lisha Li, Rongqing Xu, Wenjin Lin   +7 more
openalex   +1 more source

Evaluation of the Therapeutic Potential of Bioactive Materials Based on a Complex of Oxidovanadium(IV) and Exopolysaccharide Levan in a Model of Insulin Resistance in Mice

ChemMedChem, EarlyView.
A low‐toxicity bioactive composition of oxidovanadium(IV) and exopolysaccharide levan is synthesized, characterized, and shown to reduce hyperglycemia, hypertriglyceridemia, and TyG index in a mice model of dexamethasone‐induced insulin resistance. Bioactive compositions containing vanadium complexes have been a viable strategy for constructing more ...
Amanda K. J. P. F. da Silva, Eucilene K. de L. B. Marques, Lidiane M. A. de Lima, Widarlane A. S. Alves, Dayane A. Gomes, Pedro L. Guzzo, Mônica F. Belian, Wagner E. Silva, Eduardo C. Lira   +8 more
wiley   +1 more source

Effects of Simultaneous Dietary Fish Oil Ingestion and Sulfur Amino Acid Supplementation on the Lipid Metabolism in Hepatoma-Bearing Rats with Hyperlipidemia

, 2010
Masashi Kawasaki, Yutaka Miura, Ryuhei Funabiki, Kazumi Yagasaki   +3 more
openalex   +2 more sources

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi, Benedetta Massetto, Megan Fitzgerald, Kha Le, Stanley Wang, Ifong Kan‐Eng, Meenakshi Venkatraman, Naqvi Mohammad, Lawrence Blatt, Tse‐I Lin, Sushmita M. Chanda, John Fry   +11 more
wiley   +1 more source

Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two‐treatment‐period, drug‐drug interaction study evaluated the effect of steady‐state asciminib on the pharmacokinetics of atorvastatin.
Matthias Hoch, Wendy Weis, Felix Huth, Seshulatha Jamalapuram, Michelle Quinlan, Amarnath Bandaru, Suleyman Eralp Bellibas, Asmae Mirkou, Shruti Kapoor, Shefali Kakar   +9 more
wiley   +1 more source

Unmet need in the hyperlipidaemia population with high risk of cardiovascular disease: a targeted literature review of observational studies [PDF]

, 2016

core   +1 more source