Results 71 to 80 of about 12,364 (198)

Targeted proteomics reveal histiocytosis‐associated neurodegeneration signatures

HemaSphere, Volume 10, Issue 9, September 2026.
Abstract Neurodegeneration (ND) is a severe complication of Langerhans cell histiocytosis (LCH), yet its underlying biology and reliable biomarkers remain poorly defined. The aim of this study was to (1) gain insight into neuroimmunological mechanisms governing ND and (2) assess the clinical value of established and novel biomarkers for ND‐LCH.
Egle Kvedaraite, Magda Lourda, Johannes Bastiaan Munting, Matthias Papo, Martin Jädersten, Yoko Shioda, Kenichi Sakamoto, Daniel Martín Muñoz, Panagiotis Andriopoulos, Francesco Pegoraro, Evaldas Laurencikas, Ingrid Kühnle, Joakim Wille, Leonie Naeije, Helena Olkinuora, Indranil Sinha, Daniel W. Hagey, Selma Olsson‐Åkefeldt, Fleur Cohen‐Aubart, Gustaf Österlundh, Mattias Svensson, Ahmed Idbaih, Fredrik Piehl, Kaj Blennow, Henrik Zetterberg, Tatiana Greenwood von Bahr, Désirée Gavhed, Akira Morimoto, Julien Haroche, Jan‐Inge Henter   +29 more
wiley   +1 more source

A novel practical equation for treatment of emergent hypernatremia and dehydration phase in infants

Journal of Research in Pharmacy Practice, 2017
Serum sodium (Na) concentration more than 145 mmol/L is defined as hypernatremia. Hypernatremia carries an acute morbidity and mortality, especially in neonates and infants.
Saba Ghaffary, Azadeh Moghaddas, Mehrnoush Dianatkhah   +2 more
doaj   +1 more source

Acetate‐ Versus Lactate‐Buffered Crystalloids for Prevention of Post‐ERCP Pancreatitis in Patients Without Access to Rectal NSAIDs: A Multicentre Double‐Blind Randomized Trial

United European Gastroenterology Journal, Volume 14, Issue 7, September 2026.
ABSTRACT Background Aggressive peri‐procedural intravenous fluid (IVF) therapy with lactated Ringer's solution (LR) reduces the risk of post‐ERCP pancreatitis (PEP), but the standard 8‐h protocol is impractical in outpatient settings and the optimal fluid type remains uncertain.
Woo Hyun Paik, Gunn Huh, Young Hoon Choi, Jin Ho Choi, In Rae Cho, Sang Hyub Lee, Ji Kon Ryu, Hwa Jung Kim, Taehyung Lee, Ce Hwan Park, Yoonchan Lee, Sung Hyun Cho, Dong‐Wan Seo, Kwang Hyuck Lee, Kyu Taek Lee, Jong Kyun Lee, Sunguk Jang, John Vargo, Steven Edmundowicz, Joo Kyung Park, Do Hyun Park   +20 more
wiley   +1 more source

Severe Hypernatraemia Secondary to Adipsia Associated With a Pituitary Macroadenoma in a Dog: A Case Report

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Severe hypernatraemia (Na+ 192 mmol/L) secondary to adipsia was successfully managed through gradual sodium correction, close monitoring and assisted water supplementation in a dog with a pituitary macroadenoma. No neurologic complications occurred during correction, and serum sodium concentrations remained stable for 9 months. This case highlights the
Gyo‐Bin Choo, Bum‐kyu Choi, Sooyoung Choi, Daji Noh, Ju‐Hyun An   +4 more
wiley   +1 more source

Serum sodium, tonicity, and risk of dementia in cohort and healthcare populations

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Identifying modifiable, accessible dementia risk factors is critical for prevention. Worldwide surveys indicate that about half of adults do not meet recommended fluid intake and may be chronically underhydrated. METHODS We examined associations between intracellular hydration markers and dementia risk in 13,535 participants from ...
Natalia I. Dmitrieva, Jonathan Rabinowitz, Eric S. Leifer, Delong Liu, Mona N. Bahouth, Manfred Boehm, Rebecca F. Gottesman   +6 more
wiley   +1 more source

Molecular Ontology Predicts Output Connections From the Nucleus of the Solitary Tract

Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.
The nucleus of the solitary tract (NTS) integrates visceral inputs to coordinate appetite and digestion, breathing, and cardiorespiratory reflexes. Using cell‐type‐specific tracing, we show that excitatory Lmx1b neurons project broadly to brainstem and forebrain targets, whereas inhibitory output remains largely brainstem‐restricted. Catecholaminergic (
Silvia Gasparini, Haidong Zhu, Ana Sofia Peraza Munuzuri, Mya L. Leuang, Frederico S. Fazan, Joel C. Geerling   +5 more
wiley   +1 more source

Rhabdomyolysis caused by hypernatremia.

, 2006
PubMedID: 17202646Rhabdomyolysis is a clinical picture which is rarely seen in children. In this case report here it is presented a patient who has biochemical and clinical signs of rhabdomyolysis and admitted to our clinic with hypernatremia.
Ozcan K., Incecik F., Yildizdas D., Herguner M.O., Altunbasak S.   +4 more
core   +1 more source

Open‐Label, Balanced, Randomized, Single‐Dose, Three‐Treatment, Three‐Sequence, Three‐Period, Three‐Way Crossover Oral Bioequivalence Study of Desmopressin Acetate Oral Solution

Clinical Pharmacology in Drug Development, Volume 15, Issue 8, August 2026.
ABSTRACT Desmopressin is first‐line therapy for central diabetes insipidus, also known as arginine vasopressin deficiency, but presents dosing challenges due to its narrow therapeutic index. This open‐label, randomized, three‐way crossover study evaluated the bioequivalence of a new desmopressin acetate oral solution (50 mcg/mL) compared to ...
Adam Christensen, Axay Parth, Mansi Kotak, Danka Radosavjevic, Catherine Gorman Moore, Byung‐Woun Seo   +5 more
wiley   +1 more source

Hypernatremia in two collodion babies

, 1989
Two cases of collodion babies with hypernatremia are presented, and the importance of this electrolyte abnormality in skin disorders is also ...
U Soyuer, S Kurtoğlu, E Aktaş, E Hasanoğlu   +3 more
core   +2 more sources

Do Antidepressants Lower the Prevalence of Lithium-Associated Hypernatremia and Symptomatic Polyuria in the Elderly?

Canadian Geriatrics Journal, 2013
Background Clinically important measures of lithium-induced nephrogenic diabetes insipidus (NDI) such as hypernatremia have not been well-studied. This is especially relevant for the elderly who, in comparison to younger adults, may become symptomatic ...
Soham Rej, Karl Looper, Marilyn Segal
doaj   +1 more source