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The Causes of Hypo- and Hyperphosphatemia in Humans
Calcified Tissue International, 2020Phosphate homeostasis involves several major organs that are the skeleton, the intestine, the kidney, and parathyroid glands. Major regulators of phosphate homeostasis are parathormone, fibroblast growth factor 23, 1,25-dihydroxyvitamin D, which respond to variations of serum phosphate levels and act to increase or decrease intestinal absorption and ...
Eugénie Koumakis+3 more
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Sucroferric oxyhydroxide for the treatment of hyperphosphatemia
Expert Opinion on Pharmacotherapy, 2018Sucroferric oxyhydroxide is a non-calcium, iron-based phosphate binder indicated for the treatment of hyperphosphatemia in patients with chronic kidney disease undergoing dialysis. Areas covered: Herein, the preclinical development and clinical data for sucroferric oxyhydroxide are reviewed, including the key data from the Phase III registration study ...
Jürgen Floege, Stuart M. Sprague
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Hyperphosphatemia in Lactic Acidosis
New England Journal of Medicine, 1977The initial clue to the presence of lactic acidosis is usually a physical sign such as Kussmaul breathing, a sudden change in mental status or the complex of signs associated with shock.
Keith L. Klein+2 more
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Hypophosphatemia and Hyperphosphatemia
Critical Care Clinics, 1991Pathophysiology, clinical sequelae, and treatment for hypophosphatemia and hyperphosphatemia are discussed. Hypophosphatemia results from a variety of conditions including malnutrition, carbohydrate refeeding, acid-base disorders, and hormonal and drug effects. Patients suffering from severe hypophosphatemia may present with a variety of syndromes that
Tusar K. Desai+2 more
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Hyperphosphatemia in a Burn Patient
Journal of Burn Care & Rehabilitation, 2001Hypophosphatemia has been observed in severely burned patients and has been associated with increased mortality. Hyperphosphatemia has rarely been described in this population. We present a burn patient with hyperphosphatemia, hypercalciuria, and suppressed parathyroid hormone level 5 months after the initial burn.
V D Bachelder, S G Muehlstedt, C L Smith
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An update on tenapanor to treat hyperphosphatemia
Drugs of Today, 2022Hyperphosphatemia is a common feature in patients with chronic kidney disease (CKD), especially in those with end-stage renal disease (ESRD). Commonly, high serum phosphate levels are observed only in later stages of CKD. The control of hyperphosphatemia plays a key role in the management of CKD patients.
Cianciolo G.+6 more
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Emerging drugs for hyperphosphatemia
Expert Opinion on Emerging Drugs, 2007Cardiovascular mortality is the leading cause of death in the uremic patient. Hyperphosphatemia is considered an independent risk factor associated with cardiovascular morbidity and mortality in dialysis patients. As phosphate control is not efficient with diet or dialysis, phosphate binders are commonly prescribed in patients with chronic renal ...
BELLINGHIERI, Guido+2 more
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Assessment of Hyperphosphatemia and Hypophosphatemia
Clinics in Laboratory Medicine, 1993Methodologic aspects including causes of factitious hyperphosphatemia and hypophosphatemia are summarized. The differential diagnosis of hyperphosphatemia is reviewed under its three broad causes: decreased glomerular filtration rate, increased exogenous or endogenous phosphate load, and increased renal tubular phosphate reabsorption.
Bourke E, Yanagawa N
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The syndrome of hyperostosis and hyperphosphatemia
The Journal of Pediatrics, 1981Six children, five girls and one boy, presented with recurrent episodes of swelling, pain, and tenderness of the long bones. On roentgenographic examination all had cortical hyperostosis of the affected areas. Serum phosphate concentration was persistently elevated, and calcium values were normal.
Rafic E. Melhem+2 more
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