Results 31 to 40 of about 34,346 (291)

Diffuse hyperpigmentation: A comprehensive approach

Pigment International, 2018
Skin color is determined by melanin and other chromophores and is influenced by physical factors (ultraviolet radiation) and other endocrine, autocrine, and paracrine factors.
Anupama Ghosh, Anupam Das, Rashmi Sarkar
doaj   +1 more source

Hyperpigmentation Induced by Hydroxychloroquine: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2019
Hydroxychloroquine is an antimalarial drug which is widely used in the treatment of rheumatoid arthritis, owing to its immunosuppressive and anti-inflammatory properties.
Bhanukumar Muthaiah, George Mathew Panachiyil, Tirin Babu   +2 more
doaj   +1 more source

Minocycline-induced retinal pigment epithelium hyperpigmentation masquerading as age-related macular degeneration: Case presentation and proposed mechanism

American Journal of Ophthalmology Case Reports
Purpose: We describe the case of an 80-year-old man with bilateral minocycline-induced retinal pigment epithelium (RPE) hyperpigmentation, which initially masqueraded as AMD.
Michael D. Yu, Nikhil Bommakanti, Yoshihiro Yonekawa, Jose Serafin Pulido   +3 more
doaj   +1 more source

Targeting delivery and minimizing epidermal diffusion of tranexamic acid by hyaluronic acid-coated liposome nanogels for topical hyperpigmentation treatment

Drug Delivery, 2021
Hyperpigmentation is a common complaint and distressing problem in dermatology, and tranexamic acid (TA) is an effective treatment agent but limited by the delivery to melanocytes in the epidermis.
Ying Liu, Yue Han, Tingting Zhu, Xianglei Wu, Wenxin Yu, Jiafang Zhu, Ying Shang, Xiaoxi Lin, Tianlan Zhao   +8 more
doaj   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Clinical and Demographic Characteristics of the Patients with Diffuse Hyperpigmentation

Southern Clinics of Istanbul Eurasia, 2020
INTRODUCTION[|]Hyperpigmentation is a condition characterized by the accumulation of pigment in the epidermis and dermis. Many dermatological diseases, such as primary cutaneous amyloidosis (PCA), postinflammatory hyperpigmentation (PIH), erythema ...
Ayşe Akbaş, Fadime Kılınç
doaj   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

Advanced Science, EarlyView.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
wiley   +1 more source

Identification of Compound Heterozygous CYP11A1 Variants via Reanalysis of Clinical Sequencing Data

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT A molecular diagnosis is currently achievable in approximately 50% of patients assessed by clinical geneticists at tertiary care centres. Next‐Generation Sequencing Panels contain a defined group of genes associated with a clinically defined set of phenotypes.
Ana Acosta Bedón, Vahid Akbari, Ralph Rothstein, Alexandra Inman, Sanjiv Bhalla, Jianghong An, Jan M. Friedman, Rosanna Weksberg, Cornelius Boerkoel, Steven J. M. Jones, William T. Gibson   +10 more
wiley   +1 more source

KDM2B‐Related Neurodevelopmental Disorder A Case‐Series Supporting the CxxC Domain Phenotype With Emphasis on Ocular and Dermatologic Features

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The KDM2B‐related neurodevelopmental disorder is a recently identified Mendelian disorder of the epigenetic machinery associated with pathogenic variants in KDM2B. Global developmental delay, intellectual disability, congenital anomalies, and systemic manifestations characterize the disorder.
Adriana Gomes, Álvaro Martín‐Rodríguez, Miguel Del Campo, Lynne M. Bird   +3 more
wiley   +1 more source

Pigmentary adverse effects of chemotherapeutic agents

Pigment International, 2019
Introduction: Skin and mucosa are most susceptible to the adverse effects of chemotherapeutic agents due to rapid rate of proliferation. A wide array of these adverse effects has been reported in patients undergoing chemotherapy.
Neerja Saraswat, Shekhar Neema, KPS Sengar   +2 more
doaj   +1 more source