Results 41 to 50 of about 41,070 (289)

Facial Cosmetic Therapy Use Among Patients With Systemic Sclerosis: An Australian Cohort Study

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is associated with numerous facial manifestations for which patients may engage in cosmetic therapies. It is unclear how patients with SSc use these therapies. This study sought to characterize patient engagement and experiences with cosmetic therapies for SSc‐related and non‐SSc–related facial changes.
Zachary Warren, Diane Apostolopoulos, Gene‐Siew Ngian, Amanda M. Saracino, Laura Ross, Nava Ferdowsi, Jennifer Walker, Cindy Hall, Kim Griggs, Susanna Proudman, Wendy Stevens, Joanne Sahhar   +11 more
wiley   +1 more source

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

Clinical and Demographic Characteristics of the Patients with Diffuse Hyperpigmentation

Southern Clinics of Istanbul Eurasia, 2020
INTRODUCTION[|]Hyperpigmentation is a condition characterized by the accumulation of pigment in the epidermis and dermis. Many dermatological diseases, such as primary cutaneous amyloidosis (PCA), postinflammatory hyperpigmentation (PIH), erythema ...
Ayşe Akbaş, Fadime Kılınç
doaj   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Hyperpigmentation Induced by Hydroxychloroquine: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2019
Hydroxychloroquine is an antimalarial drug which is widely used in the treatment of rheumatoid arthritis, owing to its immunosuppressive and anti-inflammatory properties.
Bhanukumar Muthaiah, George Mathew Panachiyil, Tirin Babu   +2 more
doaj   +1 more source

Diltiazem-Associated Hyperpigmentation [PDF]

Journal of General Internal Medicine, 2013
A 59-year-old African American female presented with a one-year history of progressive skin darkening. Her only symptom was mild itching. Medications included diltiazem 180 mg daily (extended release), prescribed three years earlier. Examination revealed blue-gray reticular hyperpigmentation in a photodistributed pattern on the face, neck, “V of the ...
Michelle, Campbell, Jesleen, Ahluwalia, Alice C, Watson   +2 more
openaire   +2 more sources

Bleomycin-induced flagellate hyperpigmentation [PDF]

, 2013
Bleomycin is a chemotherapeutic agent used in the treatment of different tumours. It has several side effects, including flagellate hyperpigmentation, which is a unique and a well-documented side effect of bleomycin therapy. We report a case of a 23-year-
Resende, C, Araújo, C, Gomes, J, Brito, C   +3 more
core   +2 more sources

Targeting delivery and minimizing epidermal diffusion of tranexamic acid by hyaluronic acid-coated liposome nanogels for topical hyperpigmentation treatment

Drug Delivery, 2021
Hyperpigmentation is a common complaint and distressing problem in dermatology, and tranexamic acid (TA) is an effective treatment agent but limited by the delivery to melanocytes in the epidermis.
Ying Liu, Yue Han, Tingting Zhu, Xianglei Wu, Wenxin Yu, Jiafang Zhu, Ying Shang, Xiaoxi Lin, Tianlan Zhao   +8 more
doaj   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Acquired macular hyperpigmentation an overview

, 2016
Acquired hyperpigmentation is always difficult to diagnose and more difficult to treat satisfactorily. There are many conditions which need to be considered before making a diagnosis of acquired macular hyperpigmentation like erythema dyschromicum ...
KH Mohan
core   +1 more source