Results 41 to 50 of about 43,659 (285)

Minocycline-induced retinal pigment epithelium hyperpigmentation masquerading as age-related macular degeneration: Case presentation and proposed mechanism

American Journal of Ophthalmology Case Reports
Purpose: We describe the case of an 80-year-old man with bilateral minocycline-induced retinal pigment epithelium (RPE) hyperpigmentation, which initially masqueraded as AMD.
Michael D. Yu, Nikhil Bommakanti, Yoshihiro Yonekawa, Jose Serafin Pulido   +3 more
doaj   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Clinical and Demographic Characteristics of the Patients with Diffuse Hyperpigmentation

Southern Clinics of Istanbul Eurasia, 2020
INTRODUCTION[|]Hyperpigmentation is a condition characterized by the accumulation of pigment in the epidermis and dermis. Many dermatological diseases, such as primary cutaneous amyloidosis (PCA), postinflammatory hyperpigmentation (PIH), erythema ...
Ayşe Akbaş, Fadime Kılınç
doaj   +1 more source

Hydroxyurea-induced hyperpigmentation with iron deposition [PDF]

, 2019
Hydroxyurea is a chemotherapeutic agent that is used in the treatment of various hematological diseases including chronic myelogenous leukemia, polycythemia vera, and sickle cell anemia. Hydroxyurea is also used to treat psoriasis.
Vangipuram, Ramya K, Koshelev, Misha V, Sanyal, Soma, Lee, Kevin P, Klimas, Natasha K, Soma Sanyal, Misha V Koshelev, Lee, Kevin P ; Vangipuram, Ramya K ; Klimas, Natasha K ; Sanyal, Soma ; Koshelev, Misha V, Ramya K Vangipuram, Kevin P Lee, Natasha K Klimas   +10 more
core   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Exosome‐mimetic vesicle‐encapsulated multi‐responsive antibacterial hydrogel core‐shell microneedle patch promotes scarless healing of infected wounds

BMEMat, EarlyView.
The core‐shell microneedle patch VP@FNV‐CuO2‐MN was fabricated by encapsulating n‐CuO2 in a moderately crosslinked PVA/CMCS/Borax4 hydrogel shell and VP‐loaded fibroblast membrane nanovesicles (VP@FNV) in a highly crosslinked PVA/CMCS/Borax6 hydrogel core. Upon application to an infected wound, the acidic microenvironment triggers Fenton‐like reactions
Ziwei Jiang, Huihui Zhang, Lianglong Chen, Zhangfeifan Yang, Sai Cao, Yufang He, Xiaoyang Liu, Siew Yee Wong, Xu Li, Hai Zhou, Ziyan Li, Zijun Zheng, Lei Yang   +12 more
wiley   +1 more source

Hyperpigmentation Induced by Hydroxychloroquine: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2019
Hydroxychloroquine is an antimalarial drug which is widely used in the treatment of rheumatoid arthritis, owing to its immunosuppressive and anti-inflammatory properties.
Bhanukumar Muthaiah, George Mathew Panachiyil, Tirin Babu   +2 more
doaj   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Targeting delivery and minimizing epidermal diffusion of tranexamic acid by hyaluronic acid-coated liposome nanogels for topical hyperpigmentation treatment

Drug Delivery, 2021
Hyperpigmentation is a common complaint and distressing problem in dermatology, and tranexamic acid (TA) is an effective treatment agent but limited by the delivery to melanocytes in the epidermis.
Ying Liu, Yue Han, Tingting Zhu, Xianglei Wu, Wenxin Yu, Jiafang Zhu, Ying Shang, Xiaoxi Lin, Tianlan Zhao   +8 more
doaj   +1 more source

Hydroxychloroquine-induced Hyperpigmentation [PDF]

The Journal of Rheumatology, 2020
About 10–25% of patients with systemic lupus erythematosus (SLE) managed with antimalarials will develop cutaneous hyperpigmentation, and although the majority of such cases is attributed to chloroquine, hydroxychloroquine (HCQ) is also implicated and is likely underrecognized1.
Amir Bajoghli, Gabriela Hernandez, Michael A. Cardis   +2 more
openaire   +2 more sources