Results 1 to 10 of about 40,078 (255)

PEG minocycline-liposomes ameliorate CNS autoimmune disease. [PDF]

PLoS ONE, 2009
Minocycline is an oral tetracycline derivative with good bioavailability in the central nervous system (CNS). Minocycline, a potent inhibitor of matrix metalloproteinase (MMP)-9, attenuates disease activity in experimental autoimmune encephalomyelitis ...
Wei Hu, Josbert Metselaar, Li-Hong Ben, Petra D Cravens, Mahendra P Singh, Elliot M Frohman, Todd N Eagar, Michael K Racke, Bernd C Kieseier, Olaf Stüve   +9 more
doaj   +2 more sources

Association of Early Minocycline Use with Secondary Infections in Patients with Severe Fever with Thrombocytopenia Syndrome: A Multicenter Retrospective Cohort Study [PDF]

Pathogens
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infection disease in which secondary infections may worsen clinical outcomes, particularly in severe cases.
Yuanyuan Zhang, Yuan Jiang, Xuya Yuan, Jingyi Wu, Ting Wu, Jun Cheng, Yuyao Li, Lingling He, Jiankang Zhang, Chun Zhang, Zhiping Pan, Mengyu Liu, Xuejiao Ma, Jihua Xue, Ying Ye, Jiabin Li, Lifen Hu   +16 more
doaj   +2 more sources

Minocycline ameliorates CNS autoimmunity through restraint of CD4+CD11bc+ cells [PDF]

Frontiers in Immunology
Minocycline is a tetracycline antibiotic with profound anti-inflammatory activity directed primarily against microglial cells and macrophages. Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as an important target of ...
Zorana Milosavljević, Milica Lazarević, Goran Stegnjaić, Neda Nikolovski, Ksenija Mirković, Dmitri Lodygin, Alexander Flügel, Đorđe Miljković, Suzana Stanisavljević, Bojan Jevtić   +9 more
doaj   +2 more sources

Prolonged minocycline treatment impairs motor neuronal survival and glial function in organotypic rat spinal cord cultures. [PDF]

PLoS ONE, 2013
BACKGROUND: Minocycline, a second-generation tetracycline antibiotic, exhibits anti-inflammatory and neuroprotective effects in various experimental models of neurological diseases, such as stroke, Alzheimer's disease, amyotrophic lateral sclerosis and ...
Josephine Pinkernelle, Hisham Fansa, Uwe Ebmeyer, Gerburg Keilhoff   +3 more
doaj   +1 more source

Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacter baumannii by destroy the outer membrane and enhance membrane potential in vitro

BMC Microbiology, 2022
Background Acinetobacter baumannii (A. baumannii) is an opportunistic pathogen and has emerged as one of the most troublesome pathogens. Drug resistance in A. baumannii has been reported on a global scale. Minocycline was found to be active against multi-
Tingting Guo, Xiaoli Sun, Jie Yang, Liying Yang, Mengying Li, Yuhang Wang, Hongmei Jiao, Guocai Li   +7 more
doaj   +1 more source

Characterization of the Interactions between Minocycline Hydrochloride and Trypsin with Spectroscopic and Molecular Docking Technology

Molecules, 2023
In the current study, the interaction of minocycline hydrochloride (MC) and trypsin (TRP) was studied using fluorescence spectroscopy, synchronous fluorescence spectroscopy, three-dimensional fluorescence spectroscopy, UV-Vis spectroscopy, and molecular ...
Xiaoxia Wang, Jisheng Sun, Litong Ma, Zhihua Nie, Huazheng Sai, Jianguo Cheng, Jianguo Duan   +6 more
doaj   +1 more source

Prediction of Minocycline Activity in the Gut From a Pig Preclinical Model Using a Pharmacokinetic -Pharmacodynamic Approach

Frontiers in Microbiology, 2021
The increase of multidrug-resistant (MDR) bacteria has renewed interest in old antibiotics, such as minocycline, that can be active against various MDR Gram-negative pathogens.
Quentin Vallé, Quentin Vallé, Béatrice B. Roques, Alain Bousquet-Mélou, David Dahlhaus, Felipe Ramon-Portugal, Véronique Dupouy, Delphine Bibbal, Aude A. Ferran   +8 more
doaj   +1 more source

Antimicrobial Effects of Minocycline, Tigecycline, Ciprofloxacin, and Levofloxacin against Elizabethkingia anophelis Using In Vitro Time-Kill Assays and In Vivo Zebrafish Animal Models

Antibiotics, 2021
Elizabethkingia anophelis is a multidrug-resistant pathogen. This study evaluated the antimicrobial activity of minocycline, tigecycline, ciprofloxacin, and levofloxacin using in vitro time-kill assays and in vivo zebrafish animal models.
Jiun-Nong Lin, Chung-Hsu Lai, Yi-Han Huang, Chih-Hui Yang   +3 more
doaj   +1 more source

Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review

Neural Regeneration Research, 2020
To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models. By searching in the databases of PubMed, ScienceDirect, and Scopus, and considering the inclusion and exclusion criteria of the study. Studies were included
Yazdan Naderi, Yunes Panahi, George E Barreto, Amirhosein Sahebkar   +3 more
doaj   +1 more source

Minocycline Treatment Reduces Mass and Force Output From Fast-Twitch Mouse Muscles and Inhibits Myosin Production in C2C12 Myotubes

Frontiers in Physiology, 2021
Minocycline, a tetracycline-class of antibiotic, has been tested with mixed effectiveness on neuromuscular disorders such as amyotrophic lateral sclerosis, autoimmune neuritis and muscular dystrophy.
Leonit Kiriaev, Ben D. Perry, David A. Mahns, Peter J. Shortland, Asma Redwan, John W. Morley, Stewart I. Head   +6 more
doaj   +1 more source