Results 1 to 10 of about 31,630 (212)
Drugs, 2012 Pharmacological interventions to treat psychiatric illness have previously focused on modifying dysfunctional neurotransmitter systems to improve symptoms. However, imperfect understanding of the aetiology of these heterogeneous syndromes has been associated with poor treatment outcomes for many individuals.
R N Brogden, T M Speight, G S Avery
exaly +5 more sources
Effects of minocycline on acrylamide-induced neurotoxicity in Wistar rats [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Acrylamide (ACR) causes neurotoxicity in animals and humans through oxidative stress, inflammation, and apoptosis. Male Wistar rats were used to evaluate the neuroprotective effects of minocycline on ACR-induced neurotoxicity. Materials and
Neda Vatankhah +3 more
doaj +2 more sources
Prolonged minocycline treatment impairs motor neuronal survival and glial function in organotypic rat spinal cord cultures. [PDF]
PLoS ONE, 2013 BACKGROUND: Minocycline, a second-generation tetracycline antibiotic, exhibits anti-inflammatory and neuroprotective effects in various experimental models of neurological diseases, such as stroke, Alzheimer's disease, amyotrophic lateral sclerosis and ...
Josephine Pinkernelle +3 more
doaj +1 more source
PEG minocycline-liposomes ameliorate CNS autoimmune disease. [PDF]
PLoS ONE, 2009 Minocycline is an oral tetracycline derivative with good bioavailability in the central nervous system (CNS). Minocycline, a potent inhibitor of matrix metalloproteinase (MMP)-9, attenuates disease activity in experimental autoimmune encephalomyelitis ...
Wei Hu +9 more
doaj +1 more source
BMC Microbiology, 2022 Background Acinetobacter baumannii (A. baumannii) is an opportunistic pathogen and has emerged as one of the most troublesome pathogens. Drug resistance in A. baumannii has been reported on a global scale. Minocycline was found to be active against multi-
Tingting Guo +7 more
doaj +1 more source
Molecules, 2023 In the current study, the interaction of minocycline hydrochloride (MC) and trypsin (TRP) was studied using fluorescence spectroscopy, synchronous fluorescence spectroscopy, three-dimensional fluorescence spectroscopy, UV-Vis spectroscopy, and molecular ...
Xiaoxia Wang +6 more
doaj +1 more source
Frontiers in Microbiology, 2021 The increase of multidrug-resistant (MDR) bacteria has renewed interest in old antibiotics, such as minocycline, that can be active against various MDR Gram-negative pathogens.
Quentin Vallé +8 more
doaj +1 more source
The blues of minocycline [PDF]
QJM, 2011 A 74-year-old female patient with a history of coronary artery disease, hypertension and peripheral vascular disease was admitted with an upper gastrointestinal bleed. She also had a long history of rheumatoid arthritis with the characteristic features of the hands (Figure 1A). She was on minocycline for her rheumatoid arthritis for ∼8 years.
A, Mahta, S, Kesari
openaire +2 more sources
Antibiotics, 2021 Elizabethkingia anophelis is a multidrug-resistant pathogen. This study evaluated the antimicrobial activity of minocycline, tigecycline, ciprofloxacin, and levofloxacin using in vitro time-kill assays and in vivo zebrafish animal models.
Jiun-Nong Lin +3 more
doaj +1 more source
Neuroprotective effects of minocycline on focal cerebral ischemia injury: a systematic review
Neural Regeneration Research, 2020 To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal models. By searching in the databases of PubMed, ScienceDirect, and Scopus, and considering the inclusion and exclusion criteria of the study. Studies were included
Yazdan Naderi +3 more
doaj +1 more source