Results 21 to 30 of about 40,078 (255)

Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline [PDF]

, 2010
Previous studies of the effects of coenzyme Q10 and minocycline on mouse models of Huntington’s disease have produced conflicting results regarding their efficacy in behavioral tests.
Brunner Daniela, Menalled Liliana B., Brunner, D., Signer Ethan, Liliana B Menalled, Benjamin Zahasky, Ragland Natalie, Tobin Allan J., Allan J Tobin, Larry Park, Ragland, N., Minnich, J., Leeds, J., Daniela Brunner, Jennifer Goodman, Zahasky, B., Signer, E., Leeds Janet, Howland David, Zahasky Benjamin, Goodman, J., Tobin, A.J., Patry Monica, Minnich Jennie, Ethan Signer, Goodman Jennifer, Patry, M., Menalled, L.B., Lowden, Philip A.S., Jennie Minnich, Park Larry, Phillip A S Lowden, Howland, D., Park, L., Janet Leeds, Monica Patry, Lowden Phillip A. S., David Howland, Natalie Ragland   +38 more
core   +2 more sources

Minocycline suppresses interleukine-6, its receptor system and signaling pathways and impairs migration, invasion and adhesion capacity of ovarian cancer cells: in vitro and in vivo studies. [PDF]

PLoS ONE, 2013
Interleukin (IL)-6 has been shown to be a major contributing factor in growth and progression of ovarian cancer. The cytokine exerts pro-tumorigenic activity through activation of several signaling pathways in particular signal transducer and activator ...
Parvin Ataie-Kachoie, David L Morris, Mohammad H Pourgholami   +2 more
doaj   +1 more source

Minocycline and antipsychotics inhibit inflammatory responses in BV-2 microglia activated by LPS via regulating the MAPKs/ JAK-STAT signaling pathway

BMC Psychiatry, 2023
Background Abnormal activation of microglia is involved in the pathogenesis of schizophrenia. Minocycline and antipsychotics have been reported to be effective in inhibiting the activation of microglia and thus alleviating the negative symptoms of ...
Yujun Long, Ying Wang, Yidong Shen, Jing Huang, Yamin Li, Renrong Wu, Jingping Zhao   +6 more
doaj   +1 more source

Analgesic and anti-inflammatory effects of minocycline in chicks [PDF]

Iraqi Journal of Veterinary Sciences
Minocycline is a second-generation tetracycline that has a variety of nonantimicrobial properties. This study aimed to assess the analgesic and anti-inflammatory activities of minocycline in chicks.
Yasser M. Albadrany, Ahmed S. Naser, Khalid A. Shaaban   +2 more
doaj   +1 more source

Minocycline markedly reduces acute visceral nociception via inhibiting neuronal ERK phosphorylation

Molecular Pain, 2012
Background Minocycline prevents the development of neuropathic and inflammatory pain by inhibiting microglial activation and postsynaptic currents. But, how minocycline obviates acute visceral pain is unclear.
Cho Ik-Hyun, Lee Min Jung, Jang Minhee, Gwak Nam Gil, Lee Ka Yeon, Jung Hyuk-Sang   +5 more
doaj   +1 more source

Better together? Treating traumatic brain injury with minocycline plus N-acetylcysteine

Neural Regeneration Research, 2022
Traumatic brain injury has a complex pathophysiology that produces both rapid and delayed brain damage. Rapid damage initiates immediately after injury. Treatment of traumatic brain injury is typically delayed many hours, thus only delayed damage can be ...
Siobhán Lawless, Peter J Bergold
doaj   +1 more source

Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline

Neurobiology of Disease, 2007
Minocycline has been shown to be neuroprotective in ischemic and neurodegenerative disease models and could potentially be relevant for clinical use.
Roland Månsson, Magnus J. Hansson, Saori Morota, Hiroyuki Uchino, Christine T. Ekdahl, Eskil Elmér   +5 more
doaj   +1 more source

Minocycline in phenotypic models of Huntington's disease

Neurobiology of Disease, 2005
Minocycline has been shown to be neuroprotective in various models of neurodegenerative diseases. However, its potential in Huntington's disease (HD) models characterized by calpain-dependent degeneration and inflammation has not been investigated. Here,
Kadiombo Bantubungi, Carine Jacquard, Anita Greco, Annita Pintor, Abdelwahed Chtarto, Khalid Tai, Marie-Christine Galas, Liliane Tenenbaum, Nicole Déglon, Patrizia Popoli, Luisa Minghetti, Emmanuel Brouillet, Jacques Brotchi, Marc Levivier, Serge N. Schiffmann, David Blum   +15 more
doaj   +1 more source

Mechanisms involved in chronic neuropathic pain after avulsion injury [PDF]

, 2010
PhDMotor vehicle accidents are the most common cause of injuries involving avulsion of spinal roots from the brachial or lumbosacral plexuses. This results in chronic intractable pain that is refractory to pharmacotherapy.
Chew, Daniel John
core   +2 more sources

In vitro and in vivo efficacy of minocycline-based therapy for Elizabethkingia anophelis and the impact of reduced minocycline susceptibility

, 2022
[[abstract]]Objectives: Elizabethkingia anophelis is inherently resistant to multiple antibiotics, except minocycline. This study aimed to determine the in vitro and in vivo efficacy of minocycline monotherapy and combination therapy against susceptible ...
Yang, YS;Huang, TW;Huang, YC;Huang, WC;Hsu, SY;Wu, HC;Chen, FJ;Shang, HS;Sytwu, HK;Kuo, SC
core   +1 more source