Minocycline markedly reduces acute visceral nociception via inhibiting neuronal ERK phosphorylation
Molecular Pain, 2012 Background Minocycline prevents the development of neuropathic and inflammatory pain by inhibiting microglial activation and postsynaptic currents. But, how minocycline obviates acute visceral pain is unclear.
Cho Ik-Hyun +5 more
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Better together? Treating traumatic brain injury with minocycline plus N-acetylcysteine
Neural Regeneration Research, 2022 Traumatic brain injury has a complex pathophysiology that produces both rapid and delayed brain damage. Rapid damage initiates immediately after injury. Treatment of traumatic brain injury is typically delayed many hours, thus only delayed damage can be ...
Siobhán Lawless, Peter J Bergold
doaj +1 more source
Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]
, 2019 In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María +13 more
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Minocycline is cytoprotective in human corneal endothelial cells and induces anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and X-linked inhibitor of apoptosis (XIAP) [PDF]
, 2010 Introduction Loss of corneal endothelial cells (CECs) is one major factor limiting transplant clarity and survival after keratoplasty. Amongst other factors, apoptosis due to cellular stress is responsible for these problems.
Hirneiß, Christoph +3 more
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Tetracycline Actions Relevant to Rosacea Treatment [PDF]
, 2009 Until today, the pathogenesis of rosacea is not known in detail. Yet in recent years evidence has been accumulating that rosacea with its common symptoms such as inflammatory lesions, erythema, telangiectasia, phymatous changes, and ocular symptoms is of
Korting, Hans Christian, Schöllmann, C.
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TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice [PDF]
, 2017 The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated.
Chiurchiù, Valerio +16 more
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Neurobiology of Disease, 2007 Minocycline has been shown to be neuroprotective in ischemic and neurodegenerative disease models and could potentially be relevant for clinical use.
Roland Månsson +5 more
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Minocycline in phenotypic models of Huntington's disease
Neurobiology of Disease, 2005 Minocycline has been shown to be neuroprotective in various models of neurodegenerative diseases. However, its potential in Huntington's disease (HD) models characterized by calpain-dependent degeneration and inflammation has not been investigated. Here,
Kadiombo Bantubungi +15 more
doaj +1 more source
Anti-apoptotic effects of minocycline on doxorubicin-induced cardiotoxicity in male Wistar rats [PDF]
مجله علمی دانشگاه علوم پزشکی کردستان, 2023 Background and Aim: Doxorubicin is an effective chemotherapeutic agent. However, use of this drug is limited due to its dose-dependent cardiotoxicity. Activation of apoptotic pathways in myocardial tissue plays an important role in doxorubicin- induced ...
Hossein Piri +4 more
doaj
Successful Treatment of Acute Prostatitis Caused by Multidrug-Resistant Escherichia coli With Tigecycline Monotherapy [PDF]
, 2020 We present a successful treatment, with tigecycline monotherapy, of acute prostatitis caused by multidrug-resistant Escherichia coli harboring an NDM-1 carbapemenase along with a CMY-2 cephalosporinase and a TEM ...
Babouee Flury, Baharak +7 more
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