Results 11 to 20 of about 31,630 (212)

Minocycline Treatment Reduces Mass and Force Output From Fast-Twitch Mouse Muscles and Inhibits Myosin Production in C2C12 Myotubes

Frontiers in Physiology, 2021
Minocycline, a tetracycline-class of antibiotic, has been tested with mixed effectiveness on neuromuscular disorders such as amyotrophic lateral sclerosis, autoimmune neuritis and muscular dystrophy.
Leonit Kiriaev, Ben D. Perry, David A. Mahns, Peter J. Shortland, Asma Redwan, John W. Morley, Stewart I. Head   +6 more
doaj   +1 more source

Minocycline suppresses interleukine-6, its receptor system and signaling pathways and impairs migration, invasion and adhesion capacity of ovarian cancer cells: in vitro and in vivo studies. [PDF]

PLoS ONE, 2013
Interleukin (IL)-6 has been shown to be a major contributing factor in growth and progression of ovarian cancer. The cytokine exerts pro-tumorigenic activity through activation of several signaling pathways in particular signal transducer and activator ...
Parvin Ataie-Kachoie, David L Morris, Mohammad H Pourgholami   +2 more
doaj   +1 more source

Testicular Pain Associated With Minocycline Use

Urology Case Reports, 2015
Two males ages 16 and 23 years presented with new testicular pain while taking minocycline. Both patients experienced resolution of their symptoms only after minocycline discontinuation. Testicular pain with minocycline use has been previously described,
Victor Kucherov, William Hulbert, Guan Wu   +2 more
doaj   +1 more source

Minocycline and antipsychotics inhibit inflammatory responses in BV-2 microglia activated by LPS via regulating the MAPKs/ JAK-STAT signaling pathway

BMC Psychiatry, 2023
Background Abnormal activation of microglia is involved in the pathogenesis of schizophrenia. Minocycline and antipsychotics have been reported to be effective in inhibiting the activation of microglia and thus alleviating the negative symptoms of ...
Yujun Long, Ying Wang, Yidong Shen, Jing Huang, Yamin Li, Renrong Wu, Jingping Zhao   +6 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Analgesic and anti-inflammatory effects of minocycline in chicks [PDF]

Iraqi Journal of Veterinary Sciences
Minocycline is a second-generation tetracycline that has a variety of nonantimicrobial properties. This study aimed to assess the analgesic and anti-inflammatory activities of minocycline in chicks.
Yasser M. Albadrany, Ahmed S. Naser, Khalid A. Shaaban   +2 more
doaj   +1 more source

Minocycline markedly reduces acute visceral nociception via inhibiting neuronal ERK phosphorylation

Molecular Pain, 2012
Background Minocycline prevents the development of neuropathic and inflammatory pain by inhibiting microglial activation and postsynaptic currents. But, how minocycline obviates acute visceral pain is unclear.
Cho Ik-Hyun, Lee Min Jung, Jang Minhee, Gwak Nam Gil, Lee Ka Yeon, Jung Hyuk-Sang   +5 more
doaj   +1 more source

Better together? Treating traumatic brain injury with minocycline plus N-acetylcysteine

Neural Regeneration Research, 2022
Traumatic brain injury has a complex pathophysiology that produces both rapid and delayed brain damage. Rapid damage initiates immediately after injury. Treatment of traumatic brain injury is typically delayed many hours, thus only delayed damage can be ...
Siobhán Lawless, Peter J Bergold
doaj   +1 more source

Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline

Neurobiology of Disease, 2007
Minocycline has been shown to be neuroprotective in ischemic and neurodegenerative disease models and could potentially be relevant for clinical use.
Roland Månsson, Magnus J. Hansson, Saori Morota, Hiroyuki Uchino, Christine T. Ekdahl, Eskil Elmér   +5 more
doaj   +1 more source

Minocycline in phenotypic models of Huntington's disease

Neurobiology of Disease, 2005
Minocycline has been shown to be neuroprotective in various models of neurodegenerative diseases. However, its potential in Huntington's disease (HD) models characterized by calpain-dependent degeneration and inflammation has not been investigated. Here,
Kadiombo Bantubungi, Carine Jacquard, Anita Greco, Annita Pintor, Abdelwahed Chtarto, Khalid Tai, Marie-Christine Galas, Liliane Tenenbaum, Nicole Déglon, Patrizia Popoli, Luisa Minghetti, Emmanuel Brouillet, Jacques Brotchi, Marc Levivier, Serge N. Schiffmann, David Blum   +15 more
doaj   +1 more source