Results 31 to 40 of about 40,078 (255)

Anti-apoptotic effects of minocycline on doxorubicin-induced cardiotoxicity in male Wistar rats [PDF]

مجله علمی دانشگاه علوم پزشکی کردستان, 2023
Background and Aim: Doxorubicin is an effective chemotherapeutic agent. However, use of this drug is limited due to its dose-dependent cardiotoxicity. Activation of apoptotic pathways in myocardial tissue plays an important role in doxorubicin- induced ...
Hossein Piri, Ehsan Aali, Samaneh Keshavarz Hedayati, Sanaz Keshavarz Shahbaz, Yazdan Naderi   +4 more
doaj  

Minocycline-based therapy for carbapenem-resistant Acinetobacter baumannii pneumonia: A multicenter retrospective study

International Journal of Infectious Diseases
Background: Minocycline is one of the few antibiotics that remain highly effective against carbapenem-resistant Acinetobacter baumannii (CRAB). However, the efficacy of minocycline for treating CRAB pneumonia has not been clearly demonstrated yet ...
Hyeri Seok, Si-Ho Kim, Hye Jin Shi, Won Suk Choi, Dae Won Park, Yu Mi Wi, Cheon-Hoo Jeon, Yoonseon Park, Shin Hee Hong, Kyungmin Huh   +9 more
doaj   +1 more source

Minocycline accelerates hypoxia-inducible factor-1 alpha degradation and inhibits hypoxia-induced neovasculogenesis through prolyl hydroxylase, von Hippel-Lindau-dependent pathway

, 2017
Hypoxia-mediated stress responses are important in tumor progression, especially when tumor growth causes the tumor to become deprived of its blood supply.
康照洲, Li, Ching-Hao;Liao, Po-Lin;Yang, Ya-Ting;Huang, Shih-Hsuan;Lin, Cheng-Hui;Cheng, Yu-Wen;Kang, Jaw-Jou   +1 more
core   +1 more source

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

Periodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera, Arie Jan van Winkelhoff, Paula Matesanz, Katalina Lauwens, Wim Teughels   +4 more
wiley   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Minocycline Nanocrystals: A New Approach for Treating Acne with Reduced Systemic Side Effects

Pharmaceutics
Background/Objectives: Acne vulgaris is a chronic skin infection characterized by high sebum secretion, keratosis around hair follicles, inflammation, and imbalance in androgen levels. Acne vulgaris causes permanent scars or skin pigmentation in cases of
Suha M. Abudoleh, Juhaina M. Abu Ershaid, Dima Lafi, Nisreen A. Dahshan, Ahmad Talhouni, Amjad Abuirmeileh   +5 more
doaj   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Minocycline for Controlling Neuropathic Pain: A Systematic Narrative Review of Studies in Humans

Journal of Pain Research, 2021
Dong Ah Shin,1 Tae Uk Kim,2 Min Cheol Chang3 1Department of Neurosurgery, Yonsei University, College of Medicine, Seoul, Republic of Korea; 2Department of Physical Medicine and Rehabilitation, College of Medicine, Dankook University, Cheonan, Republic of
Shin DA, Kim TU, Chang MC
doaj  

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Minocycline decreases CCR2-positive monocytes in the retina and ameliorates photoreceptor degeneration in a mouse model of retinitis pigmentosa.

PLoS ONE, 2021
Retinal inflammation accelerates photoreceptor cell death caused by retinal degeneration. Minocycline, a semisynthetic broad-spectrum tetracycline antibiotic, has been previously reported to rescue photoreceptor cell death in retinal degeneration.
Ryo Terauchi, Hideo Kohno, Sumiko Watanabe, Saburo Saito, Akira Watanabe, Tadashi Nakano   +5 more
doaj   +1 more source