Results 31 to 40 of about 53,842 (242)

Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications. [PDF]

, 2017
Current therapeutic approaches to depression fail for millions of patients due to lag in clinical response and non-adherence. Here we provide new support for the antidepressant effect of an anesthetic drug, ketamine, by Inverse-Frequency Analysis of ...
Abagyan, Ruben, Atayee, Rabia, Cohen, Isaac V, Makunts, Tigran   +3 more
core   +2 more sources

Minocycline-based therapy for carbapenem-resistant Acinetobacter baumannii pneumonia: A multicenter retrospective study

International Journal of Infectious Diseases
Background: Minocycline is one of the few antibiotics that remain highly effective against carbapenem-resistant Acinetobacter baumannii (CRAB). However, the efficacy of minocycline for treating CRAB pneumonia has not been clearly demonstrated yet ...
Hyeri Seok, Si-Ho Kim, Hye Jin Shi, Won Suk Choi, Dae Won Park, Yu Mi Wi, Cheon-Hoo Jeon, Yoonseon Park, Shin Hee Hong, Kyungmin Huh   +9 more
doaj   +1 more source

Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. [PDF]

, 2018
ObjectiveInhibitors of the voltage-gated K+ channel Kv1.3 are currently in development as immunomodulators for the treatment of autoimmune diseases. As Kv1.3 is also expressed on microglia and has been shown to be specifically up-regulated on "M1-like ...
Azam, Beeton, Beschorner, Campanella, Chen, Chen, Chen, Courties, DeCoursey, Duque, Fadool, Fordyce, Fu, Gazula, Hu, Iadecola, Jacobs, Jin, Kaushal, Kawabori, Kettenmann, Khanna, Kundu-Raychaudhuri, Longa, Lyons, Macrez, Maezawa, Maezawa, Matheu, Meisel, Murray, Nguyen, Noraberg, Pannasch, Peng, Pennington, Pereira, Price, Rangaraju, Rangaraju, Rus, Ryck, Schlattmann, Schlichter, Schmitz, Tarcha, Tarcha, Wang, Wulff, Wulff   +49 more
core   +2 more sources

A rare case of melanosis of the hard palate mucosa in a patient with chronic myeloid leukemia [PDF]

, 2015
Imatinib Mesylate, also known as Gleevec or ST1-571, is a tyrosine-kinase inhibitor used as the gold standard medication for the chronic myeloid leukemia (CML); Imatinib has indeed deeply revolutionized the CML therapy allowing most patients to have a ...
Bosco, Daniela, Fantozzi, Paolo Junior, Palaia, Gaspare, Romeo, Umberto, Tenore, Gianluca   +4 more
core   +3 more sources

Diffuse skin hyperpigmentation associated with chronic minocycline use in a patient with prosthetic joint infection

IDCases, 2017
Cutaneous hyperpigmentation is a recognized adverse effect of chronic minocycline use occurring in up to 50% of patients. In this report we present a rare case of extensive skin hyperpigmentation involving both lower extremities in a patient receiving ...
Hadi Berbari, Elie F. Berbari, Irene G. Sia   +2 more
doaj   +1 more source

Minocycline Nanocrystals: A New Approach for Treating Acne with Reduced Systemic Side Effects

Pharmaceutics
Background/Objectives: Acne vulgaris is a chronic skin infection characterized by high sebum secretion, keratosis around hair follicles, inflammation, and imbalance in androgen levels. Acne vulgaris causes permanent scars or skin pigmentation in cases of
Suha M. Abudoleh, Juhaina M. Abu Ershaid, Dima Lafi, Nisreen A. Dahshan, Ahmad Talhouni, Amjad Abuirmeileh   +5 more
doaj   +1 more source

Minocycline for Controlling Neuropathic Pain: A Systematic Narrative Review of Studies in Humans

Journal of Pain Research, 2021
Dong Ah Shin,1 Tae Uk Kim,2 Min Cheol Chang3 1Department of Neurosurgery, Yonsei University, College of Medicine, Seoul, Republic of Korea; 2Department of Physical Medicine and Rehabilitation, College of Medicine, Dankook University, Cheonan, Republic of
Shin DA, Kim TU, Chang MC
doaj  

Minocycline decreases CCR2-positive monocytes in the retina and ameliorates photoreceptor degeneration in a mouse model of retinitis pigmentosa.

PLoS ONE, 2021
Retinal inflammation accelerates photoreceptor cell death caused by retinal degeneration. Minocycline, a semisynthetic broad-spectrum tetracycline antibiotic, has been previously reported to rescue photoreceptor cell death in retinal degeneration.
Ryo Terauchi, Hideo Kohno, Sumiko Watanabe, Saburo Saito, Akira Watanabe, Tadashi Nakano   +5 more
doaj   +1 more source

Minocycline intra-bacterial pharmacokinetic hysteresis as a basis for pharmacologic memory and a backbone for once-a-week pan-tuberculosis therapy

Frontiers in Pharmacology, 2022
Background: There is need for shorter duration regimens for the treatment of tuberculosis, that can treat patients regardless of multidrug resistance status (pan-tuberculosis).Methods: We combined minocycline with tedizolid, moxifloxacin, and rifampin ...
Devyani Deshpande, Shashikant Srivastava, Jotam Garaimunashe Pasipanodya, Tawanda Gumbo, Tawanda Gumbo   +4 more
doaj   +1 more source

Classification Framework and Structure-Activity-Relationship (SAR) of Tetracycline-Structure-Based Drugs

, 2012
By studying the literature about Tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are known, especially against bacteria, while against other targets, they are
Bortolotto, Carlotti, Chen, Chopra, De Luigi, Doershuk, Duivenvoorden, Dutta, Lambs, McNamara, Nelson, Nelson, Silvia, Stetler-Steveson, Tang, Thong, Wainwright, Yrjanheikki   +17 more
core   +2 more sources