Results 61 to 70 of about 567,888 (305)

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice.

Cell, 1996
SUMMARY Targeted disruption of the murine p27(Kip1) gene caused a gene dose-dependent increase in animal size without other gross morphologic abnormalities.
M. Fero, Mick Rivkin, M. Tasch, P. Porter, C. Carow, E. Firpo, K. Polyak, Li-Huei Tsai, V. C. Broudy, R. Perlmutter, K. Kaushansky, James M. Roberts   +11 more
semanticscholar   +1 more source

Should duration of dual antiplatelet therapy depend on the type and/or potency of implanted stent? A pre-specified analysis from the PROlonging Dual antiplatelet treatment after Grading stent-induced Intimal hyperplasia studY (PRODIGY)

, 2013
The purpose of this pre-specified analysis of the PROlonging Dual antiplatelet treatment after Grading stent-induced Intimal hyperplasia studY (PRODIGY) was to assess device-specific outcomes relative to different duration of dual antiplatelet therapy ...
TEBALDI, Matteo, Marco Valgimigli, Pascal Vranckx, for the PROlonging Dual antiplatelet treatment after Grading stent induced Intimal hyperplasia studY Investigators, BORGHESI, Marco, FERRARI, Roberto, Giovanni Parrinello   +6 more
core   +1 more source

Endometrial Hyperplasia and Endometrial Carcinoma [PDF]

, 2020
Endometrial hyperplasia and endometrial carcinoma are rare in young women, but the incidence is continually increasing in developed countries due to obesity and metabolic diseases.
Wimberger, Pauline, Maren Goeckenjan, von Wolff, Michael, Michael von Wolff, Goeckenjan, Maren, Pauline Wimberger   +5 more
core   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Successful development of squamous cell carcinoma and hyperplasia in RGEN-mediated p27 KO mice after the treatment of DMBA and TPA

Laboratory Animal Research, 2018
To evaluate the carcinogenicity of p27 knockout (KO) mice with RNA-guided endonuclease (RGENs)-mediated p27 mutant exon I gene (IΔ), alterations in the carcinogenic phenotypes including tumor spectrum, tumor suppressor proteins, apoptotic proteins and ...
Jun Young Choi, Woo Bin Yun, Ji Eun Kim, Mi Rim Lee, Jin Ju Park, Bo Ram Song, Hye Ryeong Kim, Ji Won Park, Mi Ju Kang, Byeong Cheol Kang, Han-Woong Lee, Dae Youn Hwang   +11 more
doaj   +1 more source

Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline.

Journal of Clinical Endocrinology and Metabolism, 2010
OBJECTIVE We developed clinical practice guidelines for congenital adrenal hyperplasia (CAH). PARTICIPANTS The Task Force included a chair, selected by The Endocrine Society Clinical Guidelines Subcommittee (CGS), ten additional clinicians experienced ...
P. Speiser, R. Azziz, L. Baskin, L. Ghizzoni, T. Hensle, D. Merke, H. Meyer-Bahlburg, W. L. Miller, V. Montori, S. Oberfield, M. Ritzén, P. White   +11 more
semanticscholar   +1 more source

Clinical, genetic, and functional characterization of four patients carrying partial loss-of-function mutations in the steroidogenic acute regulatory protein (StAR) [PDF]

, 2010
Context: Nonclassic congenital lipoid adrenal hyperplasia (lipoid CAH) is a recently recognized disorder caused by mutations in the steroidogenic acute regulatory protein (StAR) that retain partial function.
Miller, W. L., Lang-Muritano, M., Soccio, R. E., Miller, W L, Sahakitrungruang, T, Walker, J. M., Miller, WL, Walker, J M, Achermann, J. C., Achermann, JC, Lang-Muritano, M, Sahakitrungruang, T., Achermann, J C, Walker, JM, Soccio, R E, Soccio, RE   +15 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Unilateral Condylar Hyperplasia: Two Case Reports and a Literature Review

Oman Medical Journal, 2021
Condylar hyperplasia (CH) is a rare idiopathic condition affecting the mandibular condyle where the growth of the condylar head and/or neck continues beyond the normal growth period.
Amur Al Senaidi, Ahmed Al Hashmi, Mohammed Al Ismaili, Abdulaziz Bakathir   +3 more
doaj   +1 more source

The global burden of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: A systematic review and meta-analysis

Scientific Reports, 2017
Benign prostatic hyperplasia is a common non-malignant condition among older men, but the epidemiology is poorly characterised. We summarised and determined the global prevalence of benign prostatic hyperplasia.
Shaun Wen Huey Lee, E. Chan, Y. K. Lai
semanticscholar   +1 more source