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Macro, Micro, and Molecular. Changes of the Osteochondral Interface in Osteoarthritis Development
Frontiers in Cell and Developmental Biology, 2021 Osteoarthritis (OA) is a long-term condition that causes joint pain and reduced movement. Notably, the same pathways governing cell growth, death, and differentiation during the growth and development of the body are also common drivers of OA.
Xiwei Fan +6 more
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Frontiers in Cell and Developmental Biology, 2019 A major problem with chondrocytes derived in vitro from stem cells is undesired hypertrophic degeneration, to which articular chondrocytes (ACs) are resistant. As progenitors of all adult tissues, induced pluripotent stem cells (iPSCs) are in theory able
Solvig Diederichs +3 more
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Adaptations to Post-exercise Cold Water Immersion: Friend, Foe, or Futile?
Frontiers in Sports and Active Living, 2021 In the last decade, cold water immersion (CWI) has emerged as one of the most popular post-exercise recovery strategies utilized amongst athletes during training and competition.
Mohammed Ihsan +3 more
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Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy [PDF]
, 2013 BACKGROUND: Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of protein translation and has been implicated in the control of muscle mass ...
Handschin, Christoph +23 more
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Concentric left ventricular remodeling and aortic stiffness: a comparison of obesity and hypertension. [PDF]
, 2013 BACKGROUND: Increased thoracic ascending aortic stiffness is thought to contribute to concentric left ventricular hypertrophy and increased mortality, a pattern seen in hypertension.
Francis, JM +15 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundCardiomyocyte‐specific transgenic mice overexpressing S100A6, a member of the family of EF‐hand calcium‐binding proteins, develop less cardiac hypertrophy, interstitial fibrosis, and myocyte apoptosis after permanent coronary ligation, findings
Azadeh Mofid +13 more
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Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States
Cell Reports, 2020 Summary: Loading of skeletal muscle changes the tissue phenotype reflecting altered metabolic and functional demands. In humans, heterogeneous adaptation to loading complicates the identification of the underpinning molecular regulators.
Tanner Stokes +13 more
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Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise
Cells, 2021 This study describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8–12 ...
Wenyuan G. Zhu +8 more
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