Results 41 to 50 of about 422,010 (294)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Of mice and men: Pinpointing species differences in adipose tissue biology

Frontiers in Cell and Developmental Biology, 2022
The prevalence of obesity and metabolic diseases continues to rise, which has led to an increased interest in studying adipose tissue to elucidate underlying disease mechanisms. The use of genetic mouse models has been critical for understanding the role
Emma Börgeson, Emma Börgeson, Emma Börgeson, Jeremie Boucher, Jeremie Boucher, Carolina E. Hagberg, Carolina E. Hagberg   +6 more
doaj   +1 more source

Hypertrophy of the Brain [PDF]

The Journal of Nervous and Mental Disease, 1907
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openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Combining ECG Criteria for Left Ventricular Hypertrophy Improves Risk Prediction in Patients With Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundPatients with hypertension with ECG left ventricular hypertrophy (LVH) have higher cardiovascular morbidity and mortality, but single ECG criteria may underestimate risk.
Peter M. Okin, Darcy A. Hille, Sverre E. Kjeldsen, Richard B. Devereux   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Prognostic value of left ventricular mass index in patients with mild and moderate aortic stenosis

Кардиоваскулярная терапия и профилактика, 2019
Aim. To study the prognostic value of Left Ventricular Mass (LVM) with asymptomatic aortic stenosis (AS) in a long-term outpatient study, as well as the effect of the LVM on major cardiovascular events (CVe).Material and methods.
A. S. Ryazanov, M. V. Makarovskaya, K. I. Kapitonov, A. A. Kudryavtsev   +3 more
doaj   +1 more source

Whole-slide image analysis outperforms micrograph acquisition for adipocyte size quantification

Adipocyte, 2020
The distinction between biological processes of adipose tissue expansion is crucial to understanding metabolic derangements, but a robust method for quantifying adipocyte size has yet to be standardized.
Anne S Maguire, Lauren N Woodie, Robert L Judd, Douglas R Martin, Michael W Greene, Emily C Graff   +5 more
doaj   +1 more source

Expression of Estrogen Receptor Alpha and Evaluation of Histological Degeneration Scores in Fibroblasts of Hypertrophied Ligamentum Flavum: A Qualitative Study

Biomolecules, 2021
The most common spinal disorder in elderly is lumbar spinal stenosis (LSS), resulting partly from ligamentum flavum (LF) hypertrophy. Its pathophysiology is not completely understood.
Christina C. Westhoff, Christian-Dominik Peterlein, Hanna Daniel, Juergen R. Paletta, Roland Moll, Annette Ramaswamy, Stefan Lakemeier   +6 more
doaj   +1 more source

Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy [PDF]

, 2013
BACKGROUND: Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of protein translation and has been implicated in the control of muscle mass ...
Handschin, Christoph, Bentzinger, C. Florian, Guridi, Maitea, Castets, Perrine, Hall, Michael N, Tintignac, Lionel A., Hall, Michael N., Perrine Castets, Romanino, Klaas, Tintignac, Lionel, Rüegg, Markus A, Michael N Hall, Lin, Shuo, Markus A Rüegg, Bentzinger, C Florian, Christoph Handschin, Serge Summermatter, Summermatter, Serge, C Bentzinger, Klaas Romanino, Maitea Guridi, Shuo Lin, Rüegg, Markus A., Lionel A Tintignac, Lin S, Castets P, Rüegg MA, Bentzinger CF, Tintignac, Lionel A, Guridi M, Tintignac LA, Summermatter S, Hall MN, Romanino K, Handschin C   +34 more
core   +1 more source