Results 41 to 50 of about 549,472 (306)

Risk factors for obstructive sleep apnea syndrome in children: state of the art [PDF]

, 2019
The obstructive sleep apnea syndrome (OSAS) represents only part of a large group of pathologies of variable entity called respiratory sleep disorders (RSD) which include simple snoring and increased upper airway resistance syndrome (UARS).
Bellini, Chiara, Cammaroto, G., Colizza, A., de Vincentiis, M., De Vito, A., Firinu, E., Gobbi, R., Greco, A., Gulotta, G., Iannella, G., Magliulo, G., Meccariello, G., Pace, A., Pelucchi, S., Polimeni, A., Vicini, C., Visconti, I. C.   +16 more
core   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Combining ECG Criteria for Left Ventricular Hypertrophy Improves Risk Prediction in Patients With Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundPatients with hypertension with ECG left ventricular hypertrophy (LVH) have higher cardiovascular morbidity and mortality, but single ECG criteria may underestimate risk.
Peter M. Okin, Darcy A. Hille, Sverre E. Kjeldsen, Richard B. Devereux   +3 more
doaj   +1 more source

Heat shock transcription factor 1 preserves cardiac angiogenesis and adaptation during pressure overload [PDF]

, 2008
To examine how heat shock transcription factor 1 (HSF1) protects against maladaptive hypertrophy during pressure overload, we subjected HSF1 transgenic (TG), knockout (KO) and wild type (WT) mice to a constriction of transverse aorta (TAC), and found ...
Aijun Sun, Aili Guan, Akira Nakai, Hong Jiang, Hong Ma, Hui Gong, Issei Komuro, Jie Yuan, Jiming Li, Junbo Ge, Lingyan Yuan, Ning Zhou, Yanyan Liang, Yuhong Niu, Yunzeng Zou, Yuqi Wang, Zhen Ma   +16 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Myocardial Hibernation in Patients with Arterial Hypertension and Ischemic Heart Disease as a Cause of Heart Failure

Львівський клінічний вісник, 2013
Introduction. Myocardial hibernation refers to “new ischemic syndromes,” which in recent years have increasingly attracted the attention of cardiologists and cardiac surgeons.
Barnett O. , Kyyak Y., Kyyak H., Kovalyshyn V., Besh D.   +4 more
doaj   +1 more source

Of mice and men: Pinpointing species differences in adipose tissue biology

Frontiers in Cell and Developmental Biology, 2022
The prevalence of obesity and metabolic diseases continues to rise, which has led to an increased interest in studying adipose tissue to elucidate underlying disease mechanisms. The use of genetic mouse models has been critical for understanding the role
Emma Börgeson, Emma Börgeson, Emma Börgeson, Jeremie Boucher, Jeremie Boucher, Carolina E. Hagberg, Carolina E. Hagberg   +6 more
doaj   +1 more source

The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy [PDF]

, 2010
The interactions between pressure and volume overload that occur in hypertension lead to different patterns of cardiac hypertrophy and to increase in natriuretic peptides (NPs).
Cavallero, Carmen Susana, Cerrudo, Carolina Susana, Fernandez, Belisario Enrique, Hertig, Cecilia Margarita, Rodríguez Fermepin, Martin   +4 more
core  

Clinical significance of the buccal fat pad: how to determine the correct surgical indications based on preoperative analysis [PDF]

, 2018
Background: Despite the multitude of clinical and aesthetic uses, the correct surgical indications for buccal fat pad (BFP) removal have yet to be fully elucidated.
Bencardino, Davide, Fallico, Nefer, Maccioni, Francesca, Monarca, Cristiano, Ribuffo, Diego, Tarallo, Mauro, Taranto, Giuseppe Di   +6 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source