Results 21 to 30 of about 549,472 (306)

Chondral Differentiation of Induced Pluripotent Stem Cells Without Progression Into the Endochondral Pathway

Frontiers in Cell and Developmental Biology, 2019
A major problem with chondrocytes derived in vitro from stem cells is undesired hypertrophic degeneration, to which articular chondrocytes (ACs) are resistant. As progenitors of all adult tissues, induced pluripotent stem cells (iPSCs) are in theory able
Solvig Diederichs, Felicia A. M. Klampfleuthner, Babak Moradi, Wiltrud Richter   +3 more
doaj   +1 more source

Glycogen synthase kinases 3α and 3β in cardiac myocytes: regulation and consequences of their inhibition [PDF]

, 2008
Inhibition of glycogen synthase kinase 3β (GSK3β) as a consequence of its phosphorylation by protein kinase B/Akt (PKB/Akt) has been implicated in cardiac myocyte hypertrophy in response to endothelin-1 or phenylephrine.
Alsafi, Ali, Clerk, Angela, Cullingford, Timothy E., Fuller, Stephen John, Giraldo Ramirez, Alejandro, Markou, Thomais, Sugden, Peter H., Weiss, Sophie C.   +7 more
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Adaptations to Post-exercise Cold Water Immersion: Friend, Foe, or Futile?

Frontiers in Sports and Active Living, 2021
In the last decade, cold water immersion (CWI) has emerged as one of the most popular post-exercise recovery strategies utilized amongst athletes during training and competition.
Mohammed Ihsan, Mohammed Ihsan, Chris R. Abbiss, Robert Allan   +3 more
doaj   +1 more source

Mechanisms of exercise-induced improvements in the contractile apparatus of the mammalian myocardium [PDF]

, 2010
One of the main outcomes of aerobic endurance exercise training is the improved maximal oxygen uptake, and this is pivotal to the improved work capacity that follows the exercise training.
Adams, Adams, American College of Sports Medicine Position Stand, American Heart Association, Amundsen, Anderson, Anversa, Beisvag, Belardinelli, Bergmann, Bers, Beyer, Blair, Blair, Boluyt, Bossuyt, Bye, Care, de Waard, Del Monte, Diffee, Diffee, Diffee, Diffee, Eto, Fletcher, Frampton, Gledhill, Gomez, Gulati, Hambrecht, Hambrecht, Haram, Hasenfuss, Helgerud, Hunter, Iemitsu, Jensen, Jolliffe, Kavanagh, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kemi, Kodoma, Kong, Kuum, Lankford, Laughlin, Lee, Levine, Liang, Liu, Loennechen, McMullen, Moholdt, Mokelke, Mole, Moore, Musch, Myers, Myles, Nakao, Natali, O’Connor, O’Neill, Paffenbarger, Palmer, Pelliccia, Penpargkul, Pluim, Richardson, Richardson, Rognmo, Saltin, Schaible, Schjerve, Shephard, Stolen, Tanasescu, Tate, Tibbits, Tjonna, Venetucci, Wagner, Wilkins, Wisloff, Wisloff, Wisloff, Wisloff, Wisloff, Wisloff, Zhang, Zhang   +98 more
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The role of reactive astrocitose in the chronological evolution of traumatic brain injury [PDF]

, 2018
Introduction and objectives. This study aims to investigate whether the cerebral modifications of posttraumatic reactive astrocitose can be considered an objective criterion for determining the age of traumatic cranio-cerebral lesions.
Belis, Vladimir, Calota, Relu G., Costescu, Mihnea, Duncea-Borca, Roxana M., Kutasi, Reka, Moldovan, Cosmin A.   +5 more
core   +4 more sources

Ileal hypertrophy and associated true diverticulum as a cause of colic in a horse [PDF]

, 2017
A 4-year-old Thoroughbred gelding underwent an explorative celiotomy for a suspected small intestinal obstruction. During surgery, an impacted diverticulum of the ileum was suspected, necessitating a jejunocaecostomy. The owner opted for euthanasia.
Assenza, Hooper, Robertson, Van Kruiningen, Van Kruiningen, Verwilghen, Weaver, Yovich   +7 more
core   +3 more sources

Cardiac Overexpression of S100A6 Attenuates Cardiomyocyte Apoptosis and Reduces Infarct Size After Myocardial Ischemia‐Reperfusion

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundCardiomyocyte‐specific transgenic mice overexpressing S100A6, a member of the family of EF‐hand calcium‐binding proteins, develop less cardiac hypertrophy, interstitial fibrosis, and myocyte apoptosis after permanent coronary ligation, findings
Azadeh Mofid, Nadav S. Newman, Paul J. H. Lee, Cynthia Abbasi, Pratiek N. Matkar, Dmitriy Rudenko, Michael A. Kuliszewski, Hao H. Chen, Kolsoom Afrasiabi, James N. Tsoporis, Anthony O. Gramolini, Kim A. Connelly, Thomas G. Parker, Howard Leong‐Poi   +13 more
doaj   +1 more source

Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States

Cell Reports, 2020
Summary: Loading of skeletal muscle changes the tissue phenotype reflecting altered metabolic and functional demands. In humans, heterogeneous adaptation to loading complicates the identification of the underpinning molecular regulators.
Tanner Stokes, James A. Timmons, Hannah Crossland, Thomas R. Tripp, Kevin Murphy, Chris McGlory, Cameron J. Mitchell, Sara Y. Oikawa, Robert W. Morton, Bethan E. Phillips, Steven K. Baker, Phillip J. Atherton, Claes Wahlestedt, Stuart M. Phillips   +13 more
doaj   +1 more source

Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise

Cells, 2021
This study describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8–12 ...
Wenyuan G. Zhu, Jamie E. Hibbert, Kuan Hung Lin, Nathaniel D. Steinert, Jake L. Lemens, Kent W. Jorgenson, Sarah M. Newman, Dudley W. Lamming, Troy A. Hornberger   +8 more
doaj   +1 more source

Time spent with cats is never wasted: Lessons learned from feline acromegalic cardiomyopathy, a naturally occurring animal model of the human disease [PDF]

, 2018
BackgroundIn humans, acromegaly due to a pituitary somatotrophic adenoma is a recognized cause of increased left ventricular (LV) mass. Acromegalic cardiomyopathy is incompletely understood, and represents a major cause of morbidity and mortality.
A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Colao, A Mestron, A Piovesan, AC Dirtu, AM Pereira, B Posch, BJ Maron, BPP Meij, BR Bond, C Paige, C-Y Liu, CJL Little, CR Lamb, David B. Church, David J. Connolly, DJ Connolly, F Fracassi, G Jacobs, G Lombardi, G Lombardi, J Dal, J Gilbert, JA Myers, JK Sangster, JM Fletcher, JR Payne, JT Lie, Kieran Borgeat, LJ Wilkie, Lois Wilkie, M Galderisi, M Lesser, M Maxie Grant, M Nishiki, M Rosca, M-LL Jaffrain-Rea, MD Kittleson, ME Peterson, ME Peterson, NJ Pereira, Norelene Harrington, NS Moise, NS Moise, O Kershaw, OM Dekkers, P Menaut, PR Fox, PR Fox, PR Fox, PR Fox, PR Fox, R Baldelli, R Gostelow, R Pivonello, RC Weichselbaum, S Brown, S Fazio, S Fazio, S Fazio, S Fieffe, S Murarka, S Niessen, SJM Niessen, SJM Niessen, SJM Niessen, SK Liu, SK Liu, Stijn J. M. Niessen, SV Keyte, T Wagner, T. Rosol, Vincenzo Lionetti, Virginia Luis Fuentes, WL McGuffin   +80 more
core   +2 more sources