Results 121 to 130 of about 630,671 (289)

Involvement of interleukin-3 in delayed-type hypersensitivity

, 1998
The in vivo functions of interleukin-3 (IL-3) were investigated by generating IL-3-deficient mice. Although hematopoiesis was unimpaired in homozygous mutant animals, contact hypersensitivity reactions were compromised.
Mihm, M, Beissert, S, Mulligan, R C, Mach, Nicolas, Reznikoff, G, Granstein, R, Lantz, C S, Small, C, Sadelain, M, Dranoff, G, Galli, S J   +10 more
core   +1 more source

A composite, host‐participatory haustorium links host compatibility to defence bifurcation in Alectra vogelii (Orobanchaceae)

PLANTS, PEOPLE, PLANET, EarlyView.
Parasitic weeds of the family Orobanchaceae are among the most damaging constraints on food production in the tropics, draining water and nutrients from their hosts and threatening the livelihoods of millions of smallholder farmers. Yellow witchweed (Alectra vogelii) can destroy entire legume harvests across sub‐Saharan Africa, where these crops are a ...
Hildah Kithinji, Guillaume Brun, Susann Wicke   +2 more
wiley   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source

Benefits and Harms of Herbal Medicines for Preventing and Treating Acute Respiratory Infections: An Overview of Systematic Reviews

Phytotherapy Research, EarlyView.
Overview of systematic reviews evaluating the benefits and harms of herbal medicines for management of ARIs. ABSTRACT Hundreds of herbal medicines are currently marketed for the management of acute respiratory infections (ARIs). However, there is uncertainty about their benefits and harms, and clinical guidance remains unclear.
Fariba Aghajafari, Brian Choi, Devansh Bhatt, Susanna Maltoni, Elizabeth T. Thomas, Elena C. Rosca, Sara Gandini, Annette Plüddemann, Carl J. Heneghan, John M. Conly, Tom Jefferson, Igho J. Onakpoya   +11 more
wiley   +1 more source

Purpurin Alleviates Chemotherapy‐Induced Thrombocytopenia Through Estrogen Receptor α Dependent Phosphoinositide 3‐Kinase/Protein Kinase B Signalling

Phytotherapy Research, EarlyView.
Schematic overview of the in vitro and in vivo evaluation of purpurin in promoting MK maturation and platelet production, through ESR1/PI3K/AKT. ABSTRACT Chemotherapy‐induced thrombocytopenia (CIT) increases bleeding risk and compromises chemotherapy delivery.
Xiaolin Gan, Xinle Wang, Lu Hao, Xiaoqin Tang, Zhixuan Liu, Long Wang, Xiang Xie, Xiang Li, Chunling Zhao, Yan Li, Xinwu Huang, Yuanzhi Liu, Jianming Wu   +12 more
wiley   +1 more source

The Inverse Koebner Phenomenon in Cutaneous T‐Cell Lymphomas

JEADV Clinical Practice, EarlyView.
Alba Guglielmo, Corrado Zengarini, Alessandro Borghi, Alessandro Pileri   +3 more
wiley   +1 more source

Pregnancy in CTD‐interstitial lung disease: Current evidence, clinical challenges, and a proposed management algorithm

Rheumatology &Autoimmunity, EarlyView.
Summary of pregnancy management in CTD‐ILD across preconception, antenatal, and postpartum phases, emphasizing risk stratification and multidisciplinary care. 6MWT, 6‐min walk test; CTD‐ILD: connective tissue disease‐interstitial lung disease; DLCO, diffusion capacity of the lung for carbon monoxide; FVC, forced vital capacity; MDT, multidisciplinary ...
Khaled Aldhuaina, Ghaydaa Aldabie, Mohammad Abdulsalam, Ali Jawad   +3 more
wiley   +1 more source

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source

Bidirectional Plant‐Microneedle Responses to Guide Biomaterial Design

Small, EarlyView.
We examine bidirectional interactions between plants and polymeric microneedles to develop effective compound delivery strategies. Material chemistry and architecture determine stability in the plant environment, cargo–matrix interactions, and the magnitude and duration of the plant response. Plant microneedles should therefore be designed as a coupled
Sally Shuxian Koh, Meng Li, Kasey Goh, Yunteng Cao, Yangyang Han, Raju Cheerlavancha, Liang Cui, Benedetto Marelli, Daisuke Urano   +8 more
wiley   +1 more source

Biomaterial Platforms for Spatiotemporal Control of mRNA Delivery in Tissue Engineering and Regenerative Medicine: Design Rules, Therapeutic Applications, and Translational Roadmap

Small, EarlyView.
Biomaterial platforms can control where and when mRNA‐encoded proteins are expressed to support tissue repair. This Review proposes a cargo–target–timing framework linking therapeutic function, target tissues and cells, and expression profiles with carrier and scaffold design.
Huachun Pan, Shumin Yang, Katarina Holubova, Huifang Yin, Hongbo Chen, Xintian Zheng, Xiangan Han, Jinqiu Zhang, Xueping Li, Hui Zhang, Xiaojun Cai, Václav Slovák, Lihong Zhang, Quan Mo, Quazi T. H. Shubhra   +14 more
wiley   +1 more source