Results 131 to 140 of about 77,830 (301)

Inflammasome Activation in Delayed-Type Hypersensitivity Reactions

, 2007
The inflammasome is a protein complex cleaving the pro-inflammatory cytokines IL-1β and IL-18 into their active forms by caspase-1 activation. The cytosolic protein complex can be activated by danger signals, such as bacterial and viral components, ATP ...
Yazdi, Amir S., Ghoreschi, Kamran, Röcken, Martin   +2 more
core   +1 more source

Synthesis and Characterization of Novel Silylated Sm3+ and Eu3+ Complexes Incorporated Into Mesoporous Silica Nanoparticles

European Journal of Inorganic Chemistry, EarlyView.
The strategy of incorporating the Eu(tta‐Si)3(phen) and Sm(tta‐Si)3(phen)2 complexes prevented leaching of the complexes and preserved their intrinsic optical properties. Preliminary studies of silylated Ln3+ complexes and nanoparticles loaded with these complexes demonstrated cytotoxicity against cancer cells, with minimal cytotoxic effect on nontumor
Juliana Jorge, Jaqueline Rodrigues da Silva, Diego Boldo, Kristiane Fanti Del Pino Santos, Luana da Silva Oliveira, Adriana Pereira Duarte, Gustavo Rocha de Castro, Ariadna Lafourcade Prada, Jesús Rafael Rodríguez Amado, Marc Verelst, Vasilii Khripun, Marco Antonio Utrera Martines   +11 more
wiley   +1 more source

Mutation type‐specific transcriptomic signatures and readthrough therapy rescue in SMC1A‐related developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to investigate the molecular consequences of pathogenic variants in the SMC1A gene—particularly those associated with developmental and epileptic encephalopathy (DEE85)—and to evaluate the therapeutic potential of ataluren in restoring SMC1A function and mitigating disease‐related transcriptomic and genomic ...
Maddalena Di Nardo, Francesca Sardina, Maria M. Pallotta, Iñigo Marcos‐Alcalde, Paulino Gómez‐Puertas, Cinzia Rinaldo, Ian D. Krantz, Antonio Musio   +7 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

MACROPHAGE AGGREGATION IN VITRO: A NEW ASSAY FOR DELAYED HYPERSENSITIVITY.

, 1972
MACROPHAGE AGGREGATION IN VITRO: A NEW ASSAY FOR DELAYED ...
SOMSAK. LOLEKHA (7965788)
core  

Hypersensitivity reaction risk when restarting cenobamate after discontinuation: Insights from a prolonged hospitalized cohort

Epilepsia Open, EarlyView.
Abstract Objective To evaluate the risk of hypersensitivity reactions, including dermatological rashes, when cenobamate (CNB) is restarted at maintenance doses after temporary discontinuation. Methods We leveraged the natural experiment of long antiseizure medication discontinuation during intracranial EEG evaluation and conducted a retrospective ...
Marina Feldman, Andreas Alexopoulos, Juan Bulacio, Dileep Nair, Vineet Punia   +4 more
wiley   +1 more source

Effects of high‐moisture extrusion processing on reducing anti‐nutritional factors and allergenicity in plant‐based materials—A mini review

Food Biomacromolecules, EarlyView.
Abstract The rising demand for plant‐based meat alternatives has had advancements in processing technologies such as extrusion to meet consumer preferences for enhanced sensory qualities and nutritional benefits. High moisture extrusion (HME), a thermo‐mechanical process employing elevated moisture levels (40%–70%), has emerged as a promising method ...
Nur Hameedah Binte Ramadhan, Yuzhu Mao, Juan Du   +2 more
wiley   +1 more source

Management of Radiodermatitis in Patients With Head and Neck Cancer Undergoing Radiotherapy: A Scoping Review

Health Care Science, EarlyView.
The data obtained through this review highlight the lack of global consensus among radiotherapy centers on the best topical treatment for radiodermatitis. It indicates that the choice of treatment depends on professional judgment due to the absence of standardized guidelines, pointing to the need for more robust scientific research to develop effective
Tâmara Taynah Medeiros da Silva, Louise Constancia de Melo Alves Silva, Thatiane Evelyn de Lima Fernandes, Karena Cristina da Silva Leal, Thaís Brunna Maurício Pinheiro, Guilherme Moises Alves Fernandes, Kátia Regina Barros Ribeiro, Daniele Vieira Dantas, Rodrigo Assis Neves Dantas   +8 more
wiley   +1 more source

Malignant melanoma. Delayed hypersensitivity skin testing.

, 1979
One hundred eighty-two patients undergoing initial surgical therapy for primary malignant melanoma were evaluated for delayed hypersensitivity using a battery of recall antigens prior to surgery.
Roses, D F, Campion, John F, MD, Harris, M N, Gumport, S L   +3 more
core  

Understanding Autistic Young Adults' Perceptions and Experiences of Traumatic and Stressful Events

Journal of Clinical Psychology, Volume 81, Issue 6, Page 445-461, June 2025.
ABSTRACT Objectives The aim of this study was to explore how young autistic adults experience and respond to stressful life events, and the relationship between autistic characteristics and symptoms of stress associated with these events. Methods Using an exploratory sequential mixed‐methods approach, an online qualitative survey was first administered
Alliyza Lim, Robyn L. Young
wiley   +1 more source