Results 191 to 200 of about 7,575 (253)
The FEBS Journal, EarlyView.The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati +4 more
wiley +1 more source
Transgenic selection and underlying mechanisms in apicomplexan parasites
The FEBS Journal, EarlyView.Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju +2 more
wiley +1 more source
The FEBS Journal, EarlyView.Vitamin B6 is a critical molecule for plant metabolism and development. Rsr4‐1, a loss‐of‐function mutant in a vitamin B6 biosynthesis gene, has a distinct short root phenotype. Here we describe five novel suppressor mutants with an rsr4‐1 background that have normalized root growth and distinct phenotypic and molecular characteristics, representing a ...
Marcelina Parra +4 more
wiley +1 more source
Allergic Contact Dermatitis With Erythema Multiforme‐Like Features Induced by Isoconazole Nitrate
Contact Dermatitis, EarlyView.
Giorgia Sbarra +5 more
wiley +1 more source
Gender, Work &Organization, EarlyView.ABSTRACT The need to undergo fertility treatment to fulfill parenthood aspirations involves many challenges in professional and personal domains. Extant scholarship has tended to focus on the identity threats and individual experiences of the challenges involved, but research has not delved into the more relational experiences that may characterize ...
Céire Gilsenan +3 more
wiley +1 more source
Final Analysis of the Phase 1/2 Trial of Valoctocogene Roxaparvovec for Severe Haemophilia A
Haemophilia, EarlyView.ABSTRACT Introduction Valoctocogene roxaparvovec is an adeno‐associated virus vector serotype 5 (AAV5)‐mediated gene therapy for severe haemophilia A (HA). Aim Report the final safety and efficacy results of the phase 1/2 trial of valoctocogene roxaparvovec. Methods An open‐label phase 1/2 trial (NCT02576795) enrolled adult males with severe HA (factor
Priyanka Raheja +9 more
wiley +1 more source
Defining the Role of Nurses in Gene Therapy for Haemophilia
Haemophilia, EarlyView.Abstract Introduction Haemophilia is a rare bleeding disorder now undergoing a major shift in care as gene therapy (GT), delivered through viral‑vector in vivo gene transfer, has enabled adults with haemophilia A or B to stop prophylaxis with minimal bleeding.
Greta Mulders +5 more
wiley +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objectives/Background There is growing evidence that migraine is associated with attentional abnormalities, both during and between attacks, potentially affecting the cognitive processing of sensory stimulation. However, the underlying neurophysiological mechanism remains poorly understood.
Rémy Masson +6 more
wiley +1 more source