Results 41 to 50 of about 149 (148)

Genital Crohn's disease in pediatrics and genetic associations

JPGN Reports, EarlyView.
Abstract Genital edema is a rare presentation of Crohn's disease (CD), also known as metastatic CD (MCD). This may precede, co‐occur with, or follow gastrointestinal symptoms and present a diagnostic challenge. We aimed to characterize the features, clinical courses, pathogenesis, and outcomes of patients with MCD to increase understanding and promote ...
Erica Chang, Caroline Chinchilla Putzeys, Edward Hoffenberg, Ashish Patel, Elizabeth Hilow, Brad Pasternak   +5 more
wiley   +1 more source

Phase I/II Trial of Perioperative Avelumab in Combination With Chemoradiation in the Treatment of Stage II/III Resectable Esophageal and Gastroesophageal Junction Cancer

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Standard treatment of patients with stage II/III esophageal or gastroesophageal junction (E/GEJ) cancer involves neoadjuvant chemoradiation (nCRT), resection, and immunotherapy. Our trial evaluated the addition of perioperative avelumab to standard treatments.
Nataliya V. Uboha, Mustafa M. Basree, Jens C. Eickhoff, Dustin A. Deming, Kristina Matkowskyj, James Maloney, Daniel McCarthy, Malcolm DeCamp, Noelle LoConte, Philip B. Emmerich, Sean Kraus, Monica A. Patel, Jeremy D. Kratz, Sam J. Lubner, Newton Hurst, Michael F. Bassetti   +15 more
wiley   +1 more source

Quantitative Dynamic Contrast‐Enhanced Ultrasound Confirms Renal Obstruction

Journal of Ultrasound in Medicine, EarlyView.
Objectives To evaluate dynamic contrast‐enhanced ultrasound (DCEUS) potential for diagnosing ureteropelvic junction obstruction (UPJO). We hypothesize that DCEUS can identify differences in renal parenchymal microcirculation between normal and obstructed kidneys.
Kourosh Kalayeh, Sapan N. Ambani, Man Zhang, Stephanie Daignault‐Newton, Benjamin L. Viglianti, Rashmi Mediratta, William W. Schultz, J. Brian Fowlkes, Bryan S. Sack   +8 more
wiley   +1 more source

Nasal Mucosa Regeneration After Reboot Surgery: Electron Microscopy and Histology Insights in CRSwNP

The Laryngoscope, EarlyView.
CRSwNP often requires multiple treatments, with monoclonal antibodies (mAbs) and endoscopic sinus surgeries used to manage resistant cases. This study focused on five patients undergoing reboot surgery, analyzing mucosal regeneration through biopsies and clinical outcomes over 24 months. It revealed complete non‐scarred regeneration of the nasal mucosa,
Francesca Pirola, Elena Vezzoli, Andrea Falqui, Francesco Giombi, Enrico Heffler, Giuseppe Mercante, Giuseppe Spriano, Fabio Grizzi, Luca Malvezzi   +8 more
wiley   +1 more source

Nutritional priorities to support GLP‐1 therapy for obesity: A joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society

Obesity, EarlyView.
Abstract Background Glucagon‐like peptide 1 receptor agonists and combination medications (hereafter collectively referred to as GLP‐1s) are shifting the treatment landscape for obesity. However, real‐world challenges and limited clinician and public knowledge on nutritional and lifestyle interventions can limit GLP‐1 efficacy, equitable results, and ...
Dariush Mozaffarian, Monica Agarwal, Monica Aggarwal, Lydia Alexander, Caroline M. Apovian, Shagun Bindlish, Jonathan Bonnet, W. Scott Butsch, Sandra Christensen, Eugenia Gianos, Mahima Gulati, Alka Gupta, Debbie Horn, Ryan M. Kane, Jasdeep Saluja, Deepa Sannidhi, Fatima Cody Stanford, Emily A. Callahan   +17 more
wiley   +1 more source

Reducing Surgery for Pediatric Posttonsillectomy Hemorrhage Using Tranexamic Acid: A Quality Improvement Initiative

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Evaluate the use of tranexamic acid (TXA) and observation as a management option for pediatric patients presenting with posttonsillectomy hemorrhage (PTH). Study Design Retrospective analysis of a prospectively implemented quality improvement initiative with a historical control comparison group. Setting Tertiary children's hospital.
Laura A. Petrauskas, Janavi Sethurathnam, Ansley J. Kunnath, Rahul K. Sharma, John Ceremsak, Ryan H. Belcher, James D. Phillips, Jay A. Werkhaven, Amy S. Whigham, Lyndy J. Wilcox, Christopher T. Wootten, Frank W. Virgin, Jason S. Park   +12 more
wiley   +1 more source

Effect of creatine monohydrate on motor function in children with facioscapulohumeral muscular dystrophy: A multicenter, randomized, double‐blind placebo‐controlled crossover trial

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Background Facioscapulohumeral muscular dystrophy (FSHD) is a rare, progressive muscle disease with no available disease‐modifying therapy. Creatine monohydrate (CrM) has been shown to improve muscle strength in individuals with muscular dystrophies but has not been tested in young people with FSHD.
Ian R. Woodcock, Katy de Valle, Anita Cairns, Zoe E. Davidson, Michael Kean, Nisha Varma, Anneke Grobler, David Metz, Kate Carroll, Nuran Dilek, Chad Heatwole, Monique M. Ryan, Martin B. Delatycki, Eppie M. Yiu   +13 more
wiley   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

Aspirin delays preterm birth in pregnancies at high risk for preterm pre‐eclampsia: evidence from randomized clinical trial in Asia

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objectives To investigate the impact of aspirin administration on the incidence of preterm birth, according to the type of delivery and gestational age at preterm birth, and to examine the hypothesis that aspirin delays preterm delivery. Methods This was a secondary analysis of a multicenter stepped‐wedge cluster randomized trial of a first ...
H. H. Y. Leung, I. Papastefanou, Y. Chen, L. Nguyen‐Hoang, D.‐A. Nguyen, L. T. Dinh, R. K. Pooh, A. Shiozaki, M. Zheng, Y. Hu, Y. Wu, A. Kusuma, P. Yapan, A. Gosavi, A. Sekizawa, S. Luewan, T.‐Y. Chang, N. Chaiyasit, T. Nanthakomon, H. Liu, S. W. Shaw, W. C. Leung, A. S. Mohamad, A. Aguilar, S. L. Lau, N. M. W. Lee, J. Lin, D. S. Sahota, M. K. C. Chong, L. C. Poon   +29 more
wiley   +1 more source

The WISE Room: An innovative multisensory space for self‐regulation and immersive support for neurodivergent students

British Journal of Special Education, EarlyView.
Abstract The evolving landscape of higher education necessitates a nuanced approach to accommodating the diverse needs of neurodivergent students, including those identifying as having autism, dyslexia, dyspraxia, attention deficit hyperactivity disorder, dyscalculia or Tourette's syndrome.
Tor Alexander Bruce, Eve Champney‐Smith, Satu Eleftheropoulou, Tom Nicholson, Mark Lambert, Barry Hill   +5 more
wiley   +1 more source