Results 61 to 70 of about 2,340,035 (348)

Hypersensitivity reaction to hyaluronic acid dermal filler after the Pfizer vaccination against SARS-CoV-2

International Journal of Infectious Diseases, 2021
The ongoing vaccination program in the control of novel coronavirus (COVID-19)is providing an opportunity to public health authorities to emerge from the current pandemic crisis.Covid vaccination which protects from getting Covid  may have some minor ...
Demetris Savva, Gopi Battineni, Francesco Amenta, Giulio Nittari   +3 more
doaj   +1 more source

A dominant repressor version of the tomatoSl-ERF.B3gene confers ethylene hypersensitivity via feedback regulation of ethylene signaling and response components [PDF]

, 2013
Ethylene Response Factors (ERFs) are downstream components of the ethylene signal transduction pathway, although their role in ethylene-dependent developmental processes remains poorly understood. As the ethylene-inducible tomato Sl-ERF.B3 has been shown
Achard, Allen, Alonso, Benavente, Berrocal-Lobo, Bleecker, Brown, Chakravarthy, Chao, Dubois, Fujimoto, Gu, Gu, Hall, Hao, Heyl, Hiratsu, Hua, Johnson, Ju, Kevany, Kevany, Kieber, Leclercq, Lee, Li, Lin, Magome, Matsui, Matsui, McGrath, Mitsuda, Nakano, Ohme-Takagi, Oñate-Sánchez, Pan, Pirrello, Pirrello, Pré, Riechmann, Sasaki, Solano, Solano, Tieman, Tieman, Tournier, Trujillo, van der Fits, Wang, Wuriyanghan, Yokotani, Zhang   +51 more
core   +4 more sources

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Tolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation [PDF]

, 2014
Autoimmune diseases are driven by immune cells that recognize self-tissues. A major goal for treatment strategies for autoimmune diseases is to turn off or tolerize self-reactive immune cells such as CD4 T cells that coordinate tissue damage in many ...
A. David, Ahmed, Araki, Bauer, Black, Bour-Jordan, Chappert, Crawford, Endres, F. Crawford, Ferraro, Getts, Hasselberg, Higgins, Huster, J. W. Kappler, Kearney, Leech, London, Lumsden, M. MacLeod, Macleod, McAleer, McKinstry, Ndejembi, Nepom, O'neill, Okkenhaug, P. Garside, P. Marrack, Prakken, Raychaudhuri, Sabatos-Peyton, Song, Valujskikh, Verbeek, Walsh, Wilkinson, Zhai   +38 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Molecular-neurovascular mechanisms of metal implant hypersensitivity as a cause of osteosynthesis failure and delayed bone union: a clinical case study

Medičnì Perspektivi
Metal hypersensitivity is a rare but clinically significant cause of aseptic inflammation and delayed bone union after osteosynthesis. The release of nickel, cobalt, and chromium ions from metal implants induces a T-lymphocyte–mediated delayed-type ...
Ya.D. Bondarenko, M.Yu. Stroiev, M.I. Lytvynenko, M.D. Bitchuk   +3 more
doaj   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Profile of sugammadex for reversal of neuromuscular blockade in the elderly: Current perspectives [PDF]

, 2017
The number of elderly patients is increasing worldwide. This will have a significant impact on the practice of anesthesia in future decades. Anesthesiologists must provide care for an increasing number of elderly patients, who have an elevated risk of ...
Bertoncello, Francesco, Carron, Michele, Ieppariello, Giovanna   +2 more
core   +1 more source

Diminished Signal‐to‐Noise Ratio Disrupts Somatosensory Population Encoding and Drives Tactile Hyposensitivity in the Fmr1−/y Autism Model

Advanced Science, EarlyView.
This study provides a translational approach for linking neural activity to tactile deficits in autism. By combining psychophysics with cortical recordings in a mouse model of autism, we show that low signal‐to‐noise ratio in somatosensory neurons weakens population encoding of fine touch, impairing detection, decoding, and leading to perceptual ...
Ourania Semelidou, Théo Gauvrit, Célien Vandromme, Alexandre Cornier, Anna Saint‐Jean, Yves Le Feuvre, Melanie Ginger, Andreas Frick   +7 more
wiley   +1 more source

Hypersensitivity reactions to therapeutic monoclonal antibodies: Phenotypes and endotypes

Journal of Allergy and Clinical Immunology, 2018
Background: The increasing use of mAbs has led to a rise in hypersensitivity reactions (HSRs), which prevent their use as first‐line therapy. HSRs' symptoms, diagnostic tools, and directed management approaches have not been standardized.
G. Isabwe, Marlene Garcia Neuer, Leticia de las Vecillas Sánchez, D. Lynch, Kathleen A. Marquis, M. Castells   +5 more
semanticscholar   +1 more source