Results 81 to 90 of about 630,671 (289)

Suspected Dorzolamide–Induced Delayed Hypersensitivity Blepharitis in Dogs

Acta Veterinaria
The aim was to investigate the incidence, clinical presentation, and potential risk factors for suspected dorzolamide-induced blepharitis (DIB), in dogs diagnosed with glaucoma or hereditary glaucoma predisposition.
Grozdanić Sinisa, Luzhetskii Sergei, Lazić Tatjana, Milčić-Matić Natalija   +3 more
doaj   +1 more source

The impact of medication shortages on paediatric care: A retrospective impact analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Medication shortages are a growing global concern, with potentially greater consequences in paediatric patients because of the limited availability of safe, evidence‐based and appropriately formulated medication. This study aimed to evaluate the impact of medication shortages on paediatric patients by assessing the suitability and safety of ...
Maaike Johanna Rutten ‐ van Kranenburg, Laurens Christiaan van Rijn, Elisabeth Johanna Ruijgrok, Sinno Henricus Paulus Simons, Brigitta Carolina Maria Witjes, Jan‐Dietert Christoffer Brugma, Robert Bernard Flint   +6 more
wiley   +1 more source

Next-Generation Sequencing and Genotype Association Studies Reveal the Association of HLA-DRB3*02:02 With Delayed Hypersensitivity to Penicillins

, 2021
Background: Nonimmediate (delayed) allergic reactions to penicillins are common and some of them can be life-threatening. The genetic factors influencing these reactions are unknown/poorly known/poorly understood.
Mayorga, Cristobalina, Torres, María José, Romano, Antonino, Guéant, Jean, Louis, Cornejo-García, José Antonio, Oussalah, Abderrahim, Chery, Céline, Rouyer, Pierre, Josse, Thomas, Guéant-Rodriguez, Rosa-Maria, Gaeta, Francesco   +10 more
core   +1 more source

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

The potential impact of H1 antihistamines on clinical outcomes in NSCLC patients undergoing EGFR‐TKIs treatment

British Journal of Clinical Pharmacology, EarlyView.
Background Epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR‐TKIs) have substantially improved outcomes in non‐small cell lung cancer (NSCLC); however, the development of treatment resistance remains a major clinical challenge. This study examines the association between concomitant prescriptions of H1‐antihistamines (H1AHs) and ...
Van Thuan Nguyen, Ngoc Hoang Le, Nhu Quynh Phan, Toan Trung Duong, Le Thi Anh Thu, Hsuan‐Chia Yang, Chih‐Wei Huang, Min‐Huei Hsu, Jason C. Hsu, Chien‐Tien Su, Phung‐Anh Nguyen   +10 more
wiley   +1 more source

Delayed hypersensitivity reactions to diclofenac

Allergy, 2003
Allergy
Klingenberg, R. D., Bassukas, I. D., Homann, N., Stange, E. F., Ludwig, D.   +4 more
openaire   +3 more sources

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source

Cystic fibrosis: desensitization in delayed hypersensitivity reactions to elexacaftor/tezacaftor/ivacaftor

Frontiers in Pharmacology
Background: Cystic fibrosis transmembrane conductance regulator modulators are the only available treatment for cystic fibrosis. Although elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is well-tolerated, rash has been reported as very frequent. In severe
L. Gómez-Ganda, P. Galván-Blasco, P. Galván-Blasco, A. Fernández-Polo, V. Cardona, V. Cardona, B. García-Palop, CJ Parramón-Teixidó, E. Polverino, A. Álvarez-Fernández   +9 more
doaj   +1 more source

Study of immunomodulatory activity of aqueous extract of Carica papaya in Wistar rats

National Journal of Physiology, Pharmacy and Pharmacology, 2016
Background: Various parts of Carica papaya (CP) Linn. have been traditionally used as ethnomedicine for a number of disorders including cancer. There have been anecdotes of patients with advanced cancers achieving remission following consumption of tea ...
K. S. Ramesh, Ravindranath S. Kambimath, N. Venkatesan   +2 more
doaj   +1 more source