Results 161 to 170 of about 54,107 (304)

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Hypersensitivity reactions to trimetrexate

, 2007
Trimetrexate is a nonclassical antifol currently being tested for efficacy in cancer patients and as an antiparasitic agent against Pneumocystis carinii pneumonia in AIDS patients.
Grem, J. L., King, S. A., Costanza, Mary E., Brown, T. D.   +3 more
core  

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Tolerance induction for EGFR TKI hypersensitivity in lung cancer: Case report and review. [PDF]

J Allergy Clin Immunol Glob
Haraguchi Hashiguchi M, Adachi T, Asaoka M, Ito T, Kaburagi S, Kagyo J, Okata-Karigane U, Takahashi C, Tahara U, Yoneda S, Masaki K, Fukunaga K.   +11 more
europepmc   +1 more source

Experiencing and Responding to Existential Vulnerability: Navigating the Work–Fertility Treatment Interface

Gender, Work &Organization, EarlyView.
ABSTRACT The need to undergo fertility treatment to fulfill parenthood aspirations involves many challenges in professional and personal domains. Extant scholarship has tended to focus on the identity threats and individual experiences of the challenges involved, but research has not delved into the more relational experiences that may characterize ...
Céire Gilsenan, Yseult Freeney, Lisa van der Werff, Hilary O'Leary   +3 more
wiley   +1 more source

Macrolide-induced hypersensitivity reactions in the pediatric population. [PDF]

Ital J Pediatr
Caimmi S, Liotti L, Riscassi S, Rosset G, Bottau P, Bianchi A, Crisafulli G, Franceschini F, Mori F, Saretta F, Valluzzi RL, Buono EV, Marseglia GL, Caffarelli C.   +13 more
europepmc   +1 more source

Defining the Role of Nurses in Gene Therapy for Haemophilia

Haemophilia, EarlyView.
Abstract Introduction Haemophilia is a rare bleeding disorder now undergoing a major shift in care as gene therapy (GT), delivered through viral‑vector in vivo gene transfer, has enabled adults with haemophilia A or B to stop prophylaxis with minimal bleeding.
Greta Mulders, Simon Fletcher, Aysen Tasgin, Marica Moro, Marléne Beijlevelt, Kate Khair   +5 more
wiley   +1 more source

Immediate allergy against glucagon-like peptide-1 receptor agonist liraglutide. [PDF]

Asia Pac Allergy
Özdemir Ö.
europepmc   +1 more source

Severe Hair Dye Anaphylaxis Caused by Toluene‐2,5‐ Diamine Identified by Positive in Vitro Tests

Contact Dermatitis, EarlyView.
Eglė Janušonytė, Thomas Harr, Pierre Piletta, Sophie Vandenberghe‐Dürr   +3 more
wiley   +1 more source

The pharmacology of gepants in migraine: A scoping review on mechanisms, clinical applications, and combination strategies

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Background Calcitonin gene‐related peptide (CGRP) is a key mediator in migraine pathophysiology, and the development of gepants, novel CGRP receptor antagonists, has expanded therapeutic options for both acute and preventive treatment. This scoping review aims to synthesize current evidence on the pharmacology, clinical applications, safety ...
Luigi Francesco Iannone, Marcello Silvestro, Antonio Munafò, Marina Romozzi, Pierangelo Geppetti, Antonio Russo   +5 more
wiley   +1 more source