Results 111 to 120 of about 369,698 (260)

A Joint Pharmacometric Model of Iohexol and Creatinine Administered through a Meat Meal to Assess GFR and Renal OCT2/MATE Activity

Clinical Pharmacology &Therapeutics, EarlyView.
Accurately assessing glomerular filtration rate (GFR) from plasma creatinine concentrations is challenging in patients with unstable renal function. This study aimed to refine the understanding of creatinine kinetics for more reliable assessments of GFR and net creatinine tubular secretion (nCTS) via OCT2/MATE in humans.
Zhendong Chen, Qian Dong, Charalambos Dokos, Jana Boland, Uwe Fuhr, Max Taubert   +5 more
wiley   +1 more source

Astrocytic Inducible Nitric Oxide Synthase Upregulation Contributes to Chronic Below-Level Neuropathic Pain Following Spinal Cord Injury in Male Rats. [PDF]

Eur J Pain
Kim Y, Kang H, Yoon YW.
europepmc   +1 more source

Confirmation of Fixed Quarterly Riliprubart Regimen in Patients with Cold Agglutinin Disease Using Population PK/PD and Exposure‐Response Analyses

Clinical Pharmacology &Therapeutics, EarlyView.
Riliprubart is a second‐generation, humanized immunoglobulin G4 that inhibits only the activated form of the C1s component of the proximal classical complement pathway. The clinical studies of riliprubart conducted thus far for the treatment of cold agglutinin disease (CAD), a rare autoimmune disease, include a Phase 1 first‐in‐human study in healthy ...
Timothy Chow, Marek Wardecki, Michael Storek, Nancy Wong   +3 more
wiley   +1 more source

Fibroblast reprogramming in the dura mater of NTG-induced migraine-related chronic hypersensitivity model drives monocyte infiltration via Angptl1-dependent stromal signaling. [PDF]

J Headache Pain
Guo G, Zhang L, Liu X, Deng Y, Wu P, Zhao R, Wang W.   +6 more
europepmc   +1 more source

Hypersensitivity to romidepsin

Journal of the American Academy of Dermatology, 2014
Jenneé Rommel, Jennifer A. DeSimone, Aarthi Shenoy, Rohit Kakar, Lynn McKinley-Grant   +4 more
openaire   +2 more sources

Use of PopPK and E‐R Analyses toward Explaining Causal Link Between ADAMTS13 in Recombinant vs. Plasma‐Based Therapies and Clinical Effects in cTTP

Clinical Pharmacology &Therapeutics, EarlyView.
Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra‐rare, potentially life‐threatening condition caused by a deficiency of the blood enzyme ADAMTS13. Until now, ADAMTS13 replacement has been achieved with infusions of plasma or plasma‐based therapies (PBT).
Munjal Patel, Huijuan Xu, Olivier Barriere, Paul Diderichsen, Parth Patwari, Andy Z. X. Zhu, Jean François Marier, Thomas Peyret, Linda T. Wang, Björn Mellgård, Wenping Wang, Indranil Bhattacharya   +11 more
wiley   +1 more source

Fluconazole-induced drug rash with eosinophilia and systemic symptoms syndrome: a case report. [PDF]

J Med Case Rep
Kim S, Chen K, Stull W.
europepmc   +1 more source

Synthesis of 19‐Hydroxyarachidonic Acid by Fungal Peroxygenases: An Experimental and Computational Study

ChemSusChem, Accepted Article.
Hydroxylated derivatives of arachidonic acid play crucial roles in physiology and inflammation response, with distinct biological effects for (R)‐ and (S)‐enantiomers, highlighting their pharmaceutical relevance. Here, we harness recombinant unspecific peroxygenases (UPOs)—from the fungi Coprinopsis cinerea (rCciUPO) and Agrocybe aegerita (rAaeUPO ...
Alejandro González-Benjumea, Mireia Martínez-Sugrañes, Miguel Alcalde, Elvira Romero, Víctor Guallar, Martin Floor, Angel T. Martínez, Ana Gutiérrez   +7 more
wiley   +1 more source

Validation of an 8-item self-administered questionnaire for assessing migraine-related sensory hypersensitivities (MHQ-8). [PDF]

J Headache Pain
Gabrielli F, Zuel M, Magaud C, Sickout-Arondo S, Pereira B, Dassa J, De Gaalon S, Demarquay G, Donnet A, Ducros A, Giraud P, Guégan-Massardier E, Lucas C, Mawet J, Najjar M, Roos C, Van Obberghen EK, Dualé C, Dallel R, Moisset X.   +19 more
europepmc   +1 more source

A one‐year efficacy assessment of subcutaneous immunotherapy in dust mite allergic rhinitis patients based on clinical symptoms and objective biomarkers

Eye &ENT Research, EarlyView.
Abstract Objective To evaluate the 1‐year efficacy of subcutaneous immunotherapy (SCIT) in treating dust mite‐induced allergic rhinitis (AR) and establish objective biomarkers for efficacy monitoring. Methods Fifty‐nine AR patients underwent 1‐year SCIT. Subjective symptoms were assessed via total nasal symptom score (TNSS), combined symptom/medication
Jingwen Wang, Xu Xu, Xu Zhang, Yuan Zhang, Jingyun Li   +4 more
wiley   +1 more source