Results 111 to 120 of about 371,617 (308)

Unveiling the Complete Biosynthetic Pathway of Azacitidine: A Rare 1,3,5‐Triazine Nucleoside Derived From GTP

Angewandte Chemie, EarlyView.
The azacitidine biosynthetic gene cluster (aza BGC) was identified by the resistance‐gene‐guided comparative genomics method in Streptomyces mobaraensis IPIO2. The complete biosynthetic pathway of azacitidine, which follows a “base‐first‐then‐glycosylation” logic, was elucidated through in vivo and in vitro experiments.
Dan Wang, Qingxu Meng, Lingqi Hua, Mengjun Sun, Qianjin Kang, Min‐Juan Xu, Linquan Bai   +6 more
wiley   +2 more sources

Hypersensitivity reactions grading standard.

, 2014
Hypersensitivity reactions grading standard.
Guangyao Lv (674770), Pengkai Ma (674772), Guangying Du (674773), Jinbo Ma (674771), Zongliang Wang (674774), Jianqiao Zhang (674769), Hongbo Wang (587749), Jingwei Tian (587745), Weishuo Fang (674775), Fenghua Fu (587750)   +9 more
core   +1 more source

Temporally Correlated Stochastic Spiking Neural Networks Enabled by 2D Ferroelectric Synapse‐Neuron Integration

Advanced Science, EarlyView.
We demonstrate a stochastic spiking neural network by integrating an α‐ln2Se3/h‐BN/CIPS FeFET synapse with an Au/CIPS/Au neuron. Unlike conventional memoryless stochastic neurons, the proposed neuron generates stochastic spikes through the evolution of internal ferroelectric polarization states, giving rise to intrinsic temporal correlations and ...
Hanseo Jeon, Ui Do Ji, Sangmin Lee, Gihyeon Bhin, Chang Yong Park, Ji‐Sang Park, Byungchul Jang, Sungjoo Lee   +7 more
wiley   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Classification of hypersensitivity reactions.

, 2013
Classification of hypersensitivity reactions.
Simon G. A. Brown (131283), Chandana Abeysinghe (157347), Geoffrey K. Isbister (131304), Harendra Karunathilake (157352), Claire L. Cotterell (437221), Shelley F. Stone (356793), Ariaranee Ariaratnam (157358), Fahim Mohamed (157341), Seyed Shahmy (157335), Tamara E. Jacoby-Alner (437220)   +9 more
core   +1 more source

Molecularly Engineered Nitrate Double Perovskites with Elevated Ferroelectric Phase Transition Temperature and Large Piezoelectric Response

Advanced Science, EarlyView.
This study reports molecularly engineered nitrate double perovskites based on systematic BI‐site cation substitution. This molecular engineering modulates local BI···NO3 interactions, nitrate connectivity, and collective physical responses, accompanied by structural conversion from mixed corner‐/face‐sharing structures to three‐dimensional corner ...
Le Ye, Guang‐Yuan Hu, Yarou Duan, Yutong Lin, Ding‐Chong Han, Zi‐Luo Fang, Zhe Dong, Wei‐Xiong Zhang, Liang‐Han Shen, Na Wang, Le‐Ping Miao, Heng‐Yun Ye, Lingling Mao   +12 more
wiley   +1 more source

A DNA G‐Quadruplex‐Targeting Ligand Suppresses c‐MYC Expression: Implications for Gemcitabine‑Resistant Pancreatic Cancer

Angewandte Chemie, EarlyView.
PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng, Ya‐Kun Wang, Ze‐Xin Chen, Yi‐Wen Meng, Meng‐Ting She, Jia‐Peng Dong, Yingying Zheng, Yao‐Xun Zeng, Wen‐De Zheng, Wei Long, Wing‐Leung Wong   +10 more
wiley   +2 more sources

THE FACTS ABOUT PENICILLIN ALLERGY: A REVIEW

Journal of Advanced Pharmaceutical Technology & Research, 2010
Hypersensitivity reactions are the major problem in the use of penicillins. Truepenicillin allergy is rare with the estimated frequency of anaphylaxis at 1-5 per 10 000cases of penicillin therapy.
Sanjib Bhattacharya
doaj  

Cross‐Organ Multi‐Omics Profiling of Systemic Alterations in 5xFAD Mice and Changes Associated with Huanglian Jiedu Decoction Treatment

Advanced Science, EarlyView.
Cross‐organ multi‐omics reveals coordinated inflammatory and metabolic disturbances in 5xFAD mice. Huanglian Jiedu Decoction improves cognition and alleviates brain and liver abnormalities. Complementary hepatocyte–microglia conditioned‐medium experiments suggest PPAR‐γ involvement in treatment‐associated changes in microglial inflammation, providing ...
Wenya Gao, Jing Gao, Xiaohui Su, Xiangying Kong, Xiaolu Wei, Tunan Ding, Tiantian Guo, Shuangrong Gao, Yanyan Zhou, Junyi Zhou, Haiyu Zhao   +10 more
wiley   +1 more source

Dentine hypersensitivity: an update [PDF]

Dentine hypersensitivity (DH) appears to be increasing in prevalence over time, both in the UK and across the world. As many of our patients are living longer and retaining their natural dentition later into life, dentine hypersensitivity may become a ...
Gillam, David, Rose, Charlie, Olley, Ryan   +2 more
core   +1 more source