Results 141 to 150 of about 358,537 (259)

Electroacupuncture at ST36 Alleviates Visceral Hypersensitivity and Anxiety via ACC-AIC Circuit Modulation in IBS Rats [PDF]

Dan Wang,1 Yixuan Guo,2 Zhichun Wu,3 Haiyan Zhang4 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250355, People’s Republic of China; 2College of Acupuncture-Moxibustion and Tuina, Shandong
Wu Z, Guo Y, Wang D, Zhang H
core  

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Editorial: Drug Hypersensitivity: From Mechanisms to Improved Diagnosis and Standards of Care

Frontiers in Pharmacology, 2021
T. D. Fernandez, T. D. Fernandez, M. J. Torres, M. J. Torres, M. J. Torres, M. J. Torres, A. Romano, A. Romano   +7 more
doaj   +1 more source

Dentin Hypersensitivity and Treatment of Dentin Hypersensitivity

, 2012
Tooth hypersensitivity is very common clinical presentation. Dentin hypersensitivity is characterized by a short, sharp pain arising from exposed dentin, typically in response to thermal, chemical, tactile or osmotic stimuli. Treatment for hypersensitive
Sezgin, Benin, TARIM, Berna
core  

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Successful Rapid Desensitization to Ceftazidime/Avibactam in a Patient With Cystic Fibrosis and Multidrug-Resistant <i>Pseudomonas aeruginosa</i> Pneumonia: A Case Report. [PDF]

Clin Case Rep
Zhou Z, Zhu J, Wu G, Kang X, Wang Q, Liu J, Jiang Y.   +6 more
europepmc   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Hypersensitivity Reaction to Tirzepatide With Demonstrated Tolerance to Semaglutide: A Case Report. [PDF]

Clin Case Rep
Nejat C, Lin R, Addo D, Cuenca-Sisko K, Lee-Wong M.   +4 more
europepmc   +1 more source

Evaluating a virtual paediatric adverse drug reaction clinic

British Journal of Clinical Pharmacology, EarlyView.
Aims Adverse drug reactions (ADRs) are a common problem in paediatric health care. There is limited access to expertise in the evaluation and management of potential ADRs in children, limiting access to these services and creating delays in assessment and management.
Emily Hauck, Blanca Del Pozzo‐Magana, Michael Rieder   +2 more
wiley   +1 more source