Results 151 to 160 of about 371,617 (308)

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Evaluating a virtual paediatric adverse drug reaction clinic

British Journal of Clinical Pharmacology, EarlyView.
Aims Adverse drug reactions (ADRs) are a common problem in paediatric health care. There is limited access to expertise in the evaluation and management of potential ADRs in children, limiting access to these services and creating delays in assessment and management.
Emily Hauck, Blanca Del Pozzo‐Magana, Michael Rieder   +2 more
wiley   +1 more source

Editorial: Drug Hypersensitivity: From Mechanisms to Improved Diagnosis and Standards of Care

Frontiers in Pharmacology, 2021
T. D. Fernandez, T. D. Fernandez, M. J. Torres, M. J. Torres, M. J. Torres, M. J. Torres, A. Romano, A. Romano   +7 more
doaj   +1 more source

Metal Hypersensitivity Reactions Following Spinal Implants: A Systematic Review. [PDF]

JBJS Rev
Abbo J, Thomas J, Stipho C, Nakken E, Patel R, Piche JD, Aleem I.   +6 more
europepmc   +1 more source

HLA‐B*15:21 carrier status is a susceptibility factor of carbamazepine‐induced nonimmediate cutaneous adverse reactions in HLA‐B*15:02‐negative patients: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
After HLA‐B*15:02 screening, the residual risk of carbamazepine‐induced nonimmediate cutaneous adverse reactions is 0.059. Among these HLA‐B*15:02‐negative cases, HLA‐B*15:11 and HLA‐B*15:21 carrier status significantly increases the risk of carbamazepine‐induced nonimmediate cADR.
Warit Ruanglertboon, Chutima Seree‐aphinan, Antida Sangiemchoey, Khwanchanok Kaewpiboon, Taweesak Maneerot, Oradawan Plong‐on, Pornsiri Sangmanee, Punthipa Nichanon, Jariya Khayman, Jiraphan Manee, Areerat Hnoonual, Kanoot Jaruthamsophon   +11 more
wiley   +1 more source

Titanium Hypersensitivity as a Potential Contributor to Bronchopleural Fistula and Surgical Staple Extrusion Following Lung Cancer Surgery: A Case Report. [PDF]

Case Rep Pulmonol
Lucena M, Regalo S, Manso Preto L, Todo Bom A, Regateiro F.   +4 more
europepmc   +1 more source

The impact of medication shortages on paediatric care: A retrospective impact analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Medication shortages are a growing global concern, with potentially greater consequences in paediatric patients because of the limited availability of safe, evidence‐based and appropriately formulated medication. This study aimed to evaluate the impact of medication shortages on paediatric patients by assessing the suitability and safety of ...
Maaike Johanna Rutten ‐ van Kranenburg, Laurens Christiaan van Rijn, Elisabeth Johanna Ruijgrok, Sinno Henricus Paulus Simons, Brigitta Carolina Maria Witjes, Jan‐Dietert Christoffer Brugma, Robert Bernard Flint   +6 more
wiley   +1 more source

Orthopedic implant allergies: a review of current knowledge on metal hypersensitivity and prosthesis failure. [PDF]

EFORT Open Rev
Viola V, Marelli N, Caplanusi T, Steinmetz S.   +3 more
europepmc   +1 more source

Dentin Hypersensitivity and Treatment of Dentin Hypersensitivity

, 2012
Tooth hypersensitivity is very common clinical presentation. Dentin hypersensitivity is characterized by a short, sharp pain arising from exposed dentin, typically in response to thermal, chemical, tactile or osmotic stimuli. Treatment for hypersensitive
Sezgin, Benin, TARIM, Berna
core  

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source