Results 191 to 200 of about 521,930 (421)

Hypersensitivity Pneumonitis: A Comprehensive Review [PDF]

open access: yes, 2017
none8siHypersensitivity pneumonitis (HP), also known as extrinsic allergic alveolitis, is a complex pulmonary syndrome mediated by the immune system and caused by inhalation of a wide variety of antigens to which the individual has been previously ...

core  

Application of humanized mice in the safety experiments of antibody drugs

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun   +9 more
wiley   +1 more source

THE FACTS ABOUT PENICILLIN ALLERGY: A REVIEW

open access: yesJournal of Advanced Pharmaceutical Technology & Research, 2010
Hypersensitivity reactions are the major problem in the use of penicillins. Truepenicillin allergy is rare with the estimated frequency of anaphylaxis at 1-5 per 10 000cases of penicillin therapy.
Sanjib Bhattacharya
doaj  

Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers

open access: yesAdvanced NanoBiomed Research, EarlyView.
Lanthanide‐based luminescence nanothermometry holds multifaceted potential for nanomedical applications, yet despite significant research advances, clinical translation of the engineered nanomaterials is still controversial and widely disputed. This is related to crucial nanotoxicological aspects that must be addressed at the preclinical level ...
Simona Premcheska   +2 more
wiley   +1 more source

Pain‐autonomic measures reveal nociceptive sensitization in complex regional pain syndrome

open access: yesEuropean Journal of Pain, Volume 27, Issue 1, Page 72-85, January 2023., 2023
Abstract Background Allodynia and hyperalgesia are common signs in individuals with complex regional pain syndrome (CRPS), mainly attributed to sensitization of the nociceptive system. Appropriate diagnostic tools for the objective assessment of such hypersensitivities are still lacking, which are essential for the development of mechanism‐based ...
Paulina S. Scheuren   +5 more
wiley   +1 more source

Outcome of Patients With Lupus Nephritis Treated With an Anti‐CD40 Monoclonal Antibody According to Kidney Biopsy Features

open access: yesArthritis &Rheumatology, EarlyView.
Objective A phase 2 trial tested different doses of the anti‐CD40 monoclonal antibody BI 655064 as an add‐on therapy to the standard of care in patients with class III or IV lupus nephritis (LN) with active disease. A post hoc analysis showed a potential benefit of the higher tested doses (180 and 240 mg) versus a low dose (120 mg) or placebo.
Martina Uzzo   +5 more
wiley   +1 more source

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