Results 201 to 210 of about 358,537 (259)

Operationalizing Precision Medicine in Drug Development: Predictive Biomarkers, Companion Diagnostics, and Regulatory Pathways

Clinical Pharmacology &Therapeutics, EarlyView.
Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg, José M.A. Moreira   +1 more
wiley   +1 more source

Does the teicoplanin skin test predict IgE-mediated hypersensitivity? [PDF]

Allergol Select
Baştuğ İnan NB, Göktürk Ö, Karahan Y, Aksu K.   +3 more
europepmc   +1 more source

Early and High‐Dose Glucocorticoid Use and Survival in Advanced NSCLC Receiving Immune Checkpoint Inhibitors: A Multicenter Target Trial Emulation

Clinical Pharmacology &Therapeutics, EarlyView.
Despite the immunomodulatory mechanism of immune checkpoint inhibitors (ICIs), systemic glucocorticoids are commonly used in advanced non–small cell lung cancer (NSCLC). Evidence regarding their effects on ICI outcomes is inconsistent, in part due to confounding by indication and immortal time bias.
Da Eun Lee, Geunho Lim, Minoh Ko, Mari Kim, Ji Sun Chun, Borim Lee, Miso Kim, Kwangsoo Kim, Byung Kwan Choi, Jeongmin Seo, Jin Hyoung Kang, Taehoon Ko, In‐Wha Kim, Jung Mi Oh   +13 more
wiley   +1 more source

Isolated Allergic Conjunctivitis Induced by an Oral Nonsteroidal Anti-inflammatory Drug (NSAID), Confirmed by an Oral Provocation Test: A Case Report. [PDF]

Cureus
Hidan Y, Chafi J.
europepmc   +1 more source

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source

Comparative Assessment of Ibuprofen-Arginine and Potassium Nitrate-Fluoride Gels for Reducing Post-Bleaching Dentin Sensitivity: A Randomized, Double-Blind, Split-Mouth Trial. [PDF]

Int J Dent
Colognese MRV, Kayser LA, Dalagustinho SKS, Cardoso PMF, Camilotti V.   +4 more
europepmc   +1 more source

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

Developmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm, Daniel Dogeon Lee, Zhongqiang Qiu, Angela Haeun Choi, Meghana Kolluri, Michael J. Olsen, Lianzijun Wang, Myeongwoo Lee   +7 more
wiley   +1 more source

HLA allele profiling and association in Thai patients with confirmed beta-lactam hypersensitivity: an NGS-based analysis. [PDF]

Front Pharmacol
Lumkul L, Kulalert P, Sompornrattanaphan M, Krikeerati T, Suvichapanich S, Thongkumkoon P, Noisagul P, Wongsa C, Thongngarm T, Laisuan W, Pruksakorn D, Pongcharoen P, Nanthapisal S, Lertnawapan R, Phinyo P.   +14 more
europepmc   +1 more source

Switchable Dual Emission of Luminescent Metal–Organic Framework@Nanoparticle Composites of EuBDC and ZrO‐Containing Hybrid Materials

European Journal of Inorganic Chemistry, EarlyView.
Luminescent metal–organic framework@nanoparticle composites show dual emission of both components EuBDC and zirconyl‐containing nanoparticles, being reversible, excitation energy‐dependent and solvatochromic switches. The chromaticity changes are fast, as no chemical transformation is involved and required as source of the dual emission.
Tobias Wehner, Joachim G. Heck, Claus Feldmann, Klaus Müller‐Buschbaum   +3 more
wiley   +1 more source