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Immunopathogenesis of hypersensitivity pneumonitis
Journal of Allergy and Clinical Immunology, 1977This review describes antigenic and host factors of possible significance in the immunopathogenesis of hypersensitivity pneumonitis (HP). Although certain immunologic studies suggest immune complex mechanisms in HP, recent experimental and clinical data accumulated support a role for cell-mediated immunity.
M, Schatz, R, Patterson, J, Fink
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Mediators of hypersensitivity pneumonitis
Journal of Laboratory and Clinical Medicine, 2000Inhalation of Saccharopolyspora rectivirgula (S. rectivirgula) causes farmer's lung disease, a classic example of hypersensitivity pneumonitis (HP). HP is characterized by bronchoalveolar lavage fluid (BALF) neutrophilia (within the first 48 hours after inhalation), followed by BALF lymphocytosis.
M, Schuyler, K, Gott, A, Cherne
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Pathology of hypersensitivity pneumonitis
Current Opinion in Pulmonary Medicine, 2008Hypersensitity pneumonitis, caused by inhalation of various antigens, is characterized by interstitial mononuclear cell infiltration, nonnecrotizing granulomas, cellular bronchiolitis, and fibrosis. The pathological picture of chronic hypersensitivity pneumonitis is, however, complicated; it is sometimes difficult to differentiate chronic ...
Tamiko, Takemura +4 more
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Bleomycin Hypersensitivity Pneumonitis
Annals of Internal Medicine, 1978Three patients developed radiologic and functional pulmonary changes after bleomycin therapy similar to ones previously associated with administration of this drug. However, biopsy specimens showed a pattern consistent with hypersensitivity pneumonitis rather than the interstitial pneumonia usually reported in bleomycin pulmonary toxicity.
P Y, Holoye +3 more
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The alveolitis of hypersensitivity pneumonitis
European Respiratory Journal, 1988In the pathogenesis of hypersensitivity pneumonitis (HP) several immune mechanisms are involved. The initial phase, 4-48 h after antigen inhalation, appears to be immune complex mediated and is characterized by an early increase in bronchoalveolar lavage (BAL) neutrophils and the histopathologic features of oedema, neutrophil infiltration of the ...
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Hypersensitivity pneumonitis in a machinist
American Journal of Industrial Medicine, 1998Hypersensitivity pneumonitis (HP), or extrinsic allergic alveolitis, is a patchy, interstitial lung disease that involves an immunologic reaction of the lung to repeated inhalation of foreign antigens. In this report, we describe a machinist with exposure to metalworking fluids (MWFs) and biopsy-confirmed HP. Return to work, which could be equated with
A, Freeman +4 more
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Pathogenesis of Hypersensitivity Pneumonitis
Chest, 1986These diseases are virtually always characterized by mono nuclear cell alveolar and interstitial pulmonary infiltrates. Furthermore, the lung is the major site of involvement, and there are no granulomatous lesions in other organs such as the liver and lymph nodes, bone and skin, as seen in sarcoidosis.
J E, Salvaggio, R D, deShazo
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Morphology of hypersensitivity pneumonitis
Russian Journal of Archive of PathologyHypersensitivity pneumonitis (HP) is one of the most common interstitial lung diseases, the manifestations of which are diverse, and the diagnosis is complex and requires a multidisciplinary approach. HP is an immunologically determined disease in response to inhaled antigens.
M.V. Samsonova, A.L. Chernyaev
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The Identification of Hypersensitivity Pneumonitis
Hospital Practice, 1995The clinical history may point suspicion at a specific sensitizer. Brief, intermittent exposure produces acute, often reversible disease, frequently misdiagnosed as viral or bacterial pneumonia. Long-term exposure fuels the insidious development of chronic, disabling disease with minimal reversibility.
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