Results 201 to 210 of about 9,287,329 (300)

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

open access: yesBritish Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli   +6 more
wiley   +1 more source

A CECT‐Based 2PI System as a Novel Noninvasive Prognostic Tool for Hepatocellular Carcinoma: A Dual‐Validation Study

open access: yesCancer Science, EarlyView.
Using differential weighting, we developed a 2PI‐based risk stratification system for HCC recurrence. A comprehensive prognostic model incorporating clinical variables and the 2PI score further enhanced postoperative prediction in solitary HCC and showed initial generalizability across SR and RFA cohorts.
Yingzhu Cui   +10 more
wiley   +1 more source

POLA2‐Related Coats Plus Syndrome: Case Presentation and Description of an Emerging Disorder

open access: yesClinical Genetics, EarlyView.
We report an adult male with bilateral retinal vascular disease, hypocellular bone marrow failure, severe gastrointestinal bleeding, and premature hair graying, with telomere lengths near the 10th percentile. Exome sequencing resulted in the diagnosis of POLA2‐related Coats plus syndrome, making him the sixth reported case.
Daniel W. Serber   +7 more
wiley   +1 more source

Challenging Cytologic Diagnosis of Intrahepatic Cholangiocarcinoma Arising in Ductal Plate Malformation

open access: yesCytopathology, EarlyView.
This case describes a rare intrahepatic cholangiocarcinoma arising in a background of ductal plate malformation/Von Meyenburg complex. Predominant sampling of benign ductal proliferations obscured a focal malignant component, highlighting the importance of recognizing subtle cytomorphologic atypia, correlating pathologic findings with imaging, and ...
Jeffrey Z. Lin   +4 more
wiley   +1 more source

Traumatic Dental Injuries as a Potential Predisposing Factor for Invasive Cervical Resorption: A Systematic Review

open access: yesDental Traumatology, EarlyView.
ABSTRACT Invasive cervical resorption is a clinically challenging and often silent form of external root resorption that may remain undetected until substantial structural damage has occurred. Although traumatic dental injuries are repeatedly cited as potential predisposing factors, the strength, consistency, and clinical meaning of this association ...
Thiago Farias Rocha Lima   +5 more
wiley   +1 more source

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