Results 231 to 240 of about 1,479,001 (304)

Model‐Informed Dose Optimization of Anakinra in Preterm Neonates Implications for Safe and Effective Dosing

Clinical Pharmacology &Therapeutics, EarlyView.
Anakinra, an interleukin‐1 receptor antagonist, shows promise for reducing inflammatory complications of premature birth. However, the pharmacokinetics (PK) of anakinra in neonates has not been characterized, limiting evidence‐based dosing. This study aimed to develop a population PK model for anakinra to guide dosing in preterm neonates.
Jia Li, David K. Metz, Elys Green, Gergely Toldi, Robert Galinsky, Megan Clark, Rebecka Atkinson, Ina Rudloff, Josephine C. Owen, Sara K. DiSimone, Samuel C. Forster, Steven X. Cho, Atif Majid, Graeme R. Polglase, Marcel Favilla, Pramod Pharande, Atul Malhotra, Calum T. Roberts, Scott H. Stansfield, Arvind Sehgal, Kenneth Tan, Alistair J. Gunn, Philip J. Berger, Alex Veldman, Rod W. Hunt, Claudia A. Nold‐Petry, Marcel F. Nold, Carl M. J. Kirkpatrick   +27 more
wiley   +1 more source

Targeting hypertension with SGLT2 inhibition: the EU-funded SGLT2 HYPE trial. [PDF]

Eur Heart J
Eitel I, Saraei R, Rawish E.
europepmc   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

Renal Denervation: A Multicenter, Real-World Experience. [PDF]

Cardiol Res
Rao S, Rao KR, Pillai A, Patil A, Kapadiya A, Gopi A, Swaroop G, Ingle H, Parikh K, Mahesh NK, Shah N, Chandra P, Singh RP, Natarajan R, Rao RS, Showkathali R, Sharma SM, Sathe S, Banerjee S, Rajasekhar V, Rao VSP, Kumar V, Reddy YV.   +22 more
europepmc   +1 more source

The role of the sympathetic nervous system in the pathomechanism and the therapy of hypertension [PDF]

, 2014
Légrády Péter
core  

Urogenital Infection Risk Associated With SGLT2 Inhibitors Versus DPP‐4 Inhibitors in Type 2 Diabetes and Chronic Kidney Disease: A Nationwide Target Trial Emulation

Clinical Pharmacology &Therapeutics, EarlyView.
Although sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are recommended for patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD), concerns regarding urogenital infections persist. Therefore, we evaluated the risk of urinary tract infection (UTI) and genital tract infection (GTI) after SGLT2i initiation in this population ...
Young‐Mi Ah, Junsung Nam, Jung Wook Youn, Yun Mi Yu, Soyoung Kang   +4 more
wiley   +1 more source

The Cerebroplacental-Renal Ratio as a Novel Doppler-Based Marker of Adverse Perinatal Outcome in Pregnancy-Induced Hypertension. [PDF]

Medicina (Kaunas)
Kaya Y, Bilirer KK, Batman A, Çiçek B, Yaman İ, Yeniocak AS, Tercan C, Ohanoglu Cetinel K, Kaya DYY, Polat G.   +9 more
europepmc   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Author Correction: Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development

Nature Communications
Yu Yan, Hongbo Liu, Amin Abedini, Xin Sheng, Matthew Palmer, Hongzhe Li, Katalin Susztak   +6 more
doaj   +1 more source