Results 271 to 280 of about 2,704,025 (289)

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

open access: yesAdvanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun   +9 more
wiley   +1 more source

12‐HETE Is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture

open access: yesAdvanced Science, EarlyView.
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li   +13 more
wiley   +1 more source

Controlling Selectivity at the First Hydrogenation Level: Synthesis of 3‐Hydroxyisoindolines by Heterogeneously Silver‐Catalyzed Monohydrogenation of Phthalimides

open access: yesAdvanced Science, EarlyView.
3‐Hydroxylactams are obtained from phthalimides through a heterogeneous catalyzed chemoselective hydrogenation, able to stop the process at the first hydrogenation level. By using a rationally designed [Ag/Al2O3] recyclable solid nanocatalyst, a wide range of cyclic hemiamidals are accesed through a full atom‐economical reaction that preserves (hetero ...
Carles Lluna‐Galán   +2 more
wiley   +1 more source

Healthcare provider and health system leader perspectives on barriers to hypertension care in Malawi: insights from integrated and non-integrated HIV care settings. [PDF]

open access: yesGlob Health Action
Hagstrom C   +9 more
europepmc   +1 more source

Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease

open access: yesAdvanced Science, EarlyView.
Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Aishwarya Prakash, Thomas Iskratsch
wiley   +1 more source

Hypertension prevalence and associated factors among bank workers in Africa, 2024: a systematic review and meta-analysis. [PDF]

open access: yesBMC Public Health
Moloro AH   +7 more
europepmc   +1 more source

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