Results 271 to 280 of about 2,757,661 (328)

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

The cascade of hypertension prevalence, awareness, treatment, and control in urban-poor communities in Accra, Ghana: a population-based household survey. [PDF]

BMC Public Health
Sanuade OA, Baatiema L, Kretchy IA, Okoibhole L, Kushitor SB, Grijalva-Eternod CS, Lule SA, Arhinful D, Koram K, Fottrell E.   +9 more
europepmc   +1 more source

Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines

Advanced Science, EarlyView.
Challenging the focus on age, this study finds pre‐existing T helper 1 cells are the key biomarker for predicting antibody response to SARS‐CoV‐2 inactivated vaccines. In both mice and humans, high responders exhibited elevated baseline T helper 1 cells, which correlated with robust humoral immunity, offering crucial guidance for improving vaccine ...
Chanyuan Ye, Xiaoli Zhang, Lingfeng Qiu, Jia Ji, Jueqing Gu, Hongyu Jia, Yingfeng Lu, Jiyang Chen, Zelu Meng, Jiangshan Lian, Hangping Yao, Xun Zeng, Yida Yang   +12 more
wiley   +1 more source

Nocturnal Stage 1 Hypertension Defined by 2025 Guidelines in Adults With Chronic Kidney Disease.

JAMA Netw Open
Zhang T, Zhou Z, Li Q, Cai X, Lin L, Peng H, Li M, Wang C, Jiang X.   +8 more
europepmc   +1 more source

The Effects of a Health Literacy Promotion Program on Health Behaviors and Blood Pressure Levels Among Uncontrolled Hypertensive Patients: A Quasi-Experimental Study. [PDF]

J Prim Care Community Health
Tesamut L, Sungwan P, Somrit J.
europepmc   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Fibulin 2 Deficiency Drives Epigenetic Hypertension. [PDF]

Hypertension
Han X, Sun Z.
europepmc   +1 more source

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Incidence of Adrenal Masses Eventually Discovered in Patients Screened for Primary Aldosteronism.

J Clin Endocrinol Metab
Kline GA, Low J, Burkart JJ, Hu XY, Mellor K, Przybojewski S, King J, Leung AA.   +7 more
europepmc   +1 more source

Application and accuracy analysis of different facial regions based on deep learning in the diagnosis of hypertension. [PDF]

Sci Rep
Wang J, Zhao M, Zhou H, Liu M, Zhao M, Zhang X.   +5 more
europepmc   +1 more source