Results 281 to 290 of about 2,757,661 (328)

Burden of hypertension and associated risk factors among the Nicobarese tribe of Car Nicobar Island, India

Kannan Thiruvengadam, Nagarajan Muruganandam, Nimisha Sivanandan, Rehnuma Parvez   +3 more
openalex   +2 more sources

The Pivotal Role of GR‐CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo   +9 more
wiley   +1 more source

Cardiac magnetic resonance characteristics and prognostic associations of hypertension-mediated left ventricular hypertrophy. [PDF]

Eur Heart J Imaging Methods Pract
Naderi H, van Duijvenboden S, Ramírez J, Chadalavada S, Rauseo E, Aung N, Petersen SE, Munroe PB.   +7 more
europepmc   +1 more source

A Novel 10‐Protein Score for Liver Fat Content Predicts Cardiovascular‐Kidney‐Metabolic Disease Risk

Advanced Science, EarlyView.
A novel 10‐protein plasma score precisely quantifies liver fat, outperforming the fatty liver index. It robustly predicts the risk of numerous cardiovascular‐kidney‐metabolic diseases and integrates with genetic data for precision prevention, offering a practical alternative to magnetic resonance imaging (MRI). Abstract Liver fat content (LFC) is a key
Xiaoqin Gan, Yuanxiu Wei, Yiting Wu, Xinyue Su, Gangling Wang, Sisi Yang, Ziliang Ye, Yanjun Zhang, Hao Xiang, Yu Huang, Yiwei Zhang, Yuanyuan Zhang, Xianhui Qin   +12 more
wiley   +1 more source

Translating Guidelines, Protocols, and Care Pathways for Hypertension Into Effective Program Implementation. [PDF]

Am J Hypertens
Ordunez P, Angell SY, DiPette DJ, Brettler J, Campbell NRC, Jaffe MG, Chapman N, Rosende A, Ku GM, Londoño E, Piñeiro DJ, Whelton PK.   +11 more
europepmc   +1 more source

Causal Associations Between the Gut Microbiota and Hypertension‐Related Traits Through Mendelian Randomization: A Cross‐Sectional Cohort Study

Yunfan Tian, Mingxia Gu, Dazhong Chen, Quanbin Dong, Yifeng Wang, Wei Sun, Xiangqing Kong   +6 more
openalex   +1 more source

Pathomics Signature for Prognosis and CA19‐9 Interception in Pancreatic Ductal Adenocarcinoma: A Real‐Life, Multi‐Center Study

Advanced Science, EarlyView.
This study develops a deep learning‐based pathomics model to predict survival outcomes in pancreatic cancer patients. The CrossFormer architecture analyzes routine H&E‐stained tissue slides, identifying key prognostic features including stromal patterns, cellular characteristics, and immune infiltration.
Qiangda Chen, Zhihang Xu, Yiping Zou, Zhenlai Jiang, Yecheng Li, Taochen He, Hanlin Yin, Jiali Li, Yanfei An, Jiande Han, Yuqi Xie, Wei Gan, Yaolin Xu, Wenquan Wang, Junyi He, Haibo Wang, Wenchuan Wu, Zhenyu Ye, Wenhui Lou, Jihui Hao, Liang Liu, Jun Yu, Ning Pu   +22 more
wiley   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Peripartum Telehealth Care Utilization During the COVID-19 Pandemic, by Hypertension Status, PCORnet®, 2018 to 2023. [PDF]

Med Care
Kuklina EV, Lekiachvili A, Rohan A, Womack-Martenson LS, Jackson SL, Clark EA, Block JP, Carton T, Cowell L, Draper C, Rasmussen SA, Smith S, Thacker D, Wiltz JL, PCORnet writing committee coauthors, on behalf of PCORnet Network Partners.   +15 more
europepmc   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source