Results 21 to 30 of about 1,745,719 (302)

Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension [PDF]

, 2011
Background: Endothelin-1 signalling plays an important role in pathogenesis of pulmonary hypertension. Although different endothelin-A receptor antagonists are developed, a novel therapeutic option to cure the disease is still needed.
Norbert Weissmann, Sydykov, Akylbek, Brandes, Ralf, Schermuly, Ralph T., Hossein A Ghofrani, Janssen, Wiebke, Seeger Werner, Ralf P Brandes, Neil Davie, Dahal, Bhola K., Davie, Neil, Janssen Wiebke, Davie Neil, Ghofrani Hossein A, Seeger, Werner, Cornitescu, Teodora, Brandes Ralf P, Cornitescu Teodora, Kosanovic, Djuro, Kojonazarov, Baktybek, Werner Seeger, Friedrich Grimminger, Ghofrani, Hossein Ardeschir, Grimminger, Friedrich, Dahal Bhola K, Djuro Kosanovic, Baktybek Kojonazarov, Teodora Cornitescu, Schermuly Ralph T, Sydykov Akylbek, Wiebke Janssen, Grimminger Friedrich, Akylbek Sydykov, Kojonazarov Baktybek, Weissmann Norbert, Himal Luitel, Luitel Himal, Ralph T Schermuly, Luitel, Himal, Weißmann, Norbert, Bhola K Dahal, Kosanovic Djuro   +41 more
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Hypertensive target organ damage in Ghanaian civil servants with hypertension. [PDF]

, 2009
BACKGROUND: Low levels of detection, treatment and control of hypertension have repeatedly been reported from sub Saharan Africa, potentially increasing the likelihood of target organ damage.
David A Leon, Leon, David A, Smeeth, Liam, Juliet Addo, Smeeth Liam, Addo Juliet, Addo, Juliet, Liam Smeeth, Leon David A.   +8 more
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Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis

Stem Cell Research & Therapy, 2021
Background Atherosclerotic renal artery stenosis (ARAS) is a risk factor for ischemic and hypertensive kidney disease (HKD) for which autologous mesenchymal stem cell (MSC) appears to be a promising therapy.
Busra Isik, Roman Thaler, Busra B. Goksu, Sabena M. Conley, Hayder Al-Khafaji, Arjunmohan Mohan, Mohsen Afarideh, Abdelrhman M. Abumoawad, Xiang Y. Zhu, James D. Krier, Ishran M. Saadiq, Hui Tang, Alfonso Eirin, LaTonya J. Hickson, Andre J. van Wijnen, Stephen C. Textor, Lilach O. Lerman, Sandra M. Herrmann   +17 more
doaj   +1 more source

Multidisciplinary treatment of patients with diabetes and hypertension: experience of a Brazilian center

Diabetology & Metabolic Syndrome, 2018
Background Although multidisciplinary treatment is recommended for type 2 diabetes mellitus and hypertension (HTN), there is a lack of scientific literature supporting the hypothesis of extending this treatment strategy to patients with both diabetes and
Thiago Veiga Jardim, Sayuri Inuzuka, Luan Galvão, Leandra Anália Freitas Negretto, Rogério Orlow de Oliveira, Wanessa Faria Sá, Haroldo Silva de Souza, Andrea Crisitina Sousa, Patricia Silva Carneiro, Weimar Kunz Sebba Barroso, Ana Luiza Lima Sousa, Paulo César Veiga Jardim   +11 more
doaj   +1 more source

Higher plasma renin activity is associated with increased kidney damage risk in patients with hypertension and glucose metabolic disorders

The Journal of Clinical Hypertension, 2022
The impact of renin on kidney remain unclear among hypertensives with glucose metabolic disorders (GMD). We aimed to evaluate the association between plasma renin activity (PRA) and kidney damage in hypertensive patients with GMD.
Mengyue Lin, Mulalibieke Heizhati, Lin Gan, Jing Hong, Ting Wu, Zuhere Xiamili, Ling Tong, Yue Lin, Nanfang Li   +8 more
doaj   +1 more source

Minor Change of Plasma Renin Activity during the Saline Infusion Test Provide an Auxiliary Diagnostic Value for Primary Aldosteronism

International Journal of Endocrinology, 2021
Context. Failure of plasma aldosterone suppression during the saline infusion test (SIT) confirms primary aldosteronism (PA); recommendations for diagnostic strategies are currently controversial in the case of an inconclusive test result with a post-SIT
Munire Adilijiang, Qin Luo, Menghui Wang, Delian Zhang, Xiaoguang Yao, Guoliang Wang, Keming Zhou, Nanfang Li   +7 more
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Joint UK societies' 2014 consensus statement on renal denervation for resistant hypertension. [PDF]

, 2014
Resistant hypertension continues to pose a major challenge to clinicians worldwide and has serious implications for patients who are at increased risk of cardiovascular morbidity and mortality with this diagnosis.
Matson, M, Williams, B, Paton, JF, Kapil, Vikas, Moss, J, Simpson, Iain, Knight, Charles, Poulter, Neil, Poulter, N, Collier, David, de Belder, Mark A, Caulfield, Mark J, Matson, Matthew, Simpson, I, Cleveland, Trevor, Deanfield, John, Lobo, MD, de Belder, MA, Williams, Bryan, Lobo, Melvin D, Moss, Jonathan, Caulfield, MJ, Kapil, V, Knight, C, Paton, Julian F R, Dasgupta, I, Paton, JFR, Deanfield, J, ?, ?, Cleveland, T, Collier, D, Dasgupta, Indranil   +31 more
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Assessment of sublingual microcirculation for the screening of diabetic nephropathy

Diabetology & Metabolic Syndrome, 2022
Objective To investigate the potential of employing sublingual microcirculation as an early noninvasive screening technique for diabetic nephropathy (DN).
Qiang Li, XiaoXiao Liu, Mengxiao Jia, Fang Sun, Yingsha Li, Hexuan Zhang, Xiaoli Liu, Hongbo He, Zhigang Zhao, Zhencheng Yan, Zhiming Zhu   +10 more
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Primary aldosteronism in Klinefelter’s syndrome: two cases

Endocrinology, Diabetes & Metabolism Case Reports, 2019
Primary aldosteronism (PA) is more common than expected. Aberrant adrenal expression of luteinizing hormone (LH) receptor in patients with PA has been reported; however, its physiological role on the development of PA is still unknown.
Yasufumi Seki, Satoshi Morimoto, Naohiro Yoshida, Kanako Bokuda, Nobukazu Sasaki, Midori Yatabe, Junichi Yatabe, Daisuke Watanabe, Satoru Morita, Keisuke Hata, Tomoko Yamamoto, Yoji Nagashima, Atsuhiro Ichihara   +12 more
doaj   +1 more source

Enhanced Mitochondrial Transient Receptor Potential Channel, Canonical Type 3–Mediated Calcium Handling in the Vasculature From Hypertensive Rats

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundMitochondrial Ca2+ homeostasis is fundamental to the regulation of mitochondrial reactive oxygen species (ROS) generation and adenosine triphosphate production.
Bin Wang, Shiqiang Xiong, Shaoyang Lin, Weijie Xia, Qiang Li, Zhigang Zhao, Xing Wei, Zongshi Lu, Xiao Wei, Peng Gao, Daoyan Liu, Zhiming Zhu   +11 more
doaj   +1 more source