Results 41 to 50 of about 1,745,719 (302)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

The use of statins are associated with an increased risk of new-onset diabetes in patients with hypertension and obstructive sleep apnoea, a longitudinal study

Diabetology & Metabolic Syndrome
Background Statins, a kind of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, are first-line cholesterol-lowering drugs that are widely used in the primary and secondary prevention of coronary atherosclerotic heart disease (CAD ...
Hui Wang, Mulalibieke Heizhati, Nanfang Li, Lin Gan, Ling Yao, Mei Li, Li Cai, Xiufang Li, Xiayire Aierken, Dan Yu, Miaomiao Liu, Adalaiti Maitituersun, Qiaolifanayi Nuermaimaiti, Aketilieke Nusufujiang, Jing Hong   +14 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Screening and management of hypertensive patients with chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. A pilot survey based on questionnaire.

Real-life management of hypertensive patients with chronic kidney disease (CKD) is unclear. A survey was conducted in 2023 by the European Society of Hypertension (ESH) to assess management of CKD patients referred to ESH-Hypertension Excellence Centres (
Mayer, G., Dusing, R., Limbourg, F.P., Saeed, S., Rump, L.C., Kreutz, R., Ruilope, L.M., Águila, F.J., Triantafyllidi, H., Robles, N.R., Tabbalat, R., Polónia, J., Solbu, M., Venzin, R.M., Wuerzner, G., Paixão-Dias, V., Bilo, G., van der Giet, M., Van der Niepen, P., Izzo, R., Zelveian, P., Viigimaa, M., Nasr, E., Mourad, J.J., Kahan, T., Persu, A., Chapman, N., Ormezzano, O., Widimsky, J., Papadakis, I., Kantola, I., Deinum, J., Guerrot, D., Gordin, D., MacIntyre, I.M., Silhol, F., Rubin, S., Camafort, M., Lopez-Sublet, M., Sokolovic, S., Papadopoulos, D., Tsioufis, K., Bursztyn, M., Lueders, S., Tengiz, I., Weber, T., Mallamaci, F., Huart, J., Marketou, M., Muiesan, M.L., Gaciong, Z., Burkard, T., Oliveras, A., Grassos, C., Nilsson, P., Fauvel, J.P., Sanidas, E., Stergiou, G., Mazza, A., Václavík, J., Schmieder, R., Sudano, I., Duly-Bouhanick, B., Sarafidis, P., Manolis, A., Delmotte, P., Pucci, G., Grassi, G., Cottone, S., Pontremoli, R., Doumas, M., Soucek, M., Fesler, P., Sarzani, R., Kociánová, E., Zebekakis, P., Vogt, L., Dorobantu, M., Járai, Z., Veglio, F., de Backer, T., Perl, S., Azizi, M., Gkaliagkousi, E., Halimi, J.M.   +84 more
core   +2 more sources

Changes in the prevalence, treatment and control of hypertension in Germany? : a clinical-epidemiological study of 50.000 primary care patients [PDF]

, 2012
INTRODUCTION: Medical societies have developed guidelines for the detection, treatment and control of hypertension (HTN). Our analysis assessed the extent to which such guidelines were implemented in Germany in 2003 and 2001. METHODS: Using standardized
L. Pieper (7659041), März Winfried, Alexander Michael Labeit, Pittrow David, Einsle Franziska, Lehnert Hendrik, Pittrow, D., Pittrow, David, Franziska Einsle, Hendrik Lehnert, März, Winfried, Sigmund Silber, Wehling Martin, Wittchen Hans-Ulrich, Günter Karl Stalla, Einsle, F., Klotsche, J., H. U. Wittchen (7659065), Klotsche, Jens, Wehling, Martin, A. M. Labeit (7659035), Klotsche Jens, A. M. Zeiher (7659059), Zeiher, A.M., Zeiher, Andreas M., Winfried März, Einsle, Franziska, Wittchen, H.U., Lehnert, Hendrik, Lehnert, H., W. März (7609394), Wehling, M., G. K. Stalla (7659050), Silber, Sigmund, Zeiher Andreas Michael, M. Wehling (7659062), Pieper, L., Jens Klotsche, David Pittrow, Labeit Alexander Michael, Hans-Ulrich Wittchen, Stalla, Günter K., Lars Pieper, Labeit, A.M., Martin Wehling, Silber Sigmund, H. Lehnert (7659053), Labeit, Alexander Michael, Pieper, Lars, März, W., F. Einsle (7659047), Andreas Michael Zeiher, J. Klotsche (7659038), Wittchen, Hans-Ulrich, Pieper Lars, Stalla Günter Karl, D. Pittrow (7659044), S. Silber (7659056), Stalla, G.K., Silber, S.   +59 more
core   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Current Pharmacological Treatment Of Hypertension

, 2023
Hypertension accounts for one of the chronic diseases that increases the morbidity, mortality and reduces the quality of life mostly in the aging population. Early intervention is key to reduce the growing worldwide epidemic of hypertension and end organ
Chinedu, Wendy Ifunanya
core