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Subclinical primary aldosteronism [PDF]

Archives of Endocrinology and Metabolism
Primary aldosteronism (PA) is a major contributor to hypertension and cardiovascular disease. Subclinical PA, a preclinical or early manifestation of PA, has been identified in individuals with normal blood pressure and in those with mild hypertension ...
Stéfanie Parisien-La Salle, Jenifer M. Brown, Cheng Hsuan Tsai, Gregory L. Hundemer, Anand Vaidya   +4 more
doaj   +5 more sources

Secondary Adrenal Insufficiency Presenting With Severe Hyponatremia in an Elderly Patient With Primary Aldosteronism Suggesting Underlying Autonomous Cortisol Secretion

Clinical Case Reports
Possible unrecognized cortisol autonomy in primary aldosteronism may suppress the hypothalamic–pituitary–adrenal axis. Under physiological stress, this may contribute to secondary adrenal insufficiency and severe hyponatremia.
Minami Toda, Shunsuke Takahashi, Hitomi Saito, Honami Mori, Yutaka Kuroda, Akito Maeshima   +5 more
doaj   +2 more sources

Mutation in Aldosterone Producing Adenoma [PDF]

Endocrinology and Metabolism, 2017
Discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas (APAs) with distinct clinical presentations and pathological features. Catenin β1 (CTNNB1) mutation in APAs has been recently described and discussed in
Jian-Jhong Wang, Kang-Yung Peng, Vin-Cent Wu, Fen-Yu Tseng, Kwan-Dun Wu   +4 more
doaj   +1 more source

Markers of Kidney Tubular Function Deteriorate While Those of Kidney Tubule Health Improve in Primary Aldosteronism After Targeted Treatments

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Targeted treatment with mineralocorticoid receptor antagonists (MRAs) or adrenalectomy in patients with primary aldosteronism (PA) causes a decline in estimated glomerular filtration rate; however, the associated simultaneous changes in ...
Vin‐Cent Wu, Chieh‐Kai Chan, Jeff S. Chueh, Yung‐Ming Chen, Yen‐Hung Lin, Chin‐Chen Chang, Po‐Chih Lin, Shiu‐Dong Chung   +7 more
doaj   +1 more source

Benefits of Surgical Over Medical Treatment for Unilateral Primary Aldosteronism

Frontiers in Endocrinology, 2022
Primary aldosteronism is the most common and modifiable form of secondary hypertension. Left untreated, primary aldosteronism leads high rates of cardiovascular, metabolic, and kidney disease.
Sumaiya Ahmed, Gregory L. Hundemer
doaj   +1 more source

PRIMARY ALDOSTERONISM: CURRENT DIAGNOSTIC APPROACH

Байкальский медицинский журнал, 2022
Primary aldosteronism is characterized by aldosterone secretion that is independent of renin and angiotensin II. The deleterious effects of primary aldosteronism are mediated by excessive activation of the mineralocorticoid receptor that results in the ...
Elena S. Eniseeva
doaj   +1 more source

Cortisol Co-Secretion and Clinical Usefulness of ACTH Stimulation Test in Primary Aldosteronism: A Systematic Review and Biases in Epidemiological Studies

Frontiers in Endocrinology, 2021
The hypothalamus-pituitary-adrenal (HPA) axis plays an important role in primary aldosteronism. Aldosterone biosynthesis is regulated not only by angiotensin II in the renin-angiotensin-aldosterone system, but also by adrenocorticotropic hormone (ACTH ...
Kosuke Inoue, Kosuke Inoue, Takumi Kitamoto, Takumi Kitamoto, Yuya Tsurutani, Jun Saito, Masao Omura, Tetsuo Nishikawa   +7 more
doaj   +1 more source

Primary aldosteronism

Gland Surgery, 2020
Primary aldosteronism (PA) is a common cause of secondary hypertension caused by excessive and inappropriate secretion of the hormone aldosterone from one or both adrenal glands. The prevalence of PA ranges from 10% in the general hypertensive population to 20% in resistant hypertension, yet only a small fraction of patients is diagnosed.
Sean M, Wrenn, Anand, Vaidya, Carrie C, Lubitz   +2 more
openaire   +2 more sources

Concurrence of overt Cushing’s syndrome and primary aldosteronism accompanied by aldosterone-producing cell cluster in adjacent adrenal cortex: case report

BMC Endocrine Disorders, 2021
Background Various adrenal disorders including primary aldosteronism and Cushing’s syndrome lead to the cause of hypertension. Although primary aldosteronism is sometimes complicated with preclinical Cushing’s syndrome, concurrence of overt Cushing’s ...
Yoshiro Fushimi, Fuminori Tatsumi, Junpei Sanada, Masashi Shimoda, Shinji Kamei, Shuhei Nakanishi, Kohei Kaku, Tomoatsu Mune, Hideaki Kaneto   +8 more
doaj   +1 more source

Consensus on Clinical Application of the CXCR4-targeted Imaging in the Diagnosis of Primary Aldosteronism(2022)

Xiehe Yixue Zazhi, 2022
Subtype classification of primary aldosteronism is important but challenging. Increasing evidence has shown that 68Ga-Pentixafor PET/CT imaging which targets CXCR4 is beneficial to the subtype classification of primary aldosteronism.
Chinese Urological Doctor Association Adrenal Hypertension Surgery Collaborative Organization Adrenal Group, Chinese Society of Endocrinology PET group, Chinese Society of Nuclear Medicine   +2 more
doaj   +1 more source