Results 21 to 30 of about 4,291,747 (219)

Mutation in Aldosterone Producing Adenoma [PDF]

Endocrinology and Metabolism, 2017
Discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas (APAs) with distinct clinical presentations and pathological features. Catenin β1 (CTNNB1) mutation in APAs has been recently described and discussed in
Jian-Jhong Wang, Kang-Yung Peng, Vin-Cent Wu, Fen-Yu Tseng, Kwan-Dun Wu   +4 more
doaj   +1 more source

Markers of Kidney Tubular Function Deteriorate While Those of Kidney Tubule Health Improve in Primary Aldosteronism After Targeted Treatments

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Targeted treatment with mineralocorticoid receptor antagonists (MRAs) or adrenalectomy in patients with primary aldosteronism (PA) causes a decline in estimated glomerular filtration rate; however, the associated simultaneous changes in ...
Vin‐Cent Wu, Chieh‐Kai Chan, Jeff S. Chueh, Yung‐Ming Chen, Yen‐Hung Lin, Chin‐Chen Chang, Po‐Chih Lin, Shiu‐Dong Chung   +7 more
doaj   +1 more source

Single-Center Prospective Cohort Study on the Histopathology, Genotype, and Postsurgical Outcomes of Patients With Primary Aldosteronism [PDF]

, 2021
Unilateral forms of primary aldosteronism are usually surgically treated to remove the source of aldosterone excess. After adrenalectomy, aldosteronism persists in some patients indicating abnormal aldosterone production from the unresected gland.
Bidlingmaier, Martin, Udager, Aaron, Meyer, Lucie S., Handgriff, Laura, Wildgruber, Moritz, Lim, Jung Soo, Ladurner, Roland, Williams, Tracy Ann, Kinker, Isabella-Sabrina, Knösel, Thomas, Rainey, William E., Reincke, Martin   +11 more
core   +1 more source

Benefits of Surgical Over Medical Treatment for Unilateral Primary Aldosteronism

Frontiers in Endocrinology, 2022
Primary aldosteronism is the most common and modifiable form of secondary hypertension. Left untreated, primary aldosteronism leads high rates of cardiovascular, metabolic, and kidney disease.
Sumaiya Ahmed, Gregory L. Hundemer
doaj   +1 more source

Angiotensin II Type 1 Receptor Autoantibodies in Primary Aldosteronism [PDF]

, 2020
Primary aldosteronism (PA) is the most common form of endocrine hypertension. Agonistic autoantibodies against the angiotensin II type 1 receptor (AT1R-Abs) have been described in transplantation medicine and women with pre-eclampsia and more recently in
Siyuan, Gong, Meyer, Lucie, Williams, Tracy Ann, Reincke, Martin   +3 more
core   +1 more source

Cortisol Co-Secretion and Clinical Usefulness of ACTH Stimulation Test in Primary Aldosteronism: A Systematic Review and Biases in Epidemiological Studies

Frontiers in Endocrinology, 2021
The hypothalamus-pituitary-adrenal (HPA) axis plays an important role in primary aldosteronism. Aldosterone biosynthesis is regulated not only by angiotensin II in the renin-angiotensin-aldosterone system, but also by adrenocorticotropic hormone (ACTH ...
Kosuke Inoue, Kosuke Inoue, Takumi Kitamoto, Takumi Kitamoto, Yuya Tsurutani, Jun Saito, Masao Omura, Tetsuo Nishikawa   +7 more
doaj   +1 more source

Concurrence of overt Cushing’s syndrome and primary aldosteronism accompanied by aldosterone-producing cell cluster in adjacent adrenal cortex: case report

BMC Endocrine Disorders, 2021
Background Various adrenal disorders including primary aldosteronism and Cushing’s syndrome lead to the cause of hypertension. Although primary aldosteronism is sometimes complicated with preclinical Cushing’s syndrome, concurrence of overt Cushing’s ...
Yoshiro Fushimi, Fuminori Tatsumi, Junpei Sanada, Masashi Shimoda, Shinji Kamei, Shuhei Nakanishi, Kohei Kaku, Tomoatsu Mune, Hideaki Kaneto   +8 more
doaj   +1 more source

Salt Appetite and its Effects on Cardiovascular Risk in Primary Aldosteronism [PDF]

, 2020
First described in 1955 by Jerome W. Conn, primary aldosteronism (PA) today is well established as a relevant cause of secondary hypertension and accounts for about 5–10 % of hypertensives.
Heinrich, Daniel A., Schneider, Holger, Handgriff, Laura, Adolf, Christian, Reincke, Martin   +4 more
core   +1 more source

Primary Aldosteronism and Cardiovascular Events: It is time to take guideline recommendations seriously [PDF]

, 2018
It is nowadays widely accepted that primary aldosteronism is the most frequent cause of endocrine hypertension. Prevalence rates among patients with hypertension are 6% in the primary care setting and 11% in tertiary care referral centers (1).
Martin Reincke, Reincke, Martin
core   +1 more source

Consensus on Clinical Application of the CXCR4-targeted Imaging in the Diagnosis of Primary Aldosteronism(2022)

Xiehe Yixue Zazhi, 2022
Subtype classification of primary aldosteronism is important but challenging. Increasing evidence has shown that 68Ga-Pentixafor PET/CT imaging which targets CXCR4 is beneficial to the subtype classification of primary aldosteronism.
Chinese Urological Doctor Association Adrenal Hypertension Surgery Collaborative Organization Adrenal Group, Chinese Society of Endocrinology PET group, Chinese Society of Nuclear Medicine   +2 more
doaj   +1 more source